Oksidatif Stresin Bir Göstergesi Olarak Protein Thioller

Abstract

ABSTRACT:Thiol is an organic compound that contain sulphhydryl group that have a critical role in preventing any involvement of oxidative stress in the cell. Among the protein defensive mechanism of the body, cysteine plays an important role in preventing an oxidative damage through its thiol functional group. These defensive functions are generally considered to be carried out by the low molecular weight thiol glutathione and by cysteine residues in the active sites of proteins such as thioredoxin and peroxiredoxin. In addition, there are thiols exposed on protein surfaces that are not directly involved with protein function, although they can interact with the intracellular environment.The process of protection of the cell against an oxidative damage occur by thiol and cystein residue that has a low molecular weight. These residue are present in the active sites of a protein like, peroxiredoxin and thioredoxin. Apart from intracellular antioxidant defense mechanism by protein thiol, there are presence of thiol in outer surface of protein that are not involved with the function of protein, even though they can interact with intracellular part of the cell. Key words: Free radicals, Thiols, antioxidants, glutathione, cysteine-SH, ÖZET Tiyol; hücrelerde herhangi bir oksitadif stres durumunun oluşumunu önlemede kritik bir role sahip sülfhidril grubunu içeren organik bir bileşiktir. Vücudun defansif protein mekanizmaları arasında yer alan sistein, içerdiği işlevsel tiyol grubu ile oksidatif hasarı önlemede önemli bir rol oynamaktadır. Bu defansif işlevler, genellikle tiyoredoksin ve peroredoksin gibi proteinlerin aktif bölgelerinde yer alan sistein depoları ve düşük moleküler ağırlığa sahip tiyol glutatyon aracılığıyla gerçekleştirilmelerine göre değerlendirilirler. İlaveten, tiyol direk olarak hücreler arası ortam ile iletişim halinde olabilmesine rağmen protein işlevinde direk olarak yer almayan protein yüzeylerinde yer almaktadır. Oksidatif

Cacao consumption improves passive avoidance memory impairment in a rat model of Alzheimer’s disease: the role of hippocampal synaptic plasticity and oxidative stress

“…In the present study, Aβ administration showed an imbalance of oxidative–antioxidative status in the plasma of the rats, which was indicated by a decrease in the concentration of TTG (as a non-enzymatic antioxidant) and an increase in the MDA level (as an indicator of lipid peroxidation), which is in congruence with previous results ( Komaki et al, 2019 ; Ahmadi et al, 2021b ). TTG contributes to the greater part of the total antioxidants found in the body and plays an essential role in defense against ROS ( Chianeh and Prabhu, 2014 ). The TTG concentration in plasma can serve as an indirect marker of antioxidant capacity ( Taysi et al, 2002 ).…”