Comparison of antioxidant enzyme activity in the internal spermatic vein and brachial veins of patients with infertile varicocele

Özbek, Emin; Çekmen, Mustafa; Şimşek, Abdülmuttalip; Türköz, Yusuf; Soylu, Ahmet; İlbey, Yusuf Özlem; Balbay, Mevlana Derya

doi:10.1007/s11255-008-9339-6

Cited by 11 publications

(8 citation statements)

References 29 publications

(23 reference statements)

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“…Most of the literature reported that, while ROS levels were higher in the ISV blood, the levels of antioxidants were lower compared with the peripheral venous blood [24] . Our results support the statement of Ozbek et al [28] who found the same results, namely that the activities of the antioxidant SOD and GSH-Px enzymes were significantly higher in ISV than in brachial veins. Another study has been carried out among women with preeclampsia that is associated with OS.…”

Section: Discussionsupporting

confidence: 93%

Elevation of both Reactive Oxygen Species and Antioxidant Enzymes in Vein Tissue of Infertile Men with Varicocele

Efe¹,

Kurutaş

Gul

et al. 2011

Urol Int

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Objective: To compare reactive oxygen species (ROS) and antioxidants in internal spermatic vein tissue of men with varicocele and a control group with inguinal hernia. Also to compare the levels of oxidants and antioxidants in infertile and fertile men with varicocele. Patients and Methods: 48 varicocele patients and 12 non-varicocele inguinal hernia patients participated in this study. The varicocele group was again divided into two groups – fertile men with varicocele and infertile men with varicocele. Internal spermatic vein tissue samples were obtained. The level of the malondialdehyde (MDA), an indicator of oxidative stress, and the activities of antioxidant enzymes (defense systems) against oxidative stress such as superoxide dismutase (SOD) and catalase (CAT) were estimated in these tissue samples. Results: The mean level of MDA in the varicocele group was significantly higher than in the hernia group, whereas the levels of antioxidants (SOD and CAT) were significantly lower in the varicocele group than in the hernia group. When compared with the subgroups of the varicocele group, the MDA levels and SOD and CAT activities were significantly higher in the infertile varicocele group than in the fertile varicocele group. Conclusions: Antioxidant enzyme levels generally decrease due to a high consumption in varicocele patients. On the contrary, in our study both MDA and antioxidant enzymes increased in the internal spermatic venous wall of infertile varicocele patients. This situation may be explained by an adaptation against oxidative stress in varicocele, which could be defined as a chronic process.

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Section: Discussionsupporting

confidence: 93%

Elevation of both Reactive Oxygen Species and Antioxidant Enzymes in Vein Tissue of Infertile Men with Varicocele

Efe¹,

Kurutaş

Gul

et al. 2011

Urol Int

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“…Also, the effect of increased reactive oxygen species and nitric oxide (NO) has been implicated as an important role in varicocele. Moreover, in many studies, it was found that NO level had almost nearly double level in the internal spermatic vein than in the peripheral circulation [3,4]. However, in the current study, NO was shown as lower in the internal spermatic vein than the peripheral circulation in the related Figure 2 even though there was no statistical comparison done between these parameters.…”

contrasting

confidence: 74%

The Importance of Peripheral and Local Blood Analysis for Evaluation of Nitric Oxide and Asymmetric Dimethylarginine Before and After Varicocelectomy

Çelik¹,

Çamtosun²,

Altıntaş³

2015

Biol Trace Elem Res

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“…One possible explanation of this finding was that GSH levels increased in chronic injury. Ozbek et al [33] reported that GSH levels increased in chronic injury, whereas SOD and CAT enzyme activities are elevated in the acute phase of damage. We only give methotrexate to rats for one day, so GSH levels were not affected.…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Montelukast Against Methotrexate-Induced Liver Toxicity: A Biochemical and Histological Study

Köse

Sapmaz

Sarihan

et al. 2012

The Scientific World Journal

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The effects of montelukast against methotrexate-induced liver damage were investigated. 35 Wistar albino female rats were divided into 5 groups as follows: group I: control; group II: montelukast (ML); group III: methotrexate (Mtx); group IV: montelukast treatment after methotrexate application (Mtx + ML); group V: montelukast treatment before methotrexate application (ML + Mtx). At the end of the experiment, the liver tissues of rats were removed. Malondialdehyde (MDA), myeloperoxidase (MPO), and reduced glutathione levels were determined from liver tissues. In addition, the liver tissues were examined histologically. MDA and MPO levels of Mtx group were significantly increased when compared to control group. In Mtx + ML group, these parameters were decreased as compared to Mtx group. Mtx injection exhibited major histological alterations such as eosinophilic staining and swelling of hepatocytes. The glycogen storage in hepatocytes was observed as decreased by periodic acid schiff staining in Mtx group as compared to controls. ML treatment did not completely ameliorate the lesions and milder degenerative alterations as loss of the glycogen content was still present. It was showed that montelukast treatment after methotrexate application could reduce methotrexate-induced experimental liver damage.

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Comparison of antioxidant enzyme activity in the internal spermatic vein and brachial veins of patients with infertile varicocele

Cited by 11 publications

References 29 publications

Elevation of both Reactive Oxygen Species and Antioxidant Enzymes in Vein Tissue of Infertile Men with Varicocele

Elevation of both Reactive Oxygen Species and Antioxidant Enzymes in Vein Tissue of Infertile Men with Varicocele

The Importance of Peripheral and Local Blood Analysis for Evaluation of Nitric Oxide and Asymmetric Dimethylarginine Before and After Varicocelectomy

Beneficial Effects of Montelukast Against Methotrexate-Induced Liver Toxicity: A Biochemical and Histological Study

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