Erythrocyte Ferritin in Patients on Chronic Hemodialysis Treatment

Brunati, C; Piperno, Alberto; Guastoni, Carlo; Perrino, Michela; Civati, G; Teatini, Ugo; Perego, A; Fiorelli, G.; Minetti, L

doi:10.1159/000185858

Cited by 18 publications

(8 citation statements)

References 14 publications

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“…Differences were not attributable to gender in any instance (data not shown). EF values for the control population (Table 1) were comparable to those previously reported [11,12].…”

Section: Resultssupporting

confidence: 88%

Clinical relevance of erythrocyte ferritin in microcytic anemias

Vagace

Peças

Groiss

et al. 2015

Clinica Chimica Acta

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Background: Erythrocyte ferritin (EF) reflects the balance between iron supply and its utilization for hemoglobin synthesis. This balance is altered in microcytosis. We aimed to evaluate the diagnostic value of both EF and the ratio (FRR) plasma ferritin (PF)/EF in these disorders.Methods: A total of 231 subjects participated in the study. Samples from 93 adult patients with different causes of microcytosis, 57 healthy subjects and 81 full term newborns were analyzed to determine EF and PF concentrations and other hematological parameters. Results:In patients with iron deficiency, and in contrast to PF, EF decreased only in the presence of anemia and in direct correlation with the degree of microcytosis (Pearson´s p<0.001). EF values for thalassemia patients were higher than those observed in controls (p < 10e-5), whilst PF concentrations were similar between these groups .This EF increase was more marked in the delta-beta thalassemia group (p<0.05). Finally, FRR was much higher in patients with anemia of inflammation than in those with thalassemia (p<10e-5), thus helping to discriminate between these disorders.Conclusions: EF and FRR are tools that may be useful in the diagnosis of the main causes of microcytosis.

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“…Differences were not attributable to gender in any instance (data not shown). EF values for the control population (Table 1) were comparable to those previously reported [11,12].…”

Section: Resultssupporting

confidence: 88%

Clinical relevance of erythrocyte ferritin in microcytic anemias

Vagace

Peças

Groiss

et al. 2015

Clinica Chimica Acta

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“…It has been extensively documented that aluminium intoxication may cause hypochromic and microcytic anaemia as a pathogenetic factor added to chronic renal insufficiency. 26,27 Patients included in the current study showed no signs of aluminium intoxication and serum levels of this compound were relatively low. So, the effect of this factor on the differences observed between CAPD and HD patients seems unlikely.…”

Section: Discussionmentioning

confidence: 85%

“…This indicates an adequate iron supply to the erythrocytes even in patients with low iron deposits. 27 Finally, it should be noted that patients on CAPD showed lower serum ferritin concentrations and higher transferrin saturation than patients on HD in the absence of differences in iron-containing macrophages or serum levels of transferrin that may account for these findings.…”

Section: Discussionmentioning

confidence: 97%

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Anaemia of renal failure: Differences between continuous ambulatory peritoneal dialysis and haemodialysis

Fernandez¹,

Guindeo²,

Molero

et al. 2000

Nephrology

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SUMMARY: A cross‐sectional study was performed to assess a series of parameters, especially those related to iron status, that may account for differences in the anaemia of patients treated with continuous ambulatory peritoneal dialysis (CAPD) and haemodialysis (HD). Patients on CAPD (n = 37) and on haemodialysis (n = 27) were selected on the basis of clinical stability and absence of factors that may interfere with iron metabolism. Parameters measured included routine haematological and biochemical profile; serum iron metabolism (serum iron, transferrin saturation capacity, transferrin saturation index, serum ferritin); erythrocyte ferritin; bone marrow erythroid components and semiqualitative analysis of iron deposits in the bone marrow. The CAPD patients showed higher levels of haemoglobin and transferrin saturation capacity as well as lower serum ferritin than patients on haemodialysis. In the bone marrow, CAPD patients had a higher percentage of red blood cells and in those with low iron‐containing macrophages a higher percentage of sideroblasts than the haemodialysis group. Erythrocyte ferritin levels were similar in both groups. These data suggest more efficient iron metabolism in CAPD patients than in patients on haemodialysis.

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“…The utilization of EF to assess the iron status in variable conditions, and especially for patients with CRF [11, 12], outperforms SF and TS. Various factors, such as HD, CAPD, metabolism and nutrition, contribute to the variability of SF as well as of TS and render them unreliable.…”

Section: Discussionmentioning

confidence: 99%

Erythrocyte Ferritin in Patients with Chronic Renal Failure and Heterozygous Beta-Thalassemia

Christopoulou

Varsou

Travlou

et al. 2002

Nephron

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Aim: The aim of this research is to study the variance of erythrocyte ferritin (EF) in patients with chronic renal failure (CRF) and heterozygous β-thalassemia (β-TA), as well as the use of EF as a more reliable index for assessing the body iron status. Methods: We studied 63 subjects with CRF, 40 subjects with heterozygous β-TA, 53 subjects with CRF and heterozygous β-TA and 24 normal subjects. In 11 patients with CRF and heterozygous β-TA, sternal bone marrow aspiration was performed to evaluate iron stores in the bone marrow. EF was determined in the hemolysate of washed erythrocytes by a radioimmunoassay. Results: EF showed the strongest correlation with bone marrow iron (p < 0.001) in comparison with the remaining hematological parameters that were examined. Patients with CRF without heterozygous β-TA showed an increase in serum ferritin (SF), even in cases of iron deficiency. In the group of heterozygous β-TA without renal failure, 22.5% of patients showed an increased EF content up to 150 ag/cell and a tendency for iron overload. Patients with CRF and heterozygous β-TA showed a high value of EF, up to 200 ag/cell, and iron overload in 22.6%, almost the same proportion as in the previous group. It was also observed that a high value of SF does not indicate iron overload for these patients. In the group of hemodialysis, patients without heterozygous β-TA who were under erythropoietin (EPO) treatment presented iron deficiency. Many patients with CRF and heterozygous β-TA who were taking EPO presented iron overload, while very few of them presented iron deficiency. Conclusion: These findings suggest that EF is a reliable index for assessing the iron status in patients with CRF and heterozygous β-TA.

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Erythrocyte Ferritin in Patients on Chronic Hemodialysis Treatment

Cited by 18 publications

References 14 publications

Clinical relevance of erythrocyte ferritin in microcytic anemias

Clinical relevance of erythrocyte ferritin in microcytic anemias

Anaemia of renal failure: Differences between continuous ambulatory peritoneal dialysis and haemodialysis

Erythrocyte Ferritin in Patients with Chronic Renal Failure and Heterozygous Beta-Thalassemia

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