Eradication of Helicobacter pylori with pantoprazole and two antibiotics: a comparison of two short‐term regimens

Abstract

Since the discovery of Helicobacter pylori in the early 1980s, its role as a major pathogenic factor in peptic ulcer disease has been well established. Therapeutic regimens aiming to eradicate the bacterium have been shown to be highly effective and are strongly recommended in the treatment of patients with peptic ulcer disease.1 With classic bismuth salt based triple therapy, combining bismuth with two antibiotics, poor compliance is often observed resulting from a high incidence of side-effects. 2 In search for therapeutic approaches leading to fewer side-effects and compliance problems, regimens combining antibiotics with proton pump inhibitors have been under investigation. The latter are not only used to relieve symptoms but also to provide an optimal environment for the action of the antibiotics. 3As reported by several authors, a short-term therapy with omeprazole in combination with clarithromycin and either amoxycillin or metronidazole can achieve eradication rates of above 90%. 4±6 These regimens were

Eradication of Helicobacter pylori by 7‐Day Triple‐Therapy Regimens Combining Pantoprazole with Clarithromycin, Metronidazole, or Amoxicillin in Patients with Peptic Ulcer Disease: Results of Two Double‐Blind, Randomized Studies

“…PCM was also significantly superior to CM. These results are consistent with published reports of triple therapy with a PPI plus clarithromycin and metronidazole or clarithromycin plus amoxicillin [48,52,54,60,61,85–102].…”

Primary resistance to antibiotics and its clinical impact on the efficacy of Helicobacter pylori lansoprazole‐based triple therapies

“… 5 The current recommended eradication therapies comprise a proton pump inhibitor, clarithromycin and amoxicillin or metronidazole, twice daily for a 1‐week period 6–8 . By use of these treatments, > 90% cure rates are reported in some studies 9–12 . However, an eradication failure ranging from 20% to 40% is found, mainly because of antimicrobial resistance 13–17 …”

4-day triple therapy with rabeprazole, amoxicillin and clarithromycin in the eradication of Helicobacter pylori in patients with peptic ulcer disease - - A pilot study - -

“…To evaluate H. pylori treatment by the C 13 -urea breath test seems fair and appropriate while this noninvasive test is a highly accurate method for the short-term follow-up after eradication therapy [24,25].…”