2007
DOI: 10.1016/j.jpedsurg.2006.12.048
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Esophageal smooth muscle reactivity is impaired in chronic reflux esophagitis by both receptor- and nonreceptor-mediated mechanisms

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Cited by 12 publications
(10 citation statements)
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“…In other words, there were heightened immune responses within the duodenal mucosa in animals with SIBO. Recently, impaired esophageal smooth muscle reactivity was documented in a chronic reflux esophagitis rat model [28]. A mild chronic inflammatory state or immune response by SIBO might therefore maintain smooth muscle dysfunction in both the upper and lower gut in some predisposed individuals expressed as GERD and IBS symptoms.…”
Section: Discussionmentioning
confidence: 99%
“…In other words, there were heightened immune responses within the duodenal mucosa in animals with SIBO. Recently, impaired esophageal smooth muscle reactivity was documented in a chronic reflux esophagitis rat model [28]. A mild chronic inflammatory state or immune response by SIBO might therefore maintain smooth muscle dysfunction in both the upper and lower gut in some predisposed individuals expressed as GERD and IBS symptoms.…”
Section: Discussionmentioning
confidence: 99%
“…It was reported that neurotransmitters regulating gastrointestinal motility, secretion, and sensation play an important role in the RE pathogenesis. Rats with esophageal reflux have decreased smooth muscle contractile responses to carbachol (receptor mediated) and KCl (non-receptor mediated), as well as decreased relaxation to 5-HT (receptor mediated) [9]. …”
Section: Discussionmentioning
confidence: 99%
“…The inflammatory factors affect esophageal motility through multiple ways. Except for inducing chemotaxis of leukocyte, they also directly impair the SMCs contractility 12,13. In addition, the inflammation factors also mediate the interaction between SMC and myenteric plexus neurons in esophagus by inducing glial cell line-derived neurotrophic factor (GDNF) and nerve growth factor (NGF) expression in SMCs 14.…”
Section: Introductionmentioning
confidence: 99%