Erratum: Regulation of ITGA3 by the dual-stranded microRNA-199 family as a potential prognostic marker in bladder cancer

Sakaguchi, Takashi; Yoshino, Hirofumi; Yonemori, Masaya; Miyamoto, Kazuaki; Sugita, Sunao; Matsushita, Ryo; Iwamoto, Toshihiko; Tatarano, Shuichi; Nakagawa, Masayuki; Enokida, Hideki

doi:10.1038/bjc.2017.439

Cited by 8 publications

(1 citation statement)

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“…Integrin α3 is thought to be closely associated with the capacity of RCC for local and distant spread [47]. The same attribute has been linked to integrin β3 [48], and based on clinical specimens from tumor patients, α3 as well as β3 have been proposed as potential prognostic markers [49,50]. Evidence indicates that the integrin subtype α5 correlates with poor survival [51].…”

Section: Discussionmentioning

confidence: 98%

Low Dosed Curcumin Combined with Visible Light Exposure Inhibits Renal Cell Carcinoma Metastatic Behavior in Vitros

Rutz

Maxeiner

Justin

et al. 2020

Cancers

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Recent documentation shows that a curcumin-induced growth arrest of renal cell carcinoma (RCC) cells can be amplified by visible light. This study was designed to investigate whether this strategy may also contribute to blocking metastatic progression of RCC. Low dosed curcumin (0.2 µg/mL; 0.54 µM) was applied to A498, Caki1, or KTCTL-26 cells for 1 h, followed by exposure to visible light for 5 min (400–550 nm, 5500 lx). Adhesion to human vascular endothelial cells or immobilized collagen was then evaluated. The influence of curcumin on chemotaxis and migration was also investigated, as well as curcumin induced alterations of α and β integrin expression. Curcumin without light exposure or light exposure without curcumin induced no alterations, whereas curcumin plus light significantly inhibited RCC adhesion, migration, and chemotaxis. This was associated with a distinct reduction of α3, α5, β1, and β3 integrins in all cell lines. Separate blocking of each of these integrin subtypes led to significant modification of tumor cell adhesion and chemotactic behavior. Combining low dosed curcumin with light considerably suppressed RCC binding activity and chemotactic movement and was associated with lowered integrin α and β subtypes. Therefore, curcumin combined with visible light holds promise for inhibiting metastatic processes in RCC.

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