Chitosan surface modified hydrogel as a therapeutic contact lens

Ashtiani, Mohammad Kazemi; Zandi, Mojgan; Shokrollahi, Parvin; Ehsani, Morteza; Baharvand, Hossein

doi:10.1002/pat.4810

Cited by 21 publications

(6 citation statements)

References 38 publications

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“…Ulu et al created an antibacterial contact lens for the treatment of ocular infections using PHEMA hydrogel that was loaded with the antibacterial chemical boric acid [59]. A hydrogel based on PHEMA was created by Ashtiani et al as a therapeutic contact lens for the administration of small-molecule medications [60]. Chitosan was used to alter the hydrogel in their investigation.…”

Section: Methodsmentioning

confidence: 99%

Smart Contact Lenses—A Step towards Non-Invasive Continuous Eye Health Monitoring

Kazanskiy,

Khonina,

Butt

2023

Biosensors

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According to the age-old adage, while eyes are often considered the gateway to the soul, they might also provide insights into a more pragmatic aspect of our health: blood sugar levels. This potential breakthrough could be realized through the development of smart contact lenses (SCLs). Although contact lenses were first developed for eyesight correction, new uses have recently become available. In the near future, it might be possible to monitor a variety of ocular and systemic disorders using contact lens sensors. Within the realm of glaucoma, SCLs present a novel prospect, offering a potentially superior avenue compared to traditional management techniques. These lenses introduce the possibility of non-invasive and continuous monitoring of intraocular pressure (IOP) while also enabling the personalized administration of medication as and when needed. This convergence holds great promise for advancing glaucoma care. In this review, recent developments in SCLs, including their potential applications, such as IOP and glucose monitoring, are briefly discussed.

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Section: Methodsmentioning

confidence: 99%

Smart Contact Lenses—A Step towards Non-Invasive Continuous Eye Health Monitoring

Kazanskiy,

Khonina,

Butt

2023

Biosensors

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“…Chitosan modification induced continuous ascorbic acid release and increased drug loading efficiency. In addition, surface modification with chitosan has been shown to inhibit protein and bacterial accumulation on the CL [ 81 ]. In another study, they modified PHEMA based hydrogels that are widely used in biomedical applications.…”

Section: Combination Use Of Nanotechnology and Other New Techniques F...mentioning

confidence: 99%

Application of Convergent Science and Technology toward Ocular Disease Treatment

et al. 2023

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Eyes are one of the main critical organs of the body that provide our brain with the most information about the surrounding environment. Disturbance in the activity of this informational organ, resulting from different ocular diseases, could affect the quality of life, so finding appropriate methods for treating ocular disease has attracted lots of attention. This is especially due to the ineffectiveness of the conventional therapeutic method to deliver drugs into the interior parts of the eye, and the also presence of barriers such as tear film, blood-ocular, and blood-retina barriers. Recently, some novel techniques, such as different types of contact lenses, micro and nanoneedles and in situ gels, have been introduced which can overcome the previously mentioned barriers. These novel techniques could enhance the bioavailability of therapeutic components inside the eyes, deliver them to the posterior side of the eyes, release them in a controlled manner, and reduce the side effects of previous methods (such as eye drops). Accordingly, this review paper aims to summarize some of the evidence on the effectiveness of these new techniques for treating ocular disease, their preclinical and clinical progression, current limitations, and future perspectives.

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“…[ 96 ] The hydrogel also showed two‐step release behavior, a burst release of nepafenac due to desorption and diffusion of drug from the surface, followed with a slow and sustained release behavior. The potential of CTS hydrogels for delivery of various drugs such as Nepafenac, [ 96,97 ] Moxifloxacin and Gentamicin, [ 98 ] 5‐fluorouracil (5FU), [ 99–101 ] Ascorbic acid, [ 102 ] Levofloxacin, [ 103,104 ] Baicalin [ 105 ] and Quercetin [ 106 ] to the defected cornea was also recently confirmed. Table 4 reviews the recent (2010 to 2020) in vitro (Table 4A), in vivo (Table 4B) and cell/drug delivery (Table 4C) investigations and their outcomes on the potential of CTS‐based hydrogels for cornea tissue engineering.…”

Section: Hydrogels For Corneal Tissue Engineering and Cells/drug Deliverymentioning

confidence: 99%

Hydrogels as Emerging Materials for Cornea Wound Healing

Khosravimelal

Mobaraki

Eftekhari

et al. 2021

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According to a World Health Organization (WHO) estimation, over 10 million patients suffer from visual impairments and vision loss annually due to corneal diseases or injuries. [6,8] The corneal response to injury involves a highly complicated cascade of events that comprises cell adhesion, migration, differentiation, proliferation, death, and extracellular matrix (ECM) remodeling mediated by immunomodulators and growth factors. [9,10] Conserving the corneal transparency is critical for visual perception. Therefore, any destruction that affects its integrity caused by diseases or trauma like bullous keratopathy, keratoconus, and scarring can lead to blurred eyesight and eventually blindness. [4,11,12] Among all the therapeutic modalities that contributed to corneal irreversible damages including drug and gene therapy and surgical techniques, the keratoplasty with a human donor has offered the best clinical outcome with an 80% rate of success. [2,11,13] However, despite a high success rate, increasing demands for donor tissue and graft rejection due to severe immune response of the hosts are considered as the major reasons for developing an alternative to this procedure. [6,11,13,14] Cell therapies in combination with 3D biocompatible scaffolds have the great potential to replace donor tissue for transplantation or improve wound healing. [15] The potential of cell therapy in corneal wound healing has previously been discussed. [16] 3D scaffolds can mimic the composition and structure of the cornea and

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Chitosan surface modified hydrogel as a therapeutic contact lens

Cited by 21 publications

References 38 publications

Smart Contact Lenses—A Step towards Non-Invasive Continuous Eye Health Monitoring

Smart Contact Lenses—A Step towards Non-Invasive Continuous Eye Health Monitoring

Application of Convergent Science and Technology toward Ocular Disease Treatment

Hydrogels as Emerging Materials for Cornea Wound Healing

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