Erythrocyte ferritin in normal subjects and patients with abnormal iron metabolism

Abstract

Summary. Erythrocyte ferritin is about 10 times more reactive with antibody to heart ferritin than to spleen ferritin. The concentration of erythrocyte ferritin reflects the abnormal body iron status both in iron deficiency and in idiopathic haemochromatosis. Increased concentrations in β‐thalassaemia trait and primary sideroblastic anaemia may also reflect the intrinsic erythroid abnormality. Differences in the response of ‘heart‐type’ and ‘spleen‐type’ ferritin to changes of iron status suggest possible differences in metabolic function.

Erythrocyte Ferritin in Patients on Chronic Hemodialysis Treatment

“…Clinical and biological studies suggested that eryth roblast ferritin synthesis depends on the balance between iron supply to the erythroblast and its utilization for Hb production [12][13][14], Previous studies have shown that in some pathological conditions, such as rheumatoid arthri tis and liver disease, EF could be more useful than other parameters to assess the body iron status [15,16], In this study we showed that in CHD patients both EF and SF were scattered over a wide range. A little group of CHD patients (table 1, group 3) had a consensual increase of EF and SF values in comparison with nonnephropathic sub jects: they had been frequently transfused or treated with parenteral iron in the past and an iron overload was likely to be present.…”

“…In the last years it has been found that human erythro cytes contain measurable amounts of ferritin that are correlated with body iron stores [12,13]. More recently, the biological and clinical significance of erythrocyte ferritin (EF) has been better clarified.…”

EVALUATION OF SERUM FERRITIN AND SERUM IRON IN FREE-RANGING BLACK RHINOCEROS (DICEROS BICORNIS) AS A TOOL TO UNDERSTAND FACTORS AFFECTING IRON-OVERLOAD DISORDER

“…Normal erythroblasts contain ferritin which is immunologically more similar to heart ferritin than liver ferritin (i.e., ferritin rich in H-subunits) and mean concentrations are about 10 fg ferritin protein/ cell (106). The concentration declines throughout the process of cell maturation and only about 10 ag/cell (10 -18 g/cell) remains in the erythrocyte when measured with antibodies to L-ferritin, with a somewhat higher concentration detected using antibodies to H-type ferritin (107,108). Red cell ferritin concentration has generally been measured with antibodies to L-ferritin and reflects the iron supply to the erythroid marrow.…”

Soluble transferrin receptor in sickle cell diseases: correlation with spleen function

“…Serum ferritin (SF) was determined by a fluorometric immunoenzymatic test (Stratus-Dade International Inc. -Miami, USA) and hemolyzed RCF levels were quantified by a rapid freeze-thaw method followed by a fluorometric immunoenzymatic assay. 11 The serum concentration of sTfR was measured by an immunoenzymatic technique (Quantikine R&D Systems -USA). The samples from SS and Sβthal patients were diluted 1:400 prior to assaying.…”