Equilibria of complexes in the aqueous cobalt(II)–N-(2-hydroxybenzyl)phenylalanine system and their biological activity compared to analogous Schiff base structures

Woźniczka, Magdalena; Świątek, Mirosława; Sutradhar, Manas; Gądek-Sobczyńska, Joanna; Chmiela, Magdalena; Gonciarz, Weronika; Pasternak, Beata; Pająk, Marek

doi:10.1016/j.csbj.2023.01.035

Cited by 7 publications

(2 citation statements)

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“…The typical crystallite size of the sample (in nm) is predicted using Scherrer's relation 57,58 = D k cos hkl (5) Here, the "k" value of the shape constant is 0.95 (organic compounds), λ is the X-ray wavelength (λ CuKα is 1.5406 Å), β hkl is the full-width at half maxima (FWHM) of diffraction planes/peaks, and θ is the angle of diffraction. The value of D is found to be 21.40 nm.…”

Section: X-ray Diffraction (Xrd)mentioning

confidence: 99%

“…Schiff bases are nitrogen analogs of aldehydes and ketones, with imine or azomethine groups replacing the carbonyl group (CO). Schiff bases are used in closure, cycloaddition, and replacement to synthesize several beneficial compounds for industry and human health. − They are also analgesics, anti-inflammatory agents, allergy inhibitors, radical scavengers, anticancer agents, antibacterial agents, antidiabetic agents, and antioxidants. − Due to their biological uses, simplicity of synthesis, chelating properties, and stability, Schiff base compounds are an important and extensively studied class. − …”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Spectral Characterization, Thermal Investigation, Computational Studies, Molecular Docking, and In Vitro Biological Activities of a New Schiff Base Derived from 2-Chloro Benzaldehyde and 3,3′-Dimethyl-[1,1′-biphenyl]-4,4′-diamine

Thakor,

Patel,

Giri

et al. 2023

ACS Omega

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The current research involves the synthesis of a new Schiff base through the reaction between 2-chlorobenzaldehyde and 3,3′-dimethyl-[1,1′-biphenyl]-4,4′-diamine by using a natural acid catalyst and a synthesized compound physicochemically characterized by X-ray diffraction, Fourier transform infrared spectroscopy, 1H- and 13C-nuclear magnetic resonance, and liquid chromatography–mass spectrometry. Thermal studies were conducted using thermogravimetric, differential thermal analysis, and differential thermogravimetric curves. These curves were obtained in an inert nitrogen environment from ambient temperature to 1263 K using heating rates of 10, 15, and 20 K·min–1. Using thermocurve data, model-free isoconversional techniques such as Kissinger–Akahira–Sunose, Flynn–Wall–Ozawa, and Friedman are used to determine kinetic parameters. These parameters include activation energy, phonon frequency factor, activation enthalpy, activation entropy, and Gibb’s free energy change. All of the results have been thoroughly investigated. The molecule’s anti-inflammatory and antidiabetic properties were also examined. To learn more about the potential of the Schiff base and how successfully it can suppress the amylase enzyme, a molecular docking experiment was also conducted. For in silico research, the Swiss Absorption, Distribution, Metabolism, Excretion, and Toxicity algorithms were used to calculate the theoretical pharmacokinetic properties, oral bioavailability, toxic effects, and biological activities of the synthesized molecule. Moreover, the cytotoxicity tests against a human lung cancer cell line (A549) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay demonstrated that the synthesized Schiff base exhibited significant anticancer properties.

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Section: X-ray Diffraction (Xrd)mentioning

confidence: 99%