Erythrocyte Glutathione Peroxidase Activity in Hypertensive Complications of Pregnancy

Uotila, Jukka; Tuimala, Risto; Pyykkö, Kaija

doi:10.1159/000293330

Cited by 28 publications

(10 citation statements)

References 9 publications

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“…This finding was in accordance with previous reports [23, 24] and the finding of Orhan et al [20] who reported that erythrocyte GSH-Px activity was found to be significantly increased in hypertensive preeclamptic pregnancy and in insulin-dependent diabetic pregnancy. However, there are a number of conflicting reports as well [25, 26].…”

Section: Discussionsupporting

confidence: 94%

Evaluation of Oxidative Stress and Antioxidant Status in Diabetic and Hypertensive Women during Labor

Alshebly

Mansour

2012

Oxidative Medicine and Cellular Longevity

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Pregnancy in insulin-dependent diabetes mellitus is associated with a greater incidence of fetal abnormality. Animal studies suggested that increased free-radical production and antioxidant depletion may contribute to this risk. The objective of this work was to evaluate oxidative stress and antioxidant capacity in hypertensive, diabetics, and healthy control women during labor. Simultaneous determination of antioxidant enzymes activities, namely glutathione peroxidase (GSH-Px), glutathione reductase (GSH-red), superoxide dismutase (SOD), total antioxidant, and lipid peroxides measured as thiobarbituric acid-reactive substances (TBARS) levels, were carried out in maternal plasma during labor. Plasma GSH-Px activity was found to be significantly increased as it doubled in hypertensive, and diabetic women when compared with healthy control women (P<0.05). In contrast, plasma SOD activity was significantly decreased in both groups when compared to the control group (P<0.05). No significant differences were detected in GSH-Red activity between diabetic, hypertensive and control groups. Alterations in antioxidant enzyme activities were accompanied by a significant increase in the levels of plasma lipid peroxides in hypertensive and diabetic women during labor. Plasma levels of total antioxidants were significantly increased in diabetic women as compared with the control group. Based on our results, it may be concluded that enhanced generation of oxidative stress causes alteration of antioxidant capacity in diabetic and hypertensive women during labor. Alterations in antioxidant and prooxidant components may result in various complications including peroxidation of vital body molecules which may be regarded as an increased risk factor for pregnant women as well as the fetus.

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Section: Discussionsupporting

confidence: 94%

Evaluation of Oxidative Stress and Antioxidant Status in Diabetic and Hypertensive Women during Labor

Alshebly

Mansour

2012

Oxidative Medicine and Cellular Longevity

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“…Under normal conditions there is a positive balance between antioxidant and prooxidants in various biological systems [29]. In women with preeclampsia, which is associated with oxidative stress, the levels of erythrocyte GSH-Px and erythrocyte GSH, both major LPO scavenger systems, are increased in comparison to those women having a normal pregnancy; this increase is probably compensatory [30].…”

Section: Discussionmentioning

confidence: 99%

Comparison of antioxidant enzyme activity in the internal spermatic vein and brachial veins of patients with infertile varicocele

et al. 2008

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“…7 Glutathione peroxidase (GSH-Px) activity has been reported to increase or remain unchanged, although the levels of selenium decreased. 8 Votila et al 9 observed that patients with severe preeclampsia had signi®cantly higher GSH-Px activity than those with mild preeclampsia.…”

Section: Introductionmentioning

confidence: 99%

Blood plasma levels of lipoperoxides, glutathione peroxidase, beta carotene, vitamin A and E in women with habitual abortion

Şi̇mşek

Nazıroğlu

Şimşek

et al. 1998

Cell Biochem. Funct.

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The plasma levels of lipoperoxides, glutathione peroxidase (GSH-Px), reduced glutathione (GSH), beta carotene, vitamin A, E, some plasma biochemical and blood haematological parameters were investigated in 40 women with habitual abortion (HA) and controls. The levels of GSH, vitamin A, E and beta carotene were significantly lower in women with HA than in controls. However, the plasma levels of lipid peroxidation, alkaline phosphatase (ALP), glucose and blood haemoglobin were significantly higher in HA than in controls. In addition, plasma levels of GSH-Px, AST, ALT, total bilirubin, total protein, albumin, sodium, potassium, calcium and number of white blood cells, red blood cells, platelet and values of packet cell volume showed no significant differences between HA and controls. According to the results of this study, we observed that the levels of lipid peroxidation were increased and plasma levels of vitamin A, E and beta carotene were decreased in HA. The decrease of those antioxidants may play a significant role in women with habitual abortion.

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Erythrocyte Glutathione Peroxidase Activity in Hypertensive Complications of Pregnancy

Cited by 28 publications

References 9 publications

Evaluation of Oxidative Stress and Antioxidant Status in Diabetic and Hypertensive Women during Labor

Evaluation of Oxidative Stress and Antioxidant Status in Diabetic and Hypertensive Women during Labor

Comparison of antioxidant enzyme activity in the internal spermatic vein and brachial veins of patients with infertile varicocele

Blood plasma levels of lipoperoxides, glutathione peroxidase, beta carotene, vitamin A and E in women with habitual abortion

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