2021
DOI: 10.1002/smll.202006335
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Hydrogels as Emerging Materials for Cornea Wound Healing

Abstract: According to a World Health Organization (WHO) estimation, over 10 million patients suffer from visual impairments and vision loss annually due to corneal diseases or injuries. [6,8] The corneal response to injury involves a highly complicated cascade of events that comprises cell adhesion, migration, differentiation, proliferation, death, and extracellular matrix (ECM) remodeling mediated by immunomodulators and growth factors. [9,10] Conserving the corneal transparency is critical for visual perception. Ther… Show more

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Cited by 64 publications
(39 citation statements)
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References 239 publications
(303 reference statements)
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“…In general, these methods make use of different types of biomaterials that can be prepared in the laboratory and subsequently seeded with living cells to generate a tissue substitute [16,17]. In the case of the cornea, several models of bioartificial corneas have been developed [18,19], and some of these models have been clinically evaluated [20][21][22]. Again, these techniques need to be significantly improved to allow the efficient reproduction of the delicate histoarchitecture of these tissues.…”
Section: Introductionmentioning
confidence: 99%
“…In general, these methods make use of different types of biomaterials that can be prepared in the laboratory and subsequently seeded with living cells to generate a tissue substitute [16,17]. In the case of the cornea, several models of bioartificial corneas have been developed [18,19], and some of these models have been clinically evaluated [20][21][22]. Again, these techniques need to be significantly improved to allow the efficient reproduction of the delicate histoarchitecture of these tissues.…”
Section: Introductionmentioning
confidence: 99%
“…Hydrogel is a kind of biological material with unique porous structures that can swell in water or biological liquids. Based on its excellent properties, hydrogel has been utilized in drug release during chemoimmunotherapy [ 10 ], tissue engineering [ 11 ], wound dressing [ 12 ], and environmental engineering [ 13 ]. In immunotherapy, the hydrogel network allows the controlled and slow release of therapeutic drugs, nucleic acids, peptides, and therapeutic immune cell culture [ 10 , 14 , 15 ].…”
Section: Hydrogelsmentioning
confidence: 99%
“…To enhance the ocular retention of ophthalmic drugs, various strategies including viscous polymer solutions, adhesive microparticles [ 5 , [9] , [10] , [11] , [12] , [13] ], and hydrogels [ [14] , [15] , [16] ] have been proposed. Among them, hydrogels attracted the most attentions as increasing retention time on ocular surface, high moisturizing, and good compatibility [ [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] ], and the retention time can be extended by almost three times when the formulation was changed from solution to hydrogel [ 14 , 22 ]. Traditional ophthalmic gel is prepared by encapsulation of antibiotic drugs via viscous polymer matrix such as Carbomer [ 26 ], or thermo-sensitive polymers such as Pluronic F127 [ 27 ].…”
Section: Introductionmentioning
confidence: 99%