Herpetic infections are distinguished by a diverse clinical picture — this is primarily the so-called «recurrent respiratory diseases» or a recurrent variant of a chronic infectious process in the form of a so-called «mononucleosis-like syndrome,» characteristic of almost every «herpetic nosology,» persistent subfebrile condition, and febrile condition. Often, against the background of herpetic infections, various kinds of exanthems manifest, and this is not only a vesicular rash during infection with the herpes simplex virus. In practice, pediatricians often have to deal with other types of exanthems, one way or another associated with herpes infections. The article discusses 2 clinical observations of relatively unusual manifestations of chronic herpetic infections accompanied by erythema in patients aged 16 years. Photo documents of the dynamics of the skin process and laboratory parameters against the background of antiviral therapy are presented.