Erythrocyte indicators of oxidative stress in gestational diabetes

Abstract

Foetuses born to mothers with gestational diabetes are at increased risk of developing respiratory distress, foetal macrosomia, foetal anomalies and platelet hyperaggregability. High blood glucose level induces oxidative stress and decreases antioxidant defences. The present study discusses the possibility of lipid peroxidation and protein oxidation in both maternal and foetal erythrocytes as an indicator of oxygen radical activity. The level of lipid peroxidation and protein oxidation in erythrocytes was estimated in 20 mothers with gestational diabetes and their newborns. The maternal age varied between 19 and 42 y and foetal age ranged between 34 and 39 weeks. The proteolytic activities in the erythrocyte lysates obtained from mothers with gestational diabetes and their newborns were significantly greater [(mean ± SD) 24.41 ± 9.05 and 16.70 ± 3.36μM of amino groups/g haemoglobin, n= 20, respectively] than those from control group (10.18 ± 4.84 and 14.64 ± 6.21 μM amino groups/g haemoglobin, n= 15, respectively; p < 0:05 in both cases). Similarly erythrocyte malondialdehyde levels were significantly elevated in babies born to mothers with gestational diabetes (10.11 ±2.21 nM/g haemoglobin) when compared to controls (6.8 ± 3.75 nM/g haemoglobin) (p < 0:05). In the erythrocytes of mothers with gestational diabetes, malondialdehyde levels correlated significantly with glycated haemoglobin levels (p < 0:01). The results of this study indicate that the oxidative stress induced by gestational diabetes manifests as increased lipid peroxidation and protein oxidative damage in the erythrocytes of both mothers with gestational diabetes and their newborn infants.

Maternal and fetal indicators of oxidative stress during intrauterine growth retardation (IUGR)

“…We have previously reported increased lipid peroxidation and proteolytic activity in the erythrocytes of both mothers with gestational diabetes and their newborn infants (16) as well as during LSCS, premature rupture of membranes and prolonged second stage of labour (17). Often, fetuses born prematurely may have lowered antioxidant defenses (2).…”

N-3 Fatty acids modulate antioxidant status in diabetic rats and their macrosomic offspring

“…2 Moreover, fetuses from mothers with gestational diabetes are at increased risk of developing fetal macrosomia, platelet hyperaggregability and oxidative stress. 3 High blood glucose levels in these newborns induce oxidative stress, 3 which, in turn, induces the production of highly reactive oxygen radicals, being toxic to cells, particularly to the plasma membranes where these radicals interact with the lipid bilayer. Endogenous antioxidant enzymes (e.g.…”

Oksidatif Stresin Bir Göstergesi Olarak Protein Thioller

“…Raised glucose levels can cause oxidative stress in gestational diabetes (GDM) mothers. This may be due to the increased oxidative stress prevalent in GDM [42][43][44][45] . A significant increase in the erythrocytic GSH and protein thiols in GDM maternal blood when compared to controls have been observed.…”