Epithelioid sarcoma of the penis: Report of an unusual case and review of the literature

Epithelioid sarcoma of the penis—a rare differential diagnosis of Peyronie's disease

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Typically, patients present with a Peyronie's plaque-like induration of the penis, local pain, with or without penile curvature, sometimes with dysuria in cases of urethral narrowing and exulceration (Table 1). [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] It mainly affects younger men under 40 years. [1][2][3][5][6][7][8][9][10][11][12][13][14][15]…”

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] It mainly affects younger men under 40 years. [1][2][3][5][6][7][8][9][10][11][12][13][14][15][16][17][18] It is a malignant soft tissue tumor of unclear cell type and origin. Morphologically, epithelioid sarcoma is characterized by a mixture of epithelioid and spindle cells, that are often arranged in nodular aggregates around a central necrosis.…”

“…20 Since its first description, epithelioid sarcoma has been found to occur in the extremities, the trunk, the scalp, the vulva, and the penis, respectively. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] The recommended treatment is a wide resection with adequate margins, lymph node dissection, and optional adjuvant radiotherapy. 20 The best therapeutic results (Table 1) have been achieved after total or subtotal penectomy, with or without adjuvant radiation therapy.…”

“…20 The best therapeutic results (Table 1) have been achieved after total or subtotal penectomy, with or without adjuvant radiation therapy. 4,7,9,10,12,13,17,18 Prognostic data are unprecise concerning the very short follow-ups of up to 24 months, [1][2][3][4][5][6][7]9,10,[12][13][14][15][16][17][18] there have been only two observations up to 8 and 10 years, respectively. 8,11 There is a tendency for a better prognosis after excision, but since the follow-up periods in all cases are too short with regard to the formation of metastases, 8 a real prognostic statement appears to be impossible at present.…”

“…2,9,10,12,[16][17][18] Other misdiagnoses were urethral stricture, 4 infection of the glans penis. 6 In two other cases, penile epithelioid sarcoma was primarily misdiagnosed histologically as granulomatous inflammation or and fibroxanthoma.…”