Volatile Sulfur Compounds as a Predictor for Esophagogastroduodenal Mucosal Injury

Yoo, Seung Hee; Jung, Hyeon Sik; Sohn, Wee Sik; Kim, Bong Hwan; Ku, Bon Ho; Kim, Young Saeng; Park, Sang Woon; Hahm, Ki‐Baik

doi:10.5009/gnl.2008.2.2.113

Cited by 26 publications

(26 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Data from a previous study [23] suggested that breath VSC levels indicated the presence of erosive or mucosal injury in patients with functional dyspepsia. Thus, to determine the effects of H. pylori infection on VSC levels, we recruited 55 subjects with functional dyspepsia.…”

Section: H Pylori Infection and Vsc Levelsmentioning

confidence: 93%

Efficacy of Korean Red Ginseng Supplementation on Eradication Rate and Gastric Volatile Sulfur Compound Levels after Helicobacter pylori Eradication Therapy

Lee¹,

Park²,

Choi³

et al. 2010

Journal of Ginseng Research

Self Cite

View full text Add to dashboard Cite

This clinical study was performed to evaluate whether supplementation of proton pump inhibitor (PPI)-based triple therapy with Korean red ginseng can enhance Helicobacter pylori (H. pylori) eradication and reduce levels of halitosis-associated volatile sulfur compounds (VSCs) in the stomach. Seventy-six patients were randomized into an eradication regimen-only group (n=45) or an eradication regimen plus 10 weeks of Korean red ginseng supplementation group (n=31). The eradication regimen consisted of PPI b.i.d., clarithromycin 500 mg b.i.d., and amoxicillin 1 g b.i.d.. for seven days. Korean red ginseng supplementation commenced on the last day of the eradication regimen.13 C-urea breath test and halimeter measurements were performed prior to protocol repetition. By intention-to-treat analysis, the H. pylori eradication rate in the Korean red ginseng group (77.4%, 24 of 31) was higher than that in the control group (45.0%, 26 of 45). However, by per protocol analysis, the eradication rate in the Korean red ginseng group was significantly higher than that in the control group (92.3%, 24/26 vs. 69.4%, 26/38; p<0.05). H. pylori infection was significantly associated with increased VSC levels. However, VSC levels decreased significantly in the Korean red ginseng group (p<0.05). In conclusion, supplementation of triple therapy with Korean red ginseng increased the H. pylori eradication rate and led to significant reductions in VSC levels, suggesting the usefulness of this substance in combating H. pylori infection.

show abstract

Section: H Pylori Infection and Vsc Levelsmentioning

confidence: 93%

Efficacy of Korean Red Ginseng Supplementation on Eradication Rate and Gastric Volatile Sulfur Compound Levels after Helicobacter pylori Eradication Therapy

Lee¹,

Park²,

Choi³

et al. 2010

Journal of Ginseng Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…As result, we speculated that halitosis could be the extraesophageal manifestation of ERD, but it might be the results of the presence of esophageal mucosal damages, similar result with our previous publication. 13 Therefore, we assert that minimal change lesion could be a part of ERD rather than NERD in its nature determined by the nature of Halimeter ppb reflecting the presence of mucosal injury. The mean ppb levels in NERD patients with hiatal hernia were 191.11±32.55 and the levels of ppb in NERD without hiatal hernia were 121.59±13.69, of which statistical difference was significant (p=0.029).…”

Section: Resultsmentioning

confidence: 80%

“…11,12 In a previous study, we measured VSCs among the patients who had injured gastric mucosa, checking VSC levels by Halimeter of oral air or gas chromatography of gastric juice, and reached to the conclusion that halitosis might have significant correlation with mucosal damage after Helicobacter pylori (H. pylori) infection. 13 The core points we have found from this previous study was that the injured esophagogastroduodenal mucosa have potential of generating VSCs supported with the fact that there was statistical difference in VSC levels between eroded esophageal mucosa and noneroded mucosa. Additional report was followed that Korea red ginseng could relieve halitosis through their anti-inflammatory and cytoprotective actions in patients with H. pylori-infected gastritis.…”

Section: Introductionmentioning

confidence: 64%

Halimeter ppb Levels as the Predictor of Erosive Gastroesophageal Reflux Disease

Kim¹,

Kim²,

Yoo³

et al. 2010

Gut Liver

Self Cite

View full text Add to dashboard Cite

Background/Aims: In a previous issue published inGut and Liver, we found that erosive changes in the esophagogastroduodenal mucosa were strongly correlated with increased levels of volatile sulfur-containing compounds (VSC), suggesting that halitosis could be a symptom reflecting the erosive status of the upper gut mucosa. Together with other studies showing a possible association between halitosis and gastroesophageal reflux disease (GERD), under the premise that halitosis could be one of extraesophageal manifestations of erosive GERD (ERD), we investigated the significance of Halimeter ppb levels on ERD compared to non-erosive gastroesophageal reflux disease (NERD). Methods: Subjects were assigned to the NERD group if there was no evidence of esophageal erosive changes on endoscopy, despite reflux symptoms, and to the ERD group if they had GERD A, B, C, or D (according to the Los Angeles classification). The VSC levels were measured in all patients with either a Halimeter (before endoscopy) or by gas chromatography of the gastric juices aspirated during endoscopy. Results: The VSC level differed significantly between the NERD and ERD groups (p ＜0.0001), suggesting that this can be used to discriminate between NERD and ERD. However, the VSC level did not differ significantly with the severity of GERD. Even though hiatal hernia and a body mass index of ＞24 kg/m 2 was significantly associated with ERD, there was no correlation with Halimeter ppb levels. Minimal-change lesions exhibited the highest VSC levels, signifying that minimal change lesions can be classified as ERD based on our finding that halimeter ppb levels were descrimitive of erosive change. Conclusions: Erosive changes in the esophageal mucosa were strongly associated with VSC levels, supporting the hypothesis that halitosis can be a potential biomarker for the discrimination between ERD and NERD, reflecting the presence of erosive change in the lower esophagogastric junction. (Gut Liver 2010;4:320-325)

show abstract

“…5,14 However, other studies have proposed a significant relationship between halitosis and GERD (Table 4). [16][17][18][19]29 16,29 In these studies, the erosive reflux disease group had higher VSC values than the NERD group. However, these studies lacked a true control group, such as healthy subjects.…”

Section: Discussionmentioning

confidence: 78%

Association Between Halitosis Diagnosed by a Questionnaire and Halimeter and Symptoms of Gastroesophageal Reflux Disease

Lee¹,

Kim²,

Kim³

et al. 2014

J Neurogastroenterol Motil

View full text Add to dashboard Cite

Background/Aims The relationship between halitosis and gastroesophageal reflux disease (GERD) remains controversial. The aim of this study was to investigate an association between subjective and objective halitosis and GERD. Methods The subjects were enrolled from participants who visited a health promotion center at Seoul National University Bundang Hospital. For diagnosis of halitosis, a questionnaire was requested, and volatile sulfur compounds (VSCs) were measured by Halimeter. Self-conscious halitosis was defined as halitosis perceived by himself or herself. Informed halitosis was defined as halitosis perceived by others. Objective halitosis was defined when mean VSCs values were > 100 parts per billion. GERD was defined based on a questionnaire and endoscopy, including erosive esophagitis and non-erosive reflux disease (NERD). Results A total of 54 subjects (male:female = 33:21) with mean age of 46.0 ± 11.4 years were analyzed. The mean VSCs values were not significantly different between presence and absence of self-conscious halitosis ( P = 0.322), but significantly different between presence and absence of informed halitosis ( P = 0.021). Informed halitosis was associated with objective halitosis ( P = 0.039). GERD, erosive esophagitis and NERD did not correlate with objective halitosis ( P = 0.556, 0.206 and 0.902, respectively). In multivariable analysis, the relationship between objective halitosis and GERD symptoms including chest pain, heart burn, acid regurgitation, epigastric pain, hoarseness, globus sensation and coughing was not significant. Besides, GERD was not associated with self-conscious halitosis, informed halitosis and objective halitosis, respectively. Conclusions GERD might not be associated with self-conscious, informed halitosis and objective halitosis indicated by Halimeter results. Informed halitosis could be correlated with objective halitosis determined by the Halimeter.

show abstract

Volatile Sulfur Compounds as a Predictor for Esophagogastroduodenal Mucosal Injury

Cited by 26 publications

References 21 publications

Efficacy of Korean Red Ginseng Supplementation on Eradication Rate and Gastric Volatile Sulfur Compound Levels after Helicobacter pylori Eradication Therapy

Efficacy of Korean Red Ginseng Supplementation on Eradication Rate and Gastric Volatile Sulfur Compound Levels after Helicobacter pylori Eradication Therapy

Halimeter ppb Levels as the Predictor of Erosive Gastroesophageal Reflux Disease

Association Between Halitosis Diagnosed by a Questionnaire and Halimeter and Symptoms of Gastroesophageal Reflux Disease

Contact Info

Product

Resources

About