Eradication of poliomyelitis

Wiysonge, Charles Shey; Njamnshi, Alfred K.; Nomo, E; Shey, Muki

doi:10.1016/s0140-6736(05)67477-6

Cited by 9 publications

(7 citation statements)

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“…The proportion of children who receive the full series of three doses of diphtheria-tetanus-pertussis containing vaccines (DTP3) by 12 months of age is traditionally used as a standard measure of the programme's ability to reach the target population, and is used as an indicator of the overall performance of EPI programmes ( Okwo-Bele 2011 ; WHO-UNICEF 2009 ). The traditional EPI vaccines are estimated to prevent 2.5 million child deaths annually (mainly from measles, pertussis, tetanus, and diphtheria), as well as to prevent severe morbidity for millions more children around the world from devastating diseases such as poliomyelitis and tuberculous meningitis (CDC 1999 ; Liu 2012 ; Machingaidze 2013a ; Okwo-Bele 2011 ; Rainey 2011 ; Wiysonge 2005 ). However, immunisation has the potential to do more; increasing coverage with existing vaccines, as well as the introduction and increased uptake of a portfolio of newly available vaccines in EPI programmes in low- and middle-income countries (LMICs), could save the lives of millions more children each year (Andre 2008 ; Brown 2011 ; Chopra 2013 ; Duclos 2009 ; Liu 2012 ; Machingaidze 2013a ; WHO-UNICEF 2009 ; Wiysonge 2012a ).…”

Section: Introductionmentioning

confidence: 99%

Interventions for improving coverage of childhood immunisation in low- and middle-income countries

Oyo‐Ita

Wiysonge

Oringanje³

et al. 2016

Cochrane Database of Systematic Reviews

204

190

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Background Immunisation is a powerful public health strategy for improving child survival, not only by directly combating key diseases that kill children but also by providing a platform for other health services. However, each year millions of children worldwide, mostly from low- and middle-income countries (LMICs), do not receive the full series of vaccines on their national routine immunisation schedule. This is an update of the Cochrane review published in 2011 and focuses on interventions for improving childhood immunisation coverage in LMICs. Objectives To evaluate the effectiveness of intervention strategies to boost and sustain high childhood immunisation coverage in LMICs. Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL) 2016, Issue 4, part of The Cochrane Library . www.cochranelibrary.com, including the Cochrane Effective Practice and Organisation of Care (EPOC) Group Specialised Register (searched 12 May 2016); MEDLINE In-Process and Other Non-Indexed Citations, MEDLINE Daily and MEDLINE 1946 to Present, OvidSP (searched 12 May 2016); CINAHL 1981 to present, EbscoHost (searched 12 May 2016); Embase 1980 to 2014 Week 34, OvidSP (searched 2 September 2014); LILACS, VHL (searched 2 September 2014); Sociological Abstracts 1952 - current, ProQuest (searched 2 September 2014). We did a citation search for all included studies in Science Citation Index and Social Sciences Citation Index, 1975 to present; Emerging Sources Citation Index 2015 to present, ISI Web of Science (searched 2 July 2016). We also searched the two Trials Registries: ICTRP and ClinicalTrials.gov (searched 5 July 2016) Selection criteria Eligible studies were randomised controlled trials (RCT), non-RCTs, controlled before-after studies, and interrupted time series conducted in LMICs involving children aged from birth to four years, caregivers, and healthcare providers. Data collection and analysis We independently screened the search output, reviewed full texts of potentially eligible articles, assessed risk of bias, and extracted data in duplicate; resolving discrepancies by consensus. We then conducted random-effects meta-analyses and used GRADE to assess the certainty of evidence. Main results Fourteen studies (10 cluster RCTs and four individual RCTs) met our inclusion criteria. These were conducted in Georgia (one study), Ghana (one study), Honduras (one study), India (two studies), Mali (one study), Mexico (one study), Nicaragua (one study), Nepal (one study), Pakistan (four studies), and Zimbabwe (one study). One study had an unclear risk of bias, and 13 had high risk of bias. The interventions evaluated in the studies included community-based health education (three studies), facility-based health education (three studies), household incentives (three studies), regular immunisation outreach sessions (one stud...

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Section: Introductionmentioning

confidence: 99%

Interventions for improving coverage of childhood immunisation in low- and middle-income countries

Oyo‐Ita

Wiysonge

Oringanje³

et al. 2016

Cochrane Database of Systematic Reviews

204

190

View full text Add to dashboard Cite

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“…Table 1 shows the performance of yellow fever case-based surveillance in Cameroon. Since 2003 yellow fever surveillance in the country has been fully integrated with surveillance activities for acute flaccid paralysis and measles [ 16 , 18 , 24 ]. The surveillance of all three vaccine-preventable diseases share the same personnel and infrastructure at all levels of Cameroon's health care system, including personnel for reporting and investigation of suspected cases, specimen transport, and data management systems.…”

Section: Resultsmentioning

confidence: 99%

“…Opportunities for improving yellow fever control in Cameroon include the recently formed Yellow Fever Initiative [ 10 ] and the high-level political commitment to the control of vaccine-preventable diseases in the country [ 16 , 19 ]. The Yellow Fever Initiative will assist 12 priority countries in West Africa, including Cameroon, to conduct mass preventive vaccination campaigns targeting 48 million people between 2007 and 2010.…”

Section: Discussionmentioning

confidence: 99%

“…In September-December 1990 during one epidemic in the Far North Province of the country, 182 cases (with 69% case-fatality rate) were reported [ 13 ], but it is estimated that up to 20,000 cases may have occurred during that epidemic [ 15 ]. Building upon experience gained in conducting high-quality polio eradication and measles elimination activities [ 16 - 19 ], in 2002 Cameroon developed a five-year (2003–2007) strategic plan for yellow fever control. In this report, we present progress and challenges of implementing the plan during its first four years of existence.…”

Section: Introductionmentioning

confidence: 99%

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Yellow fever control in Cameroon: Where are we now and where are we going?

Wiysonge

Nomo

Mawo

et al. 2008

BMC Med

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Background: Cameroon is one of 12 African countries that bear most of the global burden of yellow fever. In 2002 the country developed a five-year strategic plan for yellow fever control, which included strategies for prevention as well as rapid detection and response to outbreaks when they occur. We have used data collected by the national Expanded Programme on Immunisation to assess the progress made and challenges faced during the first four years of implementing the plan.

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“…Only about 10-15% of poliomyelitis cases are bulbar. The mortality rates of spinal and bulbar poliomyelitis are approximately 5% and 50% respectively [50][51][52].…”

Section: Poliomyelitismentioning

confidence: 99%

The Efficacy of Viral Capsid Inhibitors in Human Enterovirus Infection and Associated Diseases

Li¹,

Wang²,

Shih³

et al. 2007

CMC

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Enteroviruses are members of picornavirus family which causes diverse and severe diseases in humans and animals. Clinical manifestations of enterovirus infections include fever, hand, foot, and mouth disease, and herpangina. Enteroviruses also cause potentially severe and life-threatening infections such as meningitis, encephalitis, myocarditis, polio-like syndrome, and neonatal sepsis. With the emergence of enterovirus all over the world as the major causative agent of HFMD fatalities in recent years and in the absence of any effective anti-enteroviral therapy, there is clearly a need to find a specific antiviral therapy. Steps such as viral attachment, uncoating, viral RNA replication, and protein synthesis in the replication cycle can serve as potential targets for antiviral agents. Agents targeted at viral protein 1 (VP1), a relatively conserved capsid structure mediating viral adsorption and uncoating process, is of great potential to be anti-enterovirus drugs. Recently, considerable efforts have been made in the development of antiviral compounds targeting the capsid protein of enterovirus. This review summarizes the development of small molecules targeting enteroviral capsid protein as effective antiviral therapy.

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Eradication of poliomyelitis

Cited by 9 publications

References 1 publication

Interventions for improving coverage of childhood immunisation in low- and middle-income countries

Interventions for improving coverage of childhood immunisation in low- and middle-income countries

Yellow fever control in Cameroon: Where are we now and where are we going?

The Efficacy of Viral Capsid Inhibitors in Human Enterovirus Infection and Associated Diseases

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