Low Dosed Curcumin Combined with Visible Light Exposure Inhibits Renal Cell Carcinoma Metastatic Behavior in Vitros

Rutz, Jochen; Maxeiner, Sebastian; Justin, Saira; Bachmeier, Beatrice E.; Bernd, August; Kippenberger, Stefan; Zöller, Nadja; Chun, Felix K.‐H.; Blaheta, Roman A.

doi:10.3390/cancers12020302

Cited by 12 publications

(7 citation statements)

References 59 publications

(49 reference statements)

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“…Unfortunately, its clinical application has been elusive due to its low bioavailability and instability. Recently, however, curcumin coupled with light therapy was observed to improve the compound's bioavailability in skin-related diseases [115]. In bladder cancer cell cultures, Roos et al observed that curcumin treatment followed by light exposure had enhanced antitumor properties, inhibiting cell growth and proliferation [116].…”

Section: Alternative Therapies To Support the Immune System In People With Bladder Cancermentioning

confidence: 99%

Immunotherapy in Bladder Cancer: Current Methods and Future Perspectives

Wołącewicz

Hrynkiewicz

Grywalska

et al. 2020

Cancers

180

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Bladder cancer is one of the most significant genitourinary cancer, causing high morbidity and mortality in a great number of patients. Over the years, various treatment methods for this type of cancer have been developed. The most common is the highly efficient method using Bacillus Calmette-Guerin, giving a successful effect in a high percentage of patients. However, due to the genetic instability of bladder cancer, together with individual needs of patients, the search for different therapy methods is ongoing. Immune checkpoints are cell surface molecules influencing the immune response and decreasing the strength of the immune response. Among those checkpoints, the PD-1 (programmed cell death protein-1)/PD-L1 (programmed cell death protein ligand 1) inhibitors aim at blocking those molecules, which results in T cell activation, and in bladder cancer the use of Atezolizumab, Avelumab, Durvalumab, Nivolumab, and Pembrolizumab has been described. The inhibition of another pivotal immune checkpoint, CTLA-4 (cytotoxic T cell antigen), may result in the mobilization of the immune system against bladder cancer and, among anti-CTLA-4 antibodies, the use of Ipilimumab and Tremelimumab has been discussed. Moreover, several different approaches to successful bladder cancer treatment exists, such as the use of ganciclovir and mTOR (mammalian target of rapamycin) kinase inhibitors, IL-12 (interleukin-12) and COX-2 (cyclooxygenase-2). The use of gene therapies and the disruption of different signaling pathways are currently being investigated. Research suggests that the combination of several methods increases treatment efficiency and the positive outcome in individual.

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Section: Alternative Therapies To Support the Immune System In People With Bladder Cancermentioning

confidence: 99%

Immunotherapy in Bladder Cancer: Current Methods and Future Perspectives

Wołącewicz

Hrynkiewicz

Grywalska

et al. 2020

Cancers

180

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“…Interestingly, light irradiation could enhance the biological effects of curcumin. Low-dose curcumin plus visible light exposure could significantly inhibit metastatic processes of renal cell carcinoma [ 267 ], and light exposure might also enhance its efficacy in bladder cancer cell lines [ 268 ]. Exposure to light also enhanced its anti-microbial capacity because of curcumin phototoxicity in bacterial cells [ 269 ].…”

Section: Resultsmentioning

confidence: 99%

Insight into the Progress on Natural Dyes: Sources, Structural Features, Health Effects, Challenges, and Potential

Wang

Zhou

et al. 2022

Molecules

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(1) Background: Dyes play an important role in food, medicine, textile, and other industries, which make human life more colorful. With the increasing demand for food safety, the development of natural dyes becomes more and more attractive. (2) Methods: The literature was searched using the electronic databases PubMed, Web of Science, and SciFinder and this scoping review was carried out following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). (3) Results: 248 articles were included in this review. This review summarizes the research progress on natural dyes in the last ten years. According to structural features, natural dyes mainly include carotenoids, polyphenols, porphyrins, and alkaloids, and some of the newest dyes are summarized. Some pharmacological activities of carotenoids, anthocyanin, curcumin, and betalains in the last 10 years are summarized, and the biological effects of dyes regarding illumination conditions. The disadvantages of natural dyes, including sources, cost, stability, and poor bioavailability, limit their application. Here, some feasible strategies (potential resources, biotechnology, new extraction and separation strategies, strategies for improving stability) are described, which will contribute to the development and utilization of natural dyes. (4) Conclusion: Natural dyes show health benefits and potential in food additives. However, it is necessary for natural dyes to pass toxicity tests and quality tests and receive many regulatory approvals before their final entry into the market as food colorants or as drugs.

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“…Light also improves curcumin's bioavailability in skin keratinocytes [22] and renal [23] and bladder cancer cells [24], pointing to a mechanism common to different cancer types.…”

Section: Discussionmentioning

confidence: 99%

“…The photodynamic influence on curcumin described here is not restricted to prostate cancer. Light also improves curcumin’s bioavailability in skin keratinocytes [ 22 ] and renal [ 23 ] and bladder cancer cells [ 24 ], pointing to a mechanism common to different cancer types.…”

Section: Discussionmentioning

confidence: 99%

Growth, Proliferation and Metastasis of Prostate Cancer Cells Is Blocked by Low-Dose Curcumin in Combination with Light Irradiation

Rutz

Benchellal

Kassabra

et al. 2021

IJMS

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Although anti-cancer properties of the natural compound curcumin have been reported, low absorption and rapid metabolisation limit clinical use. The present study investigated whether irradiation with visible light may enhance the inhibitory effects of low-dosed curcumin on prostate cancer cell growth, proliferation, and metastasis in vitro. DU145 and PC3 cells were incubated with low-dosed curcumin (0.1–0.4 µg/mL) and subsequently irradiated with 1.65 J/cm2 visible light for 5 min. Controls remained untreated and/or non-irradiated. Cell growth, proliferation, apoptosis, adhesion, and chemotaxis were evaluated, as was cell cycle regulating protein expression (CDK, Cyclins), and integrins of the α- and β-family. Curcumin or light alone did not cause any significant effects on tumor growth, proliferation, or metastasis. However, curcumin combined with light irradiation significantly suppressed tumor growth, adhesion, and migration. Phosphorylation of CDK1 decreased and expression of the counter-receptors cyclin A and B was diminished. Integrin α and β subtypes were also reduced, compared to controls. Irradiation distinctly enhances the anti-tumor potential of curcumin in vitro and may hold promise in treating prostate cancer.

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Low Dosed Curcumin Combined with Visible Light Exposure Inhibits Renal Cell Carcinoma Metastatic Behavior in Vitros

Cited by 12 publications

References 59 publications

Immunotherapy in Bladder Cancer: Current Methods and Future Perspectives

Immunotherapy in Bladder Cancer: Current Methods and Future Perspectives

Insight into the Progress on Natural Dyes: Sources, Structural Features, Health Effects, Challenges, and Potential

Growth, Proliferation and Metastasis of Prostate Cancer Cells Is Blocked by Low-Dose Curcumin in Combination with Light Irradiation

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