Equilibrium and release properties of hyaluronic acid–drug complexes

Battistini, F. D.; Olivera, Marı́a Eugenia; Manzo, Rubén H.

doi:10.1016/j.ejps.2013.04.023

Cited by 21 publications

(27 citation statements)

References 35 publications

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“…Thanks to the better adhesion and distribution of the nanoparticles and the formation of a well-structured system, the release of MEL was controlled. This controlled release was enhanced by the HA-PVA system (Battistini et al, 2013). The PVA-coated particles played a role in the release of the drug, because the synthetic polymers reduced the rate of degradation of the natural polymers and prevented their rapid dissolution in the biological fluids (Ding et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

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Study of sodium hyaluronate-based intranasal formulations containing micro- or nanosized meloxicam particles

Bartos

Ambrus

Sipos

et al. 2015

International Journal of Pharmaceutics

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Section: Discussionmentioning

confidence: 99%

“…This can be explained by the interaction between the HA and MEL which resulted in complex between the carboxylic groups in HA and the protonable groups in MEL (Battistini et al, 2013).…”

Section: Characterization Of the Nasal Spraysmentioning

confidence: 98%

Study of sodium hyaluronate-based intranasal formulations containing micro- or nanosized meloxicam particles

Bartos

Ambrus

Sipos

et al. 2015

International Journal of Pharmaceutics

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“…Similar studies reported that ionic interactions between bulk of carbohydrate polymers and small molecules improve drug affinity and long‐term release. In this regard, hyaluronic acid and alginate carriers have been applied. We showed that surface modification of PHEMA polymers using a highly charged polysaccharide like chitosan could improve ascorbic acid loading (most presumably though ionic interactions between opposite charges) and increase sustained release up to 10 days.…”

Section: Discussionmentioning

confidence: 99%

Chitosan surface modified hydrogel as a therapeutic contact lens

Ashtiani

Zandi

Shokrollahi

et al. 2019

Polymers for Advanced Techs

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Therapeutic contact lenses have attracted significant attention during the last decades. In this study, we used chitosan‐conjugated poly(2‐hydroxyethyl methacrylate) (PHEMA) for contact lens application. We aimed to increase affinity of anionic drugs, which are used in treatment of eye diseases. In this regard, we evaluated delivery of the small molecule anionic drug, ascorbic acid from the chitosan‐conjugated PHEMA. Chitosan immobilization improves drug loading efficiency and induces sustained release of ascorbic acid. The chitosan modified hydrogel also reduces the biofouling of tear fluid components. Our results showed that surface modification by chitosan inhibits protein and bacterial deposition on the contact lens. Protein absorption analysis revealed that neat PHEMA adsorbed tear proteins at a density of 28.4 ± 4.4 μg/cm2, whereas the chitosan‐conjugated hydrogel adsorbed tear proteins at a density of 18.5 ± 1.8 μg/cm2. Moreover, the neat PHEMA bacterial adhesion had a mean CFU value of 273 ± 27. However, a significant decrease in the number of bacterial colonies was observed in the chitosan group with a CFU value of 9 ± 6.

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“…The second drug was BSA, a well-known and highly characterised molecule, which represented a model drug with a higher molecular weight (Mw of 64,000 g/mol) than lidocaine. With a pKa of 7.9, under physiological conditions [23], lidocaine is ionically linked to HA, which is polyanionic at this pH [24]. Therefore, drug release is controlled both by the electrostatic forces and visco-elastic properties of the gel [25,26].…”

Section: Discussionmentioning

confidence: 99%

Influence of the Macro- and/or Microstructure of Cross-Linked Hyaluronic Acid Hydrogels on the Release of Two Model Drugs

Mondon¹,

Dadras²

2016

J Glycobiol

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Injectable hyaluronic acid (HA) hydrogels, crosslinked with 1,4-butanediol diglycidyl ether (BDDE), are widely used in aesthetic medicine. Due to their high clinical tolerance, HA hydrogels are thought to be applicable as injectable drug delivery systems. Here, HA matrix structures of BDDE-crosslinked HA hydrogels were analysed, and the effects of the structures on the release of two model drugs were assessed. Seven crosslinked HA hydrogels were observed by optical microscopy and cryo scanning electron microscopy (cryo-SEM). We observed three specific matrix macrostructures under optical microscopy: two had a "spider web"-like structure, three had a particulate structure, and two had an intermediate structure. These differences were less evident under cryo-SEM, where all hydrogels exhibited fibrous microstructures of different homogeneity levels, with pore sizes between 0.5 and 18 μm. Three cross-linked HA hydrogels with different macrostructures were loaded with bovine serum albumin (BSA) and lidocaine to assess their capacities to release drug over 4 days. No differences in drug release were observed between gels, and BSA was released for up to 4 days, which was four times longer than lidocaine. Thus, BDDEcrosslinked HA hydrogels could be applied as an injectable drug delivery system, particularly for the delivery of high-molecular-weight molecules.

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Equilibrium and release properties of hyaluronic acid–drug complexes

Cited by 21 publications

References 35 publications

Study of sodium hyaluronate-based intranasal formulations containing micro- or nanosized meloxicam particles

Study of sodium hyaluronate-based intranasal formulations containing micro- or nanosized meloxicam particles

Chitosan surface modified hydrogel as a therapeutic contact lens

Influence of the Macro- and/or Microstructure of Cross-Linked Hyaluronic Acid Hydrogels on the Release of Two Model Drugs

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