Esomeprazole

Abstract

Esomeprazole is an effective, well tolerated treatment for managing GORD and for eradicating H. pylori infection in patients with duodenal ulcer disease. In 8-week double-blind trials, esomeprazole healed oesophagitis and resolved symptoms in patients with endoscopically confirmed erosive oesophagitis and overall, provided better efficacy than omeprazole. Notably, in a large (n >5000 patients) double-blind trial, esomeprazole 40mg provided significantly better efficacy than lansoprazole in terms of healing rates and resolution of symptoms. Long-term therapy with esomeprazole maintained healed oesophagitis in these patients. Esomeprazole also proved beneficial in patients with symptomatic GORD without oesophagitis. Thus, esomeprazole has emerged as an option for first-line therapy in the management of acid-related disorders.

Gastritis and Peptic Ulcer Diseases in Dogs: A Review

“…Ranitidine @2mg/kg IV q 12 hr has not been shown a major effect on gastric acid suppression . Proton pump inhibitors are the most potent agents for suppression of gastric acid secretion by the inhibition of the gastric H+/K+-ATPase enzyme (the proton pump), which leads to failing the gastric secretion and rising the intragastric mucosal pH (Miner et al, 2003;Scott et al, 2002). Mainly clinically available proton pump inhibitors (PPI) are omeprazole, esomeprazole, lansoprazole, rabeprazole, and pantoprazole (Miner et al, 2003).…”

Recent Advances in Biomimetic Synthesis Involving Cyclodextrins

“…Benzimidazole is a potential heterocyclic pharmacophore responsible for a number of important pharmacological properties, such as anti-pyretic, antihistaminic, anti-allergic (Nakano et al, 2000), and anti-ulcerative (Scott et al, 2002). They are also effective against various viruses like influenza, human cyto-megalovirus, and HIV.…”

Crystal and Molecular Structure of 2-(2-Fluoro-phenyl)-1H-benzoimidazole

“…Not only can they be used for producing medicines such as omeprazole and pimobendan, but also have they exhibited significant activities against some viruses including RSV 2 , herpes (HCV) 3 , HIV 4 and human cytomegalovirus (HCMV) 5 . Benzoimidazoles and their derivatives exhibit a number of important pharmacological properties, such as antihistaminic 6 , anti-ulcerative 7 , antiallergic 8 and antipyretic 9 . In addition, benzoimidazole derivatives are effective against the human cytomegalovirus (HCMV) 10 and are also efficient selective neuropeptide Y Y1 receptor antagonists 11 .…”