Epithelioma Adenoides Cysticum and Solitary Trichoepithelioma

Gray, Howard R.

doi:10.1001/archderm.1963.01590130108018

Cited by 134 publications

(96 citation statements)

References 22 publications

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“…10 Trichoepithelioma (TE) is a benign, cutaneous mesenchymal tumor originating from germ layer of hair follicle. [11][12][13] Trichoblastoma (TB) is extremely rare benign tumors located deep dermis and subcutis. 14 It is frequently seen on head and neck 3,15 and mostly sized less than 1 cm in diameter.…”

Section: Introductionmentioning

confidence: 99%

Histopathological Characteristics may not be Useful in the Differential Diagnosis Between Basal Cell Carcinoma and Benign Tumors of Cutaneous Appandages Originating from Hair Follicle

Şengül¹

2011

UHOD

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Differential diagnosis between benign tumors of cutaneous appandages originating from hair follicle (BTCOHF) (trichoadenoma [TA], trichofolliculoma [TF], trichoepithelioma [TE] and trichoblastoma [TB]) and basal cell carcinoma (BCC) have been tedious for the pathologists, especially in the presence of small specimens to date. Thirty cases of BTCOHF and 30 cases of BCC were retrieved from the archives, deposited from 2004 to 2008. Age, sex, localisation and histopathological characters such as ulceration, pigmentation, inflammation, and cyst formation were comparatively evaluated between both groups and each subgroups. No significant diference was detetected between two groups in the rate of the age, sex and the histopathology. Besides, histopathological characters were not significant for the subgroups of BCC. However, ulceration was observed in TE (Of 21 cases 5, [23.8%]) and TB (All the 5 cases, [100%]), but not in TA and TF which are the subgroups of BTCOHF and the difference was significant (p= 0,005). But, pigmentation, inflammation and cyst formation were not significant among the subgroups of both groups. We can conclude that BCC and BTCOHF may not be discriminated concerning age, sex and histopathological characters including ulceration, pigmentation, inflammation, and cyst formation. Secondly, one may not make the differential diagnosis easily even between the subgroups of each group via evaluating the histopathological characters, so that might create some life-threatening unwelcome outcomes. Keywords: Basal cell carcinoma, Pigmentation, Inflammation, Histopathology ÖZET Histopatolojik karakterler Bazal Hücreli Karsinoma ile K›l Follikülünden Köken Alan Benign Deri Eki Tümörlerinin Ay›r›c› Tan›s›nda Yararl› OlamayabilirTrikoadenoma, trikofolliküloma, trikoepitelyoma ve trikoblastoman›n bazal hücreli karsinomadan ay›r›c› tan›s›, bugüne kadar özellikle küçük spesimenlerde patologlar için can s›k›c› ve usand›r›c› olmaya devam edegelmifltir. Otuz k›l follikülünden köken alan benign deri eki tümörleri olgusu ve 30 bazal hücreli karsinoma olgusu, 2004 -2008 y›llar› aras›nda depoland›¤› arflivden yeniden edinildi. Yafl, cinsiyet, lokalizasyon ve ülserasyon, pigmentasyon, inflamasyon ve kist formasyonu gibi histopatolojik karekterler her iki grup ve her subgrup aras›nda karfl›laflt›rmal› olarak de¤erlendirildi. Yafl, cinsiyet, lokalizasyon ve histopatoloji aç›s›ndan iki grup aras›nda anlaml› fark saptanmad›. Ayr›ca, histopatolojik karekterler bazal hücreli karsinoman›n subgruplar› için anlaml› de¤ildi. Bununla birlikte; ülse-rasyon, k›l follikülünden köken alan benign deri eki tümörlerinin subgruplar› olan trikoepitelyoma (21 olgunun 5'inde [%23.8]) ve trikoblastomada (5 olgunun tümünde [%100]) izlendi, ancak trikoadenoma ve trikofollikülomada izlenmedi ve bu fark anlaml› bulundu (p= 0.005). Pigmentasyon, inflamasyon ve kist formasyonu her iki grubun subgruplar› aras›nda anlaml› de¤ildi.

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Section: Introductionmentioning

confidence: 99%

Histopathological Characteristics may not be Useful in the Differential Diagnosis Between Basal Cell Carcinoma and Benign Tumors of Cutaneous Appandages Originating from Hair Follicle

Şengül¹

2011

UHOD

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“…The multiple tumors have an autosomal dominant pattern of inheritance, with a greater female penetrance. Gray and Helwig [4] noted that over half of 36 patients reviewed had a family history of the disease. There is no racial predilection or any association with other organ system abnormalities except an occasional association with cylindroma and syringoma [4-91.…”

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confidence: 99%

“…The general belief is that these tumors remain benign. In one review, none of the 192 lesions had micro scopic features suggestive of malignant transformation [4].…”

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confidence: 99%

“…absence of inflammatory cellular infiltrate and sharp demarcation are all features helpful in distinguishing tri choepitheliomas from basal cell carcinomas. Despite this, only half of the lesions are initially correctly diagnosed; most commonly, they arc misdiagnosed as keratotic basal cell carcinoma [4], Despite being benign, these tumors pose cosmetic and, occasionally, functional problems when they involve the ear canals or eyelids. Surgery is the treatment of choice for solitary lesions and has been successful.…”

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confidence: 99%

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Trichoepithelioma 100 Years Later: A Case Report Supporting the Use of Radiotherapy

Aygün

Blum²

1993

Dermatology

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Trichoepitheliomas are rare skin tumors which can cause significant cosmetic and functional impairment when they occur in the head and neck area. Multiple methods of treatment including plastic surgery, dermabrasion, cryosurgery and laser surgery have been reported in the literature. A 32-year-old male with multiple coalesced lesions in his ear canals was treated with radiation therapy after he failed more conventional methods of treatment. He is free of tumor in the radiated area 17.5 months after treatment with significant functional improvement. Various aspects of this tumor were reviewed. More data are still needed to define the proper place for radiation in the management of this disease.

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“…Desmoplastic changes have been reported to occur following inflammation [7], other types of tissue injury and neoplasm [6]. Inflammation is commonly associated with the multiple familial variant of trichoepithelioma, particularly the ones caused by CYLD gene mutations [8,9].…”

Section: Discussionmentioning

confidence: 99%

Giant solitary trichoepithelioma with desmoplasia on histopathology: An unusual finding

Chowdhry¹,

Gupta²,

Verma³

et al. 2016

Our Dermatol Online

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Epithelioma Adenoides Cysticum and Solitary Trichoepithelioma

Cited by 134 publications

References 22 publications

Histopathological Characteristics may not be Useful in the Differential Diagnosis Between Basal Cell Carcinoma and Benign Tumors of Cutaneous Appandages Originating from Hair Follicle

Histopathological Characteristics may not be Useful in the Differential Diagnosis Between Basal Cell Carcinoma and Benign Tumors of Cutaneous Appandages Originating from Hair Follicle

Trichoepithelioma 100 Years Later: A Case Report Supporting the Use of Radiotherapy

Giant solitary trichoepithelioma with desmoplasia on histopathology: An unusual finding

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