Esophageal cancer: Recent advances in screening, targeted therapy, and management

Gaur, Puja; Kim, Min P.; Dunkin, Brian J.

doi:10.4103/1477-3163.143720

Cited by 33 publications

(36 citation statements)

References 43 publications

(47 reference statements)

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“…Some of the causes include intake of excessive alcohol, consumption of hot beverages and red meat (Rubenstein and Chen, 2014). The absence of characteristic clinical symptoms in the early stage hinders the detection and treatment (Gaur et al, 2014). Therefore, in most of the cases squamous cell carcinoma is detected at metastasis stage making the treatment difficult.…”

Section: Introductionmentioning

confidence: 99%

Casticin treatment inhibits squamous cell carcinoma cell proliferation and arrests cell cycle in S phase

Song

Zhou

Cui

et al. 2016

Bangladesh J Pharmacol

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The present study demonstrates the effect of casticin on esophageal squamous cell carcinoma cell lines, TE-1 and TE-15. The cells were treated with various concentrations (10-50 μM) of casticin for different time periods. The results revealed that casticin treatment significantly inhibited the rate of cell proliferation in both TE-1 and TE-15 cell lines after 48 hours. Casticin treatment induced cell cycle arrest in S phase, enhanced the expression of proapoptotic gene, Bax and activation of caspase-3. Moreover, the morphological features of the cells were altered resulting in apoptosis. Casticin also inhibited the migration potential of TE-1 cells. Thus, casticin exhibits inhibitory effect on the esophageal squamous cell carcinoma cell lines by inhibiting cell proliferation, arresting cell cycle, inducing apoptosis and inhibiting migration. Therefore, casticin can be of therapeutic importance for the treatment of esophageal squamous cell carcinoma. Article Info

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Section: Introductionmentioning

confidence: 99%

Casticin treatment inhibits squamous cell carcinoma cell proliferation and arrests cell cycle in S phase

Song

Zhou

Cui

et al. 2016

Bangladesh J Pharmacol

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“…(2) Although the dosing accuracy of instantaneous blood concentration is high, it cannot long enough to maintain the effective blood drug concentration [15,49]. …”

Section: Arterial Infusionmentioning

confidence: 99%

“…Interventional treatment, including endoscopic resection (ER), stent placement, arterial infusion, photodynamic therapy (PDT), radiofrequency ablation (RFA) and so on, is among the most important methods in the treatment of EC, with excellent effect and reliable with little harm [15]. This review will provide an overview of interventional treatment in EC, with emphasis on the indications, methods, complications, and clinical outcomes of these methods.…”

Section: Introductionmentioning

confidence: 99%

Interventional Therapy of Esophageal Cancer

Mao

2016

Gastrointest Tumors

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Esophageal cancer (EC) is the fourth leading cause of cancer death in China. Despite a lot of advances in diagnosis and therapy, the survival rate of patients with EC is low. There is urgent need for a variety of methods and techniques to improve the survival time and alleviate the lesions of EC. Nowadays, alternative and less invasive approaches to the treatment of ECs are being identified. Here, we review several main interventional methods at different stages of EC, including endoscopic resection, stent placement, arterial infusion, photodynamic therapy, and radiofrequency ablation. This review will focus on the indications, methods, clinical outcomes, and complications of these methods, which may help guide the way forward.

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“…The majority of esophageal cancer patients hospitalized are often diagnosed with advanced ESCC that metastasizes to local lymph nodes (3,4). Thus, the outcomes and prognosis of patients with ESCC are poor (5), despite the improvements in therapy (6), with the 5-year survival rate being no more than 15% (7). Therefore, it is necessary to understand the mechanism of lymph node metastasis of ESCC (8).…”

Section: Introductionmentioning

confidence: 99%

KIAA1377 is associated with lymph node metastasis in esophageal squamous cell carcinoma

Yang

Liu

et al. 2016

Oncology Letters

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Abstract. KIAA1377, of which there are few studies regarding cell biology and neurological diseases, has been found to be significantly amplified in esophageal squamous cell carcinoma (ESCC) with lymph node metastasis compared with ESCC without lymph node metastasis. This suggests that KIAA1377 may play a role in the lymph node metastasis of ESCC. There has, to the best of our knowledge, been no study performed to investigate the role of KIAA1377 in ESCC. In the present study, the expression of KIAA1377 was detected by immunohistochemistry, and its expression was statistically analyzed with clinicopathological parameters, using commercially obtained tissue arrays consisting of 86 cases of ESCC and 79 paired controls. KIAA1377 was knocked down ex vivo using transient transfection with specific small hairpin RNA (shRNA) vectors into ESCC TE-1 and EC9706 cell lines whose endogenous KIAA1377 level was highest. The variation of proliferation, migration and invasion were evaluated using methyl thiazolyl tetrazolium, wound healing and Transwell assay, respectively. It was found in vivo that KIAA1377 expression was significantly associated with lymph node metastasis and differentiation, and ex vivo that knockdown of KIAA1377 cannot significantly affect proliferation and mobility in the ESCC cell line TE-1. Overall, this is the first study suggesting that KIAA1377 may play a role in the lymph node micrometastasis of ESCC.

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Esophageal cancer: Recent advances in screening, targeted therapy, and management

Cited by 33 publications

References 43 publications

Casticin treatment inhibits squamous cell carcinoma cell proliferation and arrests cell cycle in S phase

Casticin treatment inhibits squamous cell carcinoma cell proliferation and arrests cell cycle in S phase

Interventional Therapy of Esophageal Cancer

KIAA1377 is associated with lymph node metastasis in esophageal squamous cell carcinoma

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