Efficacy of Korean Red Ginseng Supplementation on Eradication Rate and Gastric Volatile Sulfur Compound Levels after Helicobacter pylori Eradication Therapy

Abstract

This clinical study was performed to evaluate whether supplementation of proton pump inhibitor (PPI)-based triple therapy with Korean red ginseng can enhance Helicobacter pylori (H. pylori) eradication and reduce levels of halitosis-associated volatile sulfur compounds (VSCs) in the stomach. Seventy-six patients were randomized into an eradication regimen-only group (n=45) or an eradication regimen plus 10 weeks of Korean red ginseng supplementation group (n=31). The eradication regimen consisted of PPI b.i.d., clarithromycin 500 mg b.i.d., and amoxicillin 1 g b.i.d.. for seven days. Korean red ginseng supplementation commenced on the last day of the eradication regimen.13 C-urea breath test and halimeter measurements were performed prior to protocol repetition. By intention-to-treat analysis, the H. pylori eradication rate in the Korean red ginseng group (77.4%, 24 of 31) was higher than that in the control group (45.0%, 26 of 45). However, by per protocol analysis, the eradication rate in the Korean red ginseng group was significantly higher than that in the control group (92.3%, 24/26 vs. 69.4%, 26/38; p<0.05). H. pylori infection was significantly associated with increased VSC levels. However, VSC levels decreased significantly in the Korean red ginseng group (p<0.05). In conclusion, supplementation of triple therapy with Korean red ginseng increased the H. pylori eradication rate and led to significant reductions in VSC levels, suggesting the usefulness of this substance in combating H. pylori infection.

Ginseng for Health Care: A Systematic Review of Randomized Controlled Trials in Korean Literature

“…Twenty-eight trials originated from Korea [28]–[55], and two trials were conducted in Thailand [26] and the United Kingdom [27]. Sixteen studies [28], [32]–[41], [44]–[47], [53] were published in Korean, and 14 trials [26], [27], [29]–[31], [42], [43], [48]–[52], [54], [55] were written in English.…”

“…The key data from studies in healthy persons are summarised in Table 1 [26]–[34], and the data regarding other various conditions are summarised in Table 2 [35]–[55]. The included RCTs used ginseng powder either in raw (4 studies) [35], [38], [53], [55] or in capsules (22 studies) [26]–[29], [31], [32], [34], [36], [37], [39]–[41], [43]–[48], [50]–[52], [54] and extract preparation (2 studies) [33], [42], while two studies [30], [49] did not report the preparation type of ginseng. They addressed a wide range of conditions: generally healthy (i.e., studies in healthy individuals) [26]–[34], erectile dysfunction [35]–[40], gastric cancer [41], [43], colon cancer [42], gastrointestinal carcinoma [44], chronic gastritis [45], diabetes mellitus [46], [47], androgenic alopecia [48], coronary artery [49], dry mouth [50], glaucoma [51], obesity [52], metabolic syndrome [53], dyspepsia and indigestion [54] and Alzheimer’s disease [55].…”

Src and Syk are targeted to an anti-inflammatory ethanol extract of Aralia continentalis

“…Inflammation of the stomach was induced with EtOH/HCl according to a published method (Lee et al, 2010b;Okabe et al, 1986). Fasted ICR mice were orally treated with Ac-EE (200 mg/kg) or ranitidine (40 mg/kg) twice per day for three days.…”

Chemoprevention of Gastrointestinal Cancer: The Reality and the Dream

“…Besides these synthetic products, a large body of evidence suggests that regular consumption of fruits and vegetables can prevent different forms of GI cancers (Table 1). 74-132 Because it is estimated that two thirds to three quarters of gastric cancer worldwide are associated with H. pylori infection,133 it seems that the eradication of H. pylori and the control of gastric inflammation induced by the pathogen are essential in the prevention of gastric cancer. Previous our studies have shown that Korea red ginseng could rescue H. pylori -induced cytotoxicity,76 suppress H. pylori -induced 5-lipoxygenase pathway,77 and attenuate gastric inflammation through augmented eradication rates of H. pylori in the clinical study 78.…”