Eradication of Helicobacter pylori by 7‐Day Triple‐Therapy Regimens Combining Pantoprazole with Clarithromycin, Metronidazole, or Amoxicillin in Patients with Peptic Ulcer Disease: Results of Two Double‐Blind, Randomized Studies

Abstract

PCM had the highest overall eradication rate in these two studies examining 7-day treatment regimens. All regimens were safe and well tolerated.

The efficacy, safety and tolerability of pantoprazole-based one-week triple therapy in H. pylori eradication and duodenal ulcer healing

“…The presence of clarithromycin resistance is predictive of treatment failure and it is more predictive than metronidazole resistance 31 . To overcome this issue, extending the duration of therapy (10 days to 2 weeks) and highly specific susceptibility testing before starting eradication treatment may be considered 29 . Based on these data, we conclude that the H. pylori eradication rate achieved in this study is satisfactory considering the increase observed in antibiotic resistance.…”

Helicobacter pyloritherapy: a paradigm shift

“…Intention to treat cure rates and standard deviation reported for the clinical trials done to obtain US Food and Drug Administration approval for PPI, clarithromycin, amoxicillin triple in the United States [26-29]. …”

Sequential therapy for Helicobacter pylori eradication

“…It has been observed in recent studies performed with triple combination in western countries that the eradication success rates have been declining over the years. Bochenek et al (9) achieved a 57%-73% success rate in a 7-day study, whereas Vakil et al (6) achieved a 67%-79% eradication success rate in a 10-day treatment study. Our country is similar to the developing countries in terms of H. pylori prevalence.…”