Erythrocyte plasma membrane redox system in first degree relatives of type 2 diabetic patients

Rizvi, Syed Ibrahim; Srivastava, Neeti

doi:10.1016/j.ijdm.2010.05.005

Cited by 45 publications

(17 citation statements)

References 16 publications

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“…A recent study reported that DM patients had higher levels of lipid peroxidation products, uric acid, total cholesterol, LDL-cholesterol, and tryglycerides, and lower values of enzymatic antioxidants (SOD and GSH) and of HDL-cholesterol [60], confirming previous studies [61].…”

Section: Hyperglycemia As the Great Villain In Diabetes Mellitus: Indsupporting

confidence: 78%

Antioxidant defenses in diabetes mellitus: a clinical and molecular approach

Ferrari¹

2017

Integr Obesity Diabetes

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Oxidative and nitrosative stress reactions are implicated in cell and organ damage due to diabetes mellitus. In both type 1 and type 2 DM there is a massive oxidative and nitrosative stresses which have been associated with intensive changes on both antioxidant enzyme systems (SOD, CAT, GPx, GSH) and total antioxidant capacity (TAC) causing peroxidative damage to lipids, proteins, nucleic acids and carbohydrates which can be used as DM biomarkers. Molecular pathophysiology of diabetes mellitus envolves induction of the the NFkB and p38-MAPK cell signaling pathways by Rac, TNF-α, TLR4, decrease of antioxidant defenses, and direct mitochondrial damage. Knowledge of molecular pathways is essential for research of newer preventive and therapeutic approaches in diabetes mellitus complications (atherosclerosis, myocardial damage, endothelial dysfunction, and renal failure).urine, feces, tissue sample), vegetable or fruit extract or even foods or pharmaceuticals [14][15][16].This article review and update the clinical, cellular, and molecular knowledge of free radicals and antioxidant defenses in diabetes mellitus. Ethiopathogenesis of diabetes mellitus I and IIDiabetes mellitus has been conceptualized as a group of metabolic disorders characterized by hyperglicemia as a result of insulin secretion failure and/or lacking of insulin action on target cells. The chronic diabetic hyperglicemic state has been related to long-term organ damage especially to the heart, endothelium and blood vessels, nerves, kidney, and eyes [17][18][19].

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Section: Hyperglycemia As the Great Villain In Diabetes Mellitus: Indsupporting

confidence: 78%

Antioxidant defenses in diabetes mellitus: a clinical and molecular approach

Ferrari¹

2017

Integr Obesity Diabetes

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“…We present evidence that erythrocyte PMRS activity is increased in diabetic rats (Figure 4). It has already been reported that the PMRS gets elevated in type 2 diabetic human erythrocyte (Rizvi & Srivastava, 2010). A few recent studies have shown that the activity of PMRS is modulated during ageing in animals, thus providing an efficient and additional cell protection system in response to oxidative stress (Kumar & Rizvi, 2014).…”

Section: Discussionmentioning

confidence: 99%

Black tea extract improves anti-oxidant profile in experimental diabetic rats

Kumar¹,

Rizvi²

2015

Archives of Physiology and Biochemistry

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“…The importance of red cell PMRS during conditions which result in oxidative stress has recently been highlighted (Pandey & Rizvi, 2011). Its activity has been shown to be increased during aging and type 2 diabetes corresponding with decreased plasma antioxidant potential (Rizvi et al, 2006, Rizvi & Srivastava, 2010.…”

Section: Discussionmentioning

confidence: 99%

Pomegranate (Punica granatum) peel extract provides protection against mercuric chloride-induced oxidative stress in Wistar strain rats

Kumar

Singh

et al. 2013

Pharmaceutical Biology

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The results clearly demonstrate that PPE treatment augments the antioxidant defense mechanism in mercuric chloride-induced oxidant toxicity. To the best of our knowledge this is the first report of the increase in erythrocyte PMRS activity in rats after supplementation with any kind of antioxidant supplementation. This study emphasizes the need for characterizing PPE for potential unknown antioxidant compounds.

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Erythrocyte plasma membrane redox system in first degree relatives of type 2 diabetic patients

Cited by 45 publications

References 16 publications

Antioxidant defenses in diabetes mellitus: a clinical and molecular approach

Antioxidant defenses in diabetes mellitus: a clinical and molecular approach

Black tea extract improves anti-oxidant profile in experimental diabetic rats

Pomegranate (Punica granatum) peel extract provides protection against mercuric chloride-induced oxidative stress in Wistar strain rats

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