Epithelioid hemangioendothelioma, an uncommon tumor of the eyelid: A case report

Ennouhi, Mohamed Amine; Guerrouani, Alae; Moussaoui, Ali El

doi:10.1016/j.jormas.2017.10.001

Cited by 3 publications

(5 citation statements)

References 16 publications

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“…EH occurs in superficial or deep soft tissues such as those of the extremities, liver, lungs and bone, and rarely in the orbit and/or eyelids ( 4 , 5 ). Since Tsuji et al ( 6 ) first reported EHE in 2010, to the best of our knowledge, only 4 cases have been reported worldwide ( 6 – 9 ). Combined with the present case, these 5 cases were analyzed in the present literature review.…”

Section: Discussionmentioning

confidence: 99%

“…In the literature review, three cases of EHE underwent surgical resection and no recurrence or metastasis was observed at the 14-44 month follow-up periods (6)(7)(8). Ennouhi et al (9) reported a case of recurrence due to a positive surgical margin twice, but no recurrence or metastasis was found in the 60 months of follow-up after the third surgical resection.…”

Section: Discussionmentioning

confidence: 99%

“…Some cases were clinically diagnosed as hemangioma, chalazion or cysts. Computed tomography and magnetic resonance imaging showed multiple eyelid tumors extending into the orbit without bone tissue involvement in one case ( 9 ). In some patients, other general examinations such as blood routine, liver and kidney function tests, chest radiography and abdominal ultrasound showed no abnormalities.…”

Section: Discussionmentioning

confidence: 99%

“…The overall 5-year survival rate for patients with the neoplasm is 73% (2). Since Tsuji et al (6) first reported EH of the eyelid (EHE) in 2010, four cases have been reported in studies published in English (6)(7)(8)(9). Microscopically, the tumor consists of proliferating epithelioid and fusiform vascular endothelial cells, and the atypia of epithelioid and spindle cells is not obvious.…”

Section: Introductionmentioning

confidence: 99%

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Primary epithelioid hemangioendothelioma of the eyelid: A case report

et al. 2022

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Eyelid epithelioid hemangioendothelioma (EHE) is uncommon. The present study reports the clinical, histopathological and immunohistochemical characteristics of a 10-year-old girl with EHE and reviews the related literature. The patient was admitted with a painless red mass on the left eyelid, which had been present for 6 months. Under the microscope, tumor cells from the surgical specimen were composed of epithelioid cells (70%) and spindle cells (30%). The cytoplasm was eosinophilic, and some areas of the cytoplasm showed signet ring-like or vacuolization changes. The presence of red blood cells could be seen in the luminal part of the primary blood vessel. Immunohistochemical results showed that the tumor cells were positive for CD34 and CD31, and the Ki-67 proliferation index was 3%. As the first resection margin was positive, recurrence occurred 3 months after surgery, Therefore, patients with such tumors should undergo full resections to ensure a negative margin to prevent recurrence.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Primary epithelioid hemangioendothelioma of the eyelid: A case report

et al. 2022

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“…Most EHE patients are asymptomatic at the time of the diagnosis, but as the disease advances, severe burning pain is the most common symptom [3]. Currently, various therapies, including drug treatment [4] [5], interventional therapy [6], radiotherapy [7], and surgical treatment [8] have been described, however, none of these therapies can completely cure this disease, and pain may become more and more refractory [9].…”

Section: Introductionmentioning

confidence: 99%

Application of Ultrahigh Doses of Morphine in Systemic Multiple Epithelioid Hemangioendothelioma without Addiction: A Case Report

Liu¹,

Ma²,

Ning³

et al. 2019

CRCM

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Morphine is a potent opioid which is commonly used for relieving cancer pain with strong analgesic properties. Epithelioid hemangioendothelioma (EHE), a rare vascular tumor that can cause severe chronic pain, is usually diagnosed in a surgical biopsy. We describe ultrahigh doses of morphine used in a case of a 17-year-old male who suffered from severe chest pain with systemic multiple EHE. The total dosage of morphine was as high as 92,530 mg given within 164 days. However, we observed no indications that the patient was addicted.

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Malignant Vascular Tumors of the Head and Neck—Which Type of Therapy Works Best?

Wiegand

Dietz

Wichmann

2021

Cancers

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Malignant vascular tumors of the head and neck are rare neoplasms with variable clinical presentation, wide age distribution, and variable clinical courses. The heterogeneous presentation of angiosarcomas and epithelioid hemangioendothelioma often leads to misdiagnosis and unsuitable treatment. While risk factors for angiosarcomas are previous radiation, chronic lymphedema, and exposure to arsenic, thorium oxide, or vinyl chloride, there are only limited and retrospective data available on prognostic factors in EHE. In both angiosarcomas and EHE, surgery is the mainstay of treatment. There is limited evidence regarding the role of radiotherapy in EHE, although EHE is considered relatively radiosensitive. In angiosarcomas, adjuvant radiotherapy is recommended according to retrospective case series. A standard medical therapy for metastasized malignant vascular tumors is lacking. Chemotherapy, which is effective in angiosarcoma, is mostly ineffective in EHE. Targeted therapy, antiangiogenetic drugs and immunotherapy have been studied as new treatment options. The goal of this review is to summarize the current data regarding malignant vascular tumors along with their diagnosis and management.

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Epithelioid hemangioendothelioma, an uncommon tumor of the eyelid: A case report

Cited by 3 publications

References 16 publications

Primary epithelioid hemangioendothelioma of the eyelid: A case report

Primary epithelioid hemangioendothelioma of the eyelid: A case report

Application of Ultrahigh Doses of Morphine in Systemic Multiple Epithelioid Hemangioendothelioma without Addiction: A Case Report

Malignant Vascular Tumors of the Head and Neck—Which Type of Therapy Works Best?

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