Escherichia Coli O:14 and Colon Hemagglutinating Antibodies in Inflammatory Bowel Disease

Wr, Thayer; Brown, Mary Louise; Mh, Sangree; Katz, Jeffrey N.; Hersh, Theodore

doi:10.1016/s0016-5085(19)33904-6

Cited by 97 publications

(15 citation statements)

References 30 publications

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“…Although antibodies to Escherichia coli have been demonstrated in the serum ofnormal subjects (Cohen and Norins, 1968;Brown and Lee, 1973), and in patients with inflammatory bowel disease (Perlmann et al, 1965;Lagercrantz et al, 1968;Thayer et al, 1969;Bull and Ignaczak, 1973;Brown and Lee, 1973), the number of serotypes previously tested have always been very few. There are 159 internationally accepted Escherichia coli serotypes and these all provide specific 0-antigens based on the heat stable lipopolysaccharide of the cell wall of the bacterium.…”

Section: Discussionmentioning

confidence: 99%

“…The possibility that antigens derived from intestinal bacterial products may cause this immune stimulation led to the consideration that the intestinal flora may play a pathogenetic role, particularly Escherichia coli 014. Escherichia coli 014 was found to have a common antigen which reacted with human colonic mucosa (Perlmann etal., 1965;Lagercrantz etal., 1968) and autoantibodies to gut mucosa could be produced by injection of bacteria (Asherson and Holborow, 1966 (Perlmann et al, 1965;Thayer et al, 1969;Bull and Ignaczak, 1973). Antigens derived from Escherichia coli 014 and another serotype, Escherichia coli 0119.K69 (B14) were also found to induce lymphocytes to become cytotoxic to colonic mucosa (Shorter et al, 1970;Bull and Ignaczak, 1973).…”

mentioning

confidence: 99%

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Escherichia coli antibodies in patients with inflammatory bowel disease.

Tabaqchali¹,

O’Donoghue²,

Bettelheim³

1978

Gut

134

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SUMMARY Sera from 30 patients with inflammatory bowel disease (IBD) (16 with Crohn's disease (CD) and 14 with ulcerative colitis (UC)) were assayed for the presence of antibodies against 159 Escherichia coli 0-antigens and compared with sera from 16 matched control subjects. The majority of patients with IBD had agglutinating antibodies to a higher number of Escherichia coli 0-antigens and in higher titres than the control group. The number of positive agglutinins was 0-33 mean 13-8 in CD, 0-26 mean 7 9 for UC, and 0-7 mean 1 5 in controls. Eight patients with IBD and arthropathy had antibodies to fewer 0-antigens (0-7 mean 3-2). The antibodies were in the IgG and IgM, in titres corresponding to original values. No specific 0-serotypes were associated with IBD. Common serotypes, R-plasmid carrying serotypes, and those associated with shigella-like adult diarrhoea were detected. 014 was detected onlyin five patients and 01 l9in none. There was no correlation between the number of Escherichia coli agglutinins and the site and severity of the disease or type of therapy.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Escherichia coli antibodies in patients with inflammatory bowel disease.

Tabaqchali¹,

O’Donoghue²,

Bettelheim³

1978

Gut

134

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show abstract

“…Many gastroenterologists feel that the two syndromes are end-organ variants of the same basic pathophysiological processes (13). Finally, recent studies (13,14) have indicated immunologic similarities between patients with UC and those with CD.…”

Section: Physical Illness and Psychosocial Characteristicsmentioning

confidence: 99%

A Psychosomatic Comparison of Patients with Ulcerative Colitis and Crohnʼs Disease

1970

Psychosomatic Medicine

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A two-phase study of 123 patients with either ulcerative colitis or Crohn's disease indicates a similarly high incidence of emotional disturbance and life crises prior to the illness onset in both somatic diseases. There are no significant differences between patients with the two diseases in a large number of demographic, psychosocial, personality, behavioral, psychiatric, and physical disease characteristics. In both syndromes, more severe emotional disturbance is associated with more severe demonstrable physical disease. The findings support the theory that these two somatic processes represent ends of a spectrum of biological response to similar psychosocial and personality factors. This study also indicates the need for early identification and treatment of emotional disturbance in both groups of patients, for which the Cornell Medical Index is a useful screening device.The clinical impression of an association between inflammatory disease of the lower intestinal tract and emotional disturbance has generated a great deal of research since Murray's original study, which suggested "psychogenic factors" in the etiology of "ulcerative colitis" (1). Most of this research, though not all, has supported the importance of psychological factors in the etiology and course of inflammatory bowel From the

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“…Either of these possibilities could result from stimulation by an aetiological agent or from an increased absorption of antigens through the intestinal epithelium secondary to inflammation and increased permeability. That such absorption occurs in inflammatory bowel disease is suggested by the presence of endotoxin in peripheral blood (Auer et al, 1978b) and by increased titres of antibodies to bacterial and dietary antigens (Thayer et al, 1969;Falchuck and Isselbacher, 1976;Schiissler et al, 1976;Wensinck, 1976).…”

Section: Discussionmentioning

confidence: 99%

Immune status in Crohn's disease : 3. Peripheral blood B lymphocytes, enumerated by means of F(ab)2-antibody fragments, Null and T lymphocytes

Auer¹,

Götz²,

Ziemer³

et al. 1979

Gut

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SUMMARY In the peripheral blood of patients with Crohn's disease (CD) the numerical distribution of the three major B lymphocyte subsets was determined by the identification of surface immunoglobulins using F(ab)2-antibody fragments. T cell counts were also obtained and the number of null cells was calculated. Twenty-eight patients with Crohn's disease including 14 patients with previously untreated and very short-standing disease (group CD 1) and 14 patients with long-standing and/or previous drug treated disease (group CD 2) were compared with 28 sex and age-matched normals as well as with 13 patients with acute inflammatory bowel disease (group D). Patients in group D and inactive patients of group CD 1 showed a significant absolute lymphocytosis due to an increase in both the three B cell subsets and the T cells, without changes in the null cells. While the proportion of T cells was normal, there was a significant relative B lymphocytosis and a relative null cytopenia in these patients. Active CD 1 patients, however, showed significantly lower absolute lymphocyte and T cell numbers. In group CD 2, there was a significant absolute lymphopenia caused by an equal decrease in B and T cells. Highly active CD 2 patients showed higher absolute null cell counts than inactive patients. With increasing disease duration there was a significant decrease of the relative and absolute B cell concentrations. The data obtained suggest that T and B cell populations in the peripheral blood are reduced in certain patients with Crohn's disease and that this occurs secondarily to activity of disease, chronicity of disease, and the effects of therapy.

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Escherichia Coli O:14 and Colon Hemagglutinating Antibodies in Inflammatory Bowel Disease

Cited by 97 publications

References 30 publications

Escherichia coli antibodies in patients with inflammatory bowel disease.

Escherichia coli antibodies in patients with inflammatory bowel disease.

A Psychosomatic Comparison of Patients with Ulcerative Colitis and Crohnʼs Disease

Immune status in Crohn's disease : 3. Peripheral blood B lymphocytes, enumerated by means of F(ab)2-antibody fragments, Null and T lymphocytes

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