Erosive esophagitis may be related to small intestinal bacterial overgrowth

Kim, Kwangmin; Kim, Bom-Taeck; Lee, Duck-Joo; Park, Sat-Byul; Joo, Nam-Seok; Kim, Young-Sang; Kim, Kyunam

doi:10.3109/00365521.2012.668932

Cited by 11 publications

(7 citation statements)

References 34 publications

(31 reference statements)

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“…In addition, some authors observed a higher frequency of bacterial overgrowth of the small intestine in patients with esophagitis (25) . Other study observed that the colonic fermentation of non-digestible carbohydrates by intestinal microbiota caused a higher rate of transient relaxation of the LES, a larger number of episodes of acid reflux, and symptoms of GERD (17) .…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Intestinal Microbiota in Adults With Erosive Esophagitis

Baima

Carvalho

Navarro–Rodriguez

2021

Arq. Gastroenterol.

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BACKGROUND: The intestinal microbiota influences the appropriate function of the gastrointestinal tract. Intestinal dysbiosis may be associated with a higher risk of esophageal lesions, mainly due to changes in gastroesophageal motility patterns, elevation of intra-abdominal pressure, and increased frequency of transient relaxation of the lower esophageal sphincter. OBJECTIVE: The aim of this study was to evaluate the intestinal microbiota in individuals with erosive esophagitis and in healthy individuals using metagenomics. METHODS: A total of 22 fecal samples from adults aged between 18 and 60 years were included. Eleven individuals had esophagitis (eight men and three women) and 11 were healthy controls (10 men and one woman). The individuals were instructed to collect and store fecal material into a tube containing guanidine solution. The DNA of the microbiota was extracted from each fecal samples and PCR amplification was performed using primers for the V4 region of the 16S rRNA gene. The amplicons were sequenced using the Ion Torrent PGM platform and the data were analyzed using the QIIME™ software version 1.8. Statistical analyses were performed using the Mann-Whitney non-parametric test and the ANOSIM non-parametric method based on distance matrix. RESULTS: The alpha-diversity and beta-diversity indices were similar between the two groups, without statistically significant differences. There was no statistically significant difference in the phylum level. However, a statistically significant difference was observed in the abundance of the family Clostridiaceae (0.3% vs 2.0%, P=0.032) and in the genus Faecaliumbacterium (10.5% vs 4.5%, P=0.045) between healthy controls and esophagitis patients. CONCLUSION: The findings suggest that reduced abundance of the genus Faecaliumbacterium and greater abundance of the family Clostridiaceae may be risk factors for the development of erosive esophagitis. Intervention in the composition of the intestinal microbiota should be considered as an adjunct to current therapeutic strategies for this clinical condition.

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Section: Discussionmentioning

confidence: 99%

Assessment of the Intestinal Microbiota in Adults With Erosive Esophagitis

Baima

Carvalho

Navarro–Rodriguez

2021

Arq. Gastroenterol.

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“…A study by Kim et al demonstrated that SIBO is more prevalent in patients with GERD (assessed with the LBT) than in the general population [47].…”

Section: Association Between Sibo and Other Nosological Entitiesmentioning

confidence: 99%

Current views on the etiopathogenesis, clinical manifestation, diagnostics, treatment and correlation with other nosological entities of SIBO

Miazga

Osiński

Cichy

et al. 2015

Advances in Medical Sciences

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“…Patients with erosive esophagitis had SIBO more frequently than controls (65% vs 31%; OR = 4.0)[ 99 ].…”

Section: Other Digestive Diseasesmentioning

confidence: 99%

Epidemiology of small intestinal bacterial overgrowth

Efremova,

Maslennikov,

Poluektova

et al. 2023

World J Gastroenterol

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Small intestinal bacterial overgrowth (SIBO) is defined as an increase in the bacterial content of the small intestine above normal values. The presence of SIBO is detected in 33.8% of patients with gastroenterological complaints who underwent a breath test, and is significantly associated with smoking, bloating, abdominal pain, and anemia. Proton pump inhibitor therapy is a significant risk factor for SIBO. The risk of SIBO increases with age and does not depend on gender or race. SIBO complicates the course of a number of diseases and may be of pathogenetic significance in the development of their symptoms. SIBO is significantly associated with functional dyspepsia, irritable bowel syndrome, functional abdominal bloating, functional constipation, functional diarrhea, short bowel syndrome, chronic intestinal pseudo-obstruction, lactase deficiency, diverticular and celiac diseases, ulcerative colitis, Crohn’s disease, cirrhosis, metabolic-associated fatty liver disease (MAFLD), primary biliary cholangitis, gastroparesis, pancreatitis, cystic fibrosis, gallstone disease, diabetes, hypothyroidism, hyperlipidemia, acromegaly, multiple sclerosis, autism, Parkinson’s disease, systemic sclerosis, spondylarthropathy, fibromyalgia, asthma, heart failure, and other diseases. The development of SIBO is often associated with a slowdown in orocecal transit time that decreases the normal clearance of bacteria from the small intestine. The slowdown of this transit may be due to motor dysfunction of the intestine in diseases of the gut, autonomic diabetic polyneuropathy, and portal hypertension, or a decrease in the motor-stimulating influence of thyroid hormones. In a number of diseases, including cirrhosis, MAFLD, diabetes, and pancreatitis, an association was found between disease severity and the presence of SIBO. Further work on the effect of SIBO eradication on the condition and prognosis of patients with various diseases is required.

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Erosive esophagitis may be related to small intestinal bacterial overgrowth

Abstract: Subjects with EE had a higher prevalence of SIBO, as assessed by the lactulose hydrogen breath test, with respect to a control group. These findings may suggest that EE is associated with SIBO.

Cited by 11 publications

References 34 publications

Assessment of the Intestinal Microbiota in Adults With Erosive Esophagitis

Assessment of the Intestinal Microbiota in Adults With Erosive Esophagitis

Current views on the etiopathogenesis, clinical manifestation, diagnostics, treatment and correlation with other nosological entities of SIBO

Epidemiology of small intestinal bacterial overgrowth

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