Erythema annulare centrifugum: a review of 24 cases with special reference to its association with underlying disease

Mahood, John M.

doi:10.1111/j.1365-2230.1983.tb01797.x

Cited by 54 publications

(23 citation statements)

References 17 publications

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“…EAC does not show predilection for sex, and pick of incidence is between 30 and 50 years of life. EAC is considered a reactive dermatosis 3,4 and bacterial, fungal and viral antigens, drugs, neoplasm, autoimmune diseases have been described as possible causative factors, 5–18 nevertheless in the majority of cases, the aetiology remains unexplained 19 . Histologically, EAC is characterized by a subacute inflammatory process with lymphocytes and occasional eosinophils around the blood vessels of the upper dermis.…”

Section: Introductionmentioning

confidence: 99%

Erythema annulare centrifugum: report of a case with neonatal onset

Bottoni

Innocenzi

Bonaccorsi

et al. 2002

Acad Dermatol Venereol

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Darier's erythema annulare centrifugum (EAC) is often associated with infectious, autoimmune or neoplastic disease, nevertheless, most cases of EAC remain unexplained. We report a case of EAC with neonatal onset and a clinical course of over 20 years. The patient presented from the 6th day of life with erythematous papules that enlarged centrifugally to form figurate, annular or policyclic plaques involving the entire cutaneous surface. The clinical picture had a chronic course, disappearing only during unrelated febrile episodes. Histologic examination revealed a normal epidermis and a dense perivascular lymphohistiocytic infiltrate and numerous eosinophils in the superficial and reticular dermis. Today the patient is 24 years old and his lesions are still unchanged. Recently, clinical evaluation revealed a diffuse sderodermic induration. A second biopsy showed a diffuse thickening of collagen fibers in the dermis. To our knowledge, this is the second report of EAC with neonatal onset and such a long and peculiar clinical course.

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Section: Introductionmentioning

confidence: 99%

Erythema annulare centrifugum: report of a case with neonatal onset

Bottoni

Innocenzi

Bonaccorsi

et al. 2002

Acad Dermatol Venereol

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“…In a large majority of cases of EAC, the etiology remains obscure, even after prolonged observation and investigation. Many different infections, inhalants, and drugs have been quite convincingly identified as causes of EAC, sometimes in only isolated case reports 2–4 . Some cases have been found in association with underlying systemic disease (e.g.…”

Section: Discussionmentioning

confidence: 99%

Erythema annulare centrifugum and pregnancy

2002

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A 28‐year‐old woman came to our attention in the 33rd week of her first pregnancy with a 2‐week history of asymptomatic skin eruptions on the arms and legs. She was otherwise well and no other symptoms were present. She used only vitamin and iron supplements during pregnancy. The eruption began as erythematous papules before spreading peripherally while clearing centrally. This produced polycyclic plaques with indurated margins and trailing scales on the inner aspect of the advancing edge. The diameter of the lesions varied from a few to several centimeters (Fig. 1). 1 Superficial erythema annulare centrifugum: a central clearing and “trailing scale” behind an advancing, annular, erythematous border Complete blood count, renal, liver, and thyroid function tests, Lyme antibody titer, antinuclear antibody test, urinary analysis, and stool examination gave normal results. A potassium hydroxide preparation and culture were negative for the presence of tinea or candidiasis. A chest X‐ray was performed after delivery and a negative result was obtained. Histology showed spongiosis associated with parakeratosis in the epidermis and a dense perivascular lymphocytic infiltrate in the upper dermis (Fig. 2). Direct immunofluorescence was negative. 2 Histopathology showing a perivascular lymphocytic infiltrate in the upper dermis (hematoxylin and eosin, × 10) At the 38th week, the patient gave birth to a healthy baby, weighing 3000 g. All skin lesions gradually disappeared within 1 month after delivery, without any treatment, except for petrolatum. No recurrence was seen after 8 months.

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“…It is characterized clinically by one or more plaques over the trunk or extremities, which enlarge by peripheral extension to form large rings with central clearing. The edges migrate slowly by several millimeters a day and the lesions disappear after a variable period of time, often to be replaced by new ones (1, 2). The histopathology demonstrates a perivascular lymphohistiocytic infiltrate in the dermis with or without epidermal changes of parakeratosis and spongiosis (1).…”

Section: Discussionmentioning

confidence: 99%