Interference with circBC048201 inhibits the proliferation, migration, and invasion of bladder cancer cells through the miR-1184/ITGA3 axis

Jiang, Peng; Zhu, Yi; Xu, Zhijie; Chen, Xiaoyi; Xie, Liping

doi:10.1007/s11010-020-03835-2

Cited by 12 publications

(7 citation statements)

References 39 publications

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“…For instance, miR-1184 inhibited tumor cells growth, migration, and invasion in bladder cancer and colorectal cancer. 43,44 miR-548I could inhibit cells proliferation in HCC. 45 Intriguingly, our study found that miR-1184/miR-548I could inhibit the invasion and migration in NSCLC cells.…”

Section: Discussionmentioning

confidence: 98%

Hsa_circ_0001666 promotes non-small cell lung cancer migration and invasion through miR-1184/miR-548I/AGO1 axis

Wang

Feng

et al. 2022

Molecular Therapy - Oncolytics

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Section: Discussionmentioning

confidence: 98%

Hsa_circ_0001666 promotes non-small cell lung cancer migration and invasion through miR-1184/miR-548I/AGO1 axis

Wang

Feng

et al. 2022

Molecular Therapy - Oncolytics

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“…Furthermore, miR-1184 suppressed cell proliferation, migration, and invasion via targeting ajuba LIM protein (AJUBA) in colorectal cancer [31]. Moreover, miR-1184 could repress proliferation, migration, and invasion through modulating insulin-like growth factor binding protein 2 (IGFBP2) or integrin α3 (ITGA3) in BC [13, 32]. In accordance with previous research, miR-1184 acted as a tumor suppressor in BC by regulating cell proliferation, migration, invasion, and angiogenesis.…”

Section: Discussionmentioning

confidence: 99%

Hsa_circ_0008035 Knockdown Inhibits Bladder Cancer Progression through miR-1184/RAP2B Axis

Liu

Jiang

et al. 2023

Urol Int

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Introduction: Circular RNAs (circRNAs) are related to the pathogenesis and progression of bladder cancer (BC). This research aimed to investigate the role and mechanism of hsa_circ_0008035 (circ_0008035) in BC progression. Methods: Circ_0008035, microRNA (miR)-1,184, and Ras-related protein 2B (RAP2B) levels were examined in BC via quantitative real-time polymerase chain reaction and Western blotting. Cell Counting Kit-8, colony formation, 5-ethynyl-2′-deoxyuridine staining, flow cytometry, caspase-3 assay kit, transwell, and tube formation assays were conducted to estimate the effects of circ_0008035 on the malignant phenotypes of BC tumors. The interaction between RNAs and genes was evaluated via a dual-luciferase reporter and RNA immunoprecipitation assays. A xenograft model of BC in nude mice was established to estimate the effect of circ_0008035 in BC in vivo. Results: Circ_0008035 and RAP2B levels were upregulated, while miR-1184 abundance was downregulated in BC tissues and cells. Circ_0008035 knockdown constrained cell proliferation, migration, invasion and angiogenesis but promoted apoptosis in vitro. And circ_0008035 silencing curbed xenograft tumor growth in vivo. Circ_0008035 acted as a miRNA sponge for miR-1184. Circ_0008035 increased RAP2B expression by sponging miR-1184. MiR-1184 downregulation relieved the effects of circ_0008035 knockdown on BC progression. And RAP2B knockdown partly reversed the effects of miR-1184 overexpression on BC progression. Conclusion: Circ_0008035-mediated BC progression via regulating the miR-1184/RAP2B axis, providing a potential target for BC treatment.

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“…In colorectal cancer, the overexpression of this miRNA inhibits cell proliferation and promotes apoptosis by circular RNA hsa_circ_0128,846 ( Chen S. et al, 2020 ), whereas in triple-negative breast cancer (TNBC) subtype tissue and cell lines it is linked to enhanced proliferation, migration and invasion by circular RNA lar hsa_circ_0000732 ( Chen et al, 2022 ). Furthermore, the downregulation of this miRNA promotes tumorigenesis ( Wang et al, 2020a ) in colorectal cancer through IGFBP2 and ITGA3 genes, and in bladder cancer, it is associated with accelerated tumor progression ( Jiang P. et al, 2020 ; Yang et al, 2020 ), hsa-miR-1184 has been proposed as a potential serum biomarker to distinguish between benign prostatic hyperplasia (BPH) and prostate cancer ( Knyazev et al, 2016 ). Thus, hsa-miR-1184 is an interesting target for further studies on its regulatory role in cancer-related processes.…”

Section: Discussionmentioning

confidence: 99%

Impact of MICA 3′UTR allelic variability on miRNA binding prediction, a bioinformatic approach

Toledo-Stuardo,

Ribeiro,

Campos

et al. 2023

Front. Genet.

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MicroRNAs (miRNAs) are small non-coding RNAs that participate as powerful genetic regulators. MiRNAs can interfere with cellular processes by interacting with a broad spectrum of target genes under physiological and pathological states, including cancer development and progression. Major histocompatibility complex major histocompatibility complex class I-related chain A (MICA) belongs to a family of proteins that bind the natural-killer group 2, member D (NKG2D) receptor on Natural Killer cells and other cytotoxic lymphocytes. MICA plays a crucial role in the host’s innate immune response to several disease settings, including cancer. MICA harbors various single nucleotide polymorphisms (SNPs) located in its 3′-untranslated region (3′UTR), a characteristic that increases the complexity of MICA regulation, favoring its post-transcriptional modulation by miRNAs under physiological and pathological conditions. Here, we conducted an in-depth analysis of MICA 3′UTR sequences according to each MICA allele described to date using NCBI database. We also systematically evaluated interactions between miRNAs and their putative targets on MICA 3′UTR containing SNPs using in silico analysis. Our in silico results showed that MICA SNPs rs9266829, rs 1880, and rs9266825, located in the target sequence of miRNAs hsa-miR-106a-5p, hsa-miR-17-5p, hsa-miR-20a-5p, hsa-miR-20b-5p, hsa-miR-93, hsa-miR-1207.5p, and hsa-miR-711 could modify the binding free energy between −8.62 and −18.14 kcal/mol, which may affect the regulation of MICA expression. We believe that our results may provide a starting point for further exploration of miRNA regulatory effects depending on MICA allelic variability; they may also be a guide to conduct miRNA in silico analysis for other highly polymorphic genes.

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Interference with circBC048201 inhibits the proliferation, migration, and invasion of bladder cancer cells through the miR-1184/ITGA3 axis

Cited by 12 publications

References 39 publications

Hsa_circ_0001666 promotes non-small cell lung cancer migration and invasion through miR-1184/miR-548I/AGO1 axis

Hsa_circ_0001666 promotes non-small cell lung cancer migration and invasion through miR-1184/miR-548I/AGO1 axis

Hsa_circ_0008035 Knockdown Inhibits Bladder Cancer Progression through miR-1184/RAP2B Axis

Impact of MICA 3′UTR allelic variability on miRNA binding prediction, a bioinformatic approach

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