Interventional Therapy of Esophageal Cancer

Mao, Aiwu

doi:10.1159/000447512

Cited by 11 publications

(9 citation statements)

References 53 publications

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“…SEMS placement is used widely for the palliative treatment of unresectable malignant esophageal stricture [ 1 – 3 ]. Major complications such as hemorrhaging, perforation, fistula, a fever, and aspiration pneumonia occurred in 22% of subjects [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Efficacy of Self-Expandable Metallic Stent Placement in the Unresectable Esophageal Cancer Patients

Uesato

Akutsu

Murakami

et al. 2017

Gastroenterology Research and Practice

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This is a retrospective study to evaluate the prevention of complications of metallic stent placement in patients with unresectable advanced esophageal cancer. A total of 87 patients were treated with 4 types of metal stents in the esophagus over a period of 18 years. Stent placement was technically successful. The most common prior treatment was chemoradiotherapy. There were no significant differences in the rate of patients with no complications among the prior treatments. Approximately, 30% of patients had the most common chest pain in complications. Stent placement within one month after the completion of chemoradiotherapy should be avoided for the prevention of the chest pain. There was no significant difference in the rate of patients with no complications by lesion location. The rate of no complications was higher for the Niti-S stent than the Gianturco Z-stent or Ultraflex stent. Of note, no complications were noted for the Niti-S ultrathin stent at all. Among cases of stent-related death, the most common type of complication was respiratory disorder caused by the stent that seems to be thick and hard. Therefore, the stent with thin and flexible characteristics like the Niti-S ultrathin stent will solve the various problems of esophageal stent placement.

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Section: Discussionmentioning

confidence: 99%

Comparison of Efficacy of Self-Expandable Metallic Stent Placement in the Unresectable Esophageal Cancer Patients

Uesato

Akutsu

Murakami

et al. 2017

Gastroenterology Research and Practice

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“…Stent selection should be basis on tumor location, operator experience and expected survival [10,15,17]. Stent placement sometimes requires both endoscopic and fluoroscopic guidance [22]. The SEMS should be placed 2cm above and below the neoplastic lesion and dilatation is not necessary.…”

Section: Technique Of Insertionmentioning

confidence: 99%

“…Tumor ingrowth can be decreased by using of covered SEMS, but with an increased rate of stent migration [10,15]. The migration risk increase when the stent is placed across the gastroesophageal junction [22]. Partially covered SEMS help to prevent migration but their removal is sometimes difficult according to high rate of tumor in growth [18,31].…”

Section: Post Procedures Complicationsmentioning

confidence: 99%

Palliation of Neoplastic Esophageal Strictures with Metallic Stents

Nozari¹

2017

JCTR

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Abstract:Most patients with advanced esophageal neoplasm have dysphagia and suffer from cachexia and malnourishment.Supportive treatments focus on symptom palliation and improving quality of life at this time. Guidelines illustrated some indications for stent use in esophageal neoplasm such as inoperable neoplastic obstruction, presence of neoplastic fistula or perforation, tumor recurrence and contraindication for chemo-radiotherapy. Palliative stents help relieve dysphagia, manage mouth secretions, reduce aspiration risk, and maintain oral intake. Stent placement sometimes requires both endoscopic and fluoroscopic guidance. A stricture dilation is not necessary before stent placement. Success rate of SEMS placement was reported 80-100%. Complications of stents are bleeding, perforation, migration, and tumor ingrowth. Coated SEMS are the treatment of choice in the presence of neoplastic trachea-esophageal fistula. Partially covered stents are used for neoplastic stricture but their removal is sometimes difficult. The stent can be left in esophagus indefinitely for palliation in cases with progressive disease. In this article, we reviewed the recent literatures for efficacy of palliative metal stents placement in patients with esophageal neoplasm.

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“…Esophageal squamous cell carcinoma (ESCC) is a common tumor of the digestive tract. The incidence and mortality of ESCC varies among countries, and China has a high ESCC risk (1,2). Thanks to the development of genetic and molecular biology, pathogenesis of ESCC is now better understood.…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that dysregulated miRs might have a role in of tumors development (8). Notably, miR-490-3p has been reported to be associated with the incidence of various types of cancer (1,(9)(10)(11)(12)(13)(14)(15)(16). In the present study, analysis of miRs expression in ESCC tissues and adjacent tissues from The Cancer Genome Atlas (TCGA) database demonstrated that miR-490-3p was significantly lower in ESCC tissues; however, the role of miR-490-3p in ESCC remains unknown.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑490‑3p inhibits proliferation and stimulates apoptosis of ESCC cells via MAPK1 downregulation

et al. 2019

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The present study aimed to investigate whether microRNA (miR)-490-3p can regulate MAPK1 expression, increase proliferation of esophageal squamous cell carcinoma (ESCC) and reduce ESCC cell apoptosis. The Cancer Genome Atlas (TCGA) database was used to explore the functional role of miR-490-3p in ESCC. The expression of miR-490-3p in ESCC tissues and adjacent tissues of patients with ESCC were detected by reverse transcription-quantitative PCR. The effect of miR-490-3p on ESCC cell proliferation and apoptosis were detected by cell counting kit-8 and clone formation assay, and flow cytometry, respectively. The dual luciferase reporter assay was used for detect the regulatory association between miR-490-3p and MAPK1. The TCGA dataset demonstrated that miR-490-3p expression was reduced in ESCC tissues compared with normal tissue. The expression of miR-490-3p was also lower in ESCC tissues compared with adjacent tissues. The expression of miR-490-3p in patients with stage III and IV ESCC were significantly lower than those in stage I and II. In patients with tumor >3 cm, miR-490-3p expression was lower than in patients with tumor <3 cm. Gene set enrichment analysis demonstrated that miR-490-3p may essentially regulate cell apoptosis. In addition, miR-490-3p depletion in TE1 and ECA109 cell lines promoted cell proliferation and inhibited cell apoptosis. The results from dual luciferase reporter assay demonstrated that miR-490-3p may be able to degrade MAPK1. Furthermore, MAPK1 overexpression in TE1 and ECA109 cells partially reversed the effects of miR-490-3p on cell proliferation and apoptosis. Low expression of miR-490-3p may therefore promote the proliferation and inhibit the apoptosis of ESCC cells by regulating MAPK1.

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Interventional Therapy of Esophageal Cancer

Cited by 11 publications

References 53 publications

Comparison of Efficacy of Self-Expandable Metallic Stent Placement in the Unresectable Esophageal Cancer Patients

Comparison of Efficacy of Self-Expandable Metallic Stent Placement in the Unresectable Esophageal Cancer Patients

Palliation of Neoplastic Esophageal Strictures with Metallic Stents

MicroRNA‑490‑3p inhibits proliferation and stimulates apoptosis of ESCC cells via MAPK1 downregulation

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