Eradication Therapy in &lt;i&gt;Helicobacter pylori&lt;/i&gt;-Positive Patients with Halitosis: Long-Term Outcome

Katsinelos, Panagiotis; Tziomalos, Kostas; Chatzimavroudis, Grigoris; Vasiliadis, Themistoklis; Katsinelos, Taxiarchis; Pilpilidis, Ioannis; Triantafillidis, I.; Paroutoglou, George; Papaziogas, B.

doi:10.1159/000098364

Cited by 43 publications

(42 citation statements)

References 34 publications

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“…http://ginsengres.org ment of halitosis with eradication of H. pylori [44,45]. Lee et al [46] first reported production of VSCs by H. pylori.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Korean Red Ginseng Supplementation on Eradication Rate and Gastric Volatile Sulfur Compound Levels after Helicobacter pylori Eradication Therapy

Lee¹,

Park²,

Choi³

et al. 2010

Journal of Ginseng Research

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This clinical study was performed to evaluate whether supplementation of proton pump inhibitor (PPI)-based triple therapy with Korean red ginseng can enhance Helicobacter pylori (H. pylori) eradication and reduce levels of halitosis-associated volatile sulfur compounds (VSCs) in the stomach. Seventy-six patients were randomized into an eradication regimen-only group (n=45) or an eradication regimen plus 10 weeks of Korean red ginseng supplementation group (n=31). The eradication regimen consisted of PPI b.i.d., clarithromycin 500 mg b.i.d., and amoxicillin 1 g b.i.d.. for seven days. Korean red ginseng supplementation commenced on the last day of the eradication regimen.13 C-urea breath test and halimeter measurements were performed prior to protocol repetition. By intention-to-treat analysis, the H. pylori eradication rate in the Korean red ginseng group (77.4%, 24 of 31) was higher than that in the control group (45.0%, 26 of 45). However, by per protocol analysis, the eradication rate in the Korean red ginseng group was significantly higher than that in the control group (92.3%, 24/26 vs. 69.4%, 26/38; p<0.05). H. pylori infection was significantly associated with increased VSC levels. However, VSC levels decreased significantly in the Korean red ginseng group (p<0.05). In conclusion, supplementation of triple therapy with Korean red ginseng increased the H. pylori eradication rate and led to significant reductions in VSC levels, suggesting the usefulness of this substance in combating H. pylori infection.

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“…http://ginsengres.org ment of halitosis with eradication of H. pylori [44,45]. Lee et al [46] first reported production of VSCs by H. pylori.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Korean Red Ginseng Supplementation on Eradication Rate and Gastric Volatile Sulfur Compound Levels after Helicobacter pylori Eradication Therapy

Lee¹,

Park²,

Choi³

et al. 2010

Journal of Ginseng Research

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“…However, there is still a lack of critical evidence that associates gastrointestinal disease with halitosis except for a Helicobacter pylori infection [6,7,8], which does have some links to halitosis symptoms. Lee et al [6] showed that H. pylori directly produced volatile sulfur compounds (VSCs) with the addition of cysteine in culture media and Katsinelos et al [9] reported that the eradication of H. pylori in patients with functional dyspepsia led to a sustained resolution of halitosis during long-term follow-up.…”

Section: Introductionmentioning

confidence: 99%

Korea Red Ginseng on Helicobacter pylori-Induced Halitosis: Newer Therapeutic Strategy and a Plausible Mechanism

et al. 2009

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Background: Gas chromatographic documentation of volatile sulfur compounds in Helicobacter pylori cultures and the amelioration of halitosis after eradication suggested a causal link between H. pylori infection and halitosis. Aim: We hypothesized that Korea red ginseng can relieve H. pylori-associated halitosis based on their anti-inflammatory and cytoprotective actions in H. pylori-associated gastritis. Methods: Eighty-eight functional dyspepsia patients presenting with either subjective halitosis or objective halimeter levels >100 ppb were recruited, on whom tests were repeated after 10 weeks of red ginseng administration. The expressions of cystathionine γ-lyase (CSE), cystathionine β-synthetase (CBS), IL-6, IL-8 and IL-1β mRNA were compared in H. pylori-infected or NaHS-treated gastric epithelial cells according to red ginseng treatment. Results: After 10 weeks of red ginseng administration, 38 patients out of 68 H. pylori-positive cases became ‘free of halitosis’ accompanied with halimeter levels <50 ppb accordant with the subjective resolution of halitosis. Among the remaining 30 patients, 15 cases administered with both eradication regimen and red ginseng supplement showed either higher eradication rates (93.3%) or were found to be completely free of halitosis in comparison to the other 15 patients who were only administered the eradication regimen. Among 20 H. pylori-negative patients, 13 patients became ‘free of halitosis’ with 10 weeks of red ginseng treatment alone. Red ginseng extracts significantly decreased H. pylori- or NaHS-induced CSE expressions concomitant with attenuated levels of IL-6, IL-8 and IL-1β mRNA. Conclusion: The strategy consisting of Korea red ginseng supplementation after the successful eradication of H. pylori could be an effective way to fight troublesome halitosis.

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“…In detail, some studies revealed that halitosis was quite prevalent in H. pylori positive group and others showed that halitosis was improved after the eradication therapy of H. pylori. [6][7][8][9][10] H. pylori infection was responsible for volatile sulfur compounds (VSCs) production, known as causative constituents of halitosis. VSCs, composed of hydrogen sulfide, methyl mercaptan, and dimethyl sulfide, have been known as the main factor of halitosis.…”

Section: Introductionmentioning

confidence: 99%

Volatile Sulfur Compounds as a Predictor for Esophagogastroduodenal Mucosal Injury

Yoo

Jung²,

Sohn³

et al. 2008

Gut Liver

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Background/Aims: Halitosis is a symptom that bothers patients more socially than medically and its pathogenic mechanisms are unclear and treatment armamenterium is limited. Clinicians generally ignored active interventions. Since halitosis is closely associated with volatile sulfur compounds (VSCs), we used a Halimeter and gas chromatography to measure VSCs in patients with Helicobacter-pylori (H. pylori)-associated gastric diseases. Methods: We categorized 72 patients with H. pylori infection into two groups based on their endoscopic findings: a nonerosive mucosal group (NE, n=24) and an erosive mucosal group (E, n=48). Halitosis was objectively assessed by applying either a Halimeter to breath air or gas chromatography to gastric juice. Simultaneously, the expression of VSC-generating enzyme was measured with reverse-transcriptase PCR using mRNA isolated from biopsy tissues. Results: The levels of VSCs in exhaled breaths or aspirated gastric juices differed significantly between the NE and E groups (p ＜0.00001), suggesting that VSCs might reflect eroded epithelial damage induced by H. pylori infection. The expressions of cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE) were broadly consistent with the degree of mucosal injury. Conclusions: Erosive changes in esophagogastroduodenal mucosa were strongly correlated with increased VSC levels, suggesting that halitosis might result from H. pylori-associated erosive lesions. (Gut and Liver 2008;2: 113-118)

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Eradication Therapy in <i>Helicobacter pylori</i>-Positive Patients with Halitosis: Long-Term Outcome

Cited by 43 publications

References 34 publications

Efficacy of Korean Red Ginseng Supplementation on Eradication Rate and Gastric Volatile Sulfur Compound Levels after Helicobacter pylori Eradication Therapy

Efficacy of Korean Red Ginseng Supplementation on Eradication Rate and Gastric Volatile Sulfur Compound Levels after Helicobacter pylori Eradication Therapy

Korea Red Ginseng on Helicobacter pylori-Induced Halitosis: Newer Therapeutic Strategy and a Plausible Mechanism

Volatile Sulfur Compounds as a Predictor for Esophagogastroduodenal Mucosal Injury

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