Malignant Vascular Tumors of the Head and Neck—Which Type of Therapy Works Best?

Wiegand, Susanne; Dietz, Andreas; Wichmann, Gunnar

doi:10.3390/cancers13246201

Cited by 8 publications

(5 citation statements)

References 104 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although there was no straightforward explanation, previous literature provided evidence that Pr might lead to significant DNA genetic damage to Sprague-Dawley rats at a certain concentration ( 42 ). As for Th and Y, contrary to our results, previous studies have reported that these elements could cause genetic damage and induce cancer ( 42 – 45 ). However, as radiometal carriers, Th and Y exerted a beneficial action against the carcinoma of head and neck in clinical practice ( 46 , 47 ).…”

Section: Discussioncontrasting

confidence: 99%

Combined Exposure to 33 Trace Elements and Associations With the Risk of Oral Cancer: A Large-Scale Case-Control Study

Wang

Wang²,

Cao³

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

BackgroundTrace elements exist widely in the natural environment and mostly enter the human body through drinking water or various types of food, which has raised increasing health concerns. Exposure to a single or a few trace elements has been previously reported to be associated with oral cancer risk, but studies on other elements and combined effects are limited. This study aimed to comprehensively evaluate the independent and joint effects of 33 trace elements on oral cancer risk.MethodsThe concentrations of 33 trace elements from the serum samples of 463 cases and 1,343 controls were measured using inductively coupled plasma mass spectrometry (ICP-MS). Propensity score matching was used to minimize the impact of potential confounders. Conditional logistic regression was utilized to evaluate the association of each element individually with oral cancer risk. Quantile g-computation and Bayesian kernel machine regression (BKMR) models were used to assess the joint effect of the overall element mixture and interactions.ResultsIn single-element models, essential elements (Cu, Se, Zn, Sr, and Cr) and non-essential elements (As, Li, Th, Ce, Ti, and Sc) showed significant association with oral cancer risk. In multiple-element models, a quartile increase in overall non-essential elements was observed for a significant inverse association with oral cancer risk (β = −3.36, 95% CI: −4.22 to −2.51). The BKMR analysis revealed a potential beneficial joint effect of essential metals on the risk of oral cancer. Among these, higher levels of serum Zn and V exhibited an adverse effect, while serum Sr, Se, and Cu displayed favorable effects when all other essential elements were fixed at 25th or 50th percentiles. Of note, Se performed complex interactions among essential metals. As for non-essential elements, there were greater effect estimates for serum Th, Li, and Y when all other elements were held at the 75th percentile.ConclusionThis study provides supportive evidence that the overall mixture effect of essential and non-essential elements might be associated with oral cancer risk, especially for serum Zn, V, Cu, Sr, Se, Th, Li, and Y. Extensive prospective studies and other experiments are warranted to confirm our findings.

show abstract

Section: Discussioncontrasting

confidence: 99%

Combined Exposure to 33 Trace Elements and Associations With the Risk of Oral Cancer: A Large-Scale Case-Control Study

Wang

Wang²,

Cao³

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

show abstract

“…Primary angiosarcoma: Clear surgical margins correlate with better outcomes [ 65 ] and positive margins to poorer prognosis [ 66 ], which is why positive margins should always be managed by re-resection. Surgery can be challenging due to the close relation to anatomically important structures in the head and neck region [ 67 ]; however, pAS is treated by radical surgery—followed by RT [ 38 , 68 ].…”

Section: Treatment Algorithms and Strategiesmentioning

confidence: 99%

A Multidisciplinary Approach to Complex Dermal Sarcomas Ensures an Optimal Clinical Outcome

Trøstrup

Bigdeli

Krogerus

et al. 2022

Cancers

View full text Add to dashboard Cite

Primary dermal sarcomas (PDS) belong to a highly clinically, genetically and pathologically heterogeneous group of rare malignant mesenchymal tumours primarily involving the dermis or the subcutaneous tissue. The tumours are classified according to the mesenchymal tissue from which they originate: dermal connective tissue, smooth muscle or vessels. Clinically, PDS may mimic benign soft tissue lesions such as dermatofibromas, hypertrophic scarring, etc. This may cause substantial diagnostic delay. As a group, PDS most commonly comprises the following clinicopathological forms of dermal sarcomas: dermatofibrosarcoma protuberans (DFSP), atypical fibroxanthoma (AFX), dermal undifferentiated pleomorphic sarcoma (DUPS), leiomyosarcoma (LMS), and vascular sarcomas (Kaposi’s sarcoma, primary angiosarcoma, and radiation-induced angiosarcoma). This clinical entity has a broad spectrum regarding malignant potential; however, local aggressive behaviour in some forms causes surgical challenges. Preoperative, individualised surgical planning with complete free margins is pivotal along with a multidisciplinary approach and collaboration across highly specialised surgical and medical specialties. The present review gives a structured overview of the most common forms of dermal sarcomas including surgical recommendations and examples for advanced reconstructions as well as the current adjunctive medical treatment strategies. Optimal aesthetic and functional outcomes with low recurrence rates can be achieved by using a multidisciplinary approach to complex dermal sarcomas. In cases of extended local tumour invasion in dermal sarcomas, advanced reconstructive techniques can be applied, and the interdisciplinary microsurgeon should be an integral part of the sarcoma board.

show abstract

“…Mit der Kombination aus Chemo-und Lokaltherapie werden sehr gute, ereignisfreie Überlebensraten von Patient*innen mit primär lokalisierten Rhabdomyosarkomen erreicht [20,21]. Eine primäre Tumorresektion wird heutzutage nur noch dann angestrebt, wenn eine "onkologische radikale Tumorresektion ohne Verstümmelung zumindest sehr wahrscheinlich erscheint".…”

Section: Orbita Und Gesichtsschädelunclassified

“…Angiosarkome der Orbita-und Gesichtsregion (aber auch insgesamt im Kopf-Hals-Bereich) haben bekanntermaßen eine extrem schlechte Prognose, auch im Vergleich zu den anderen Weichgewebesarkomen [21]. In einer retrospektiven Analyse von Willers et al [22] liegen Überlebensrate, lokoregionale Kontrolle und Freiheit von Fernmetastasen bei 31 %, 24 % und 42 % nach 5 Jahren (im Vergleich die anderen Weichgewebesarkome: 74 %, 69 %, 83 %).…”

Section: Angiosarkomeunclassified

Weichgewebesarkome im Kopf-Hals-Bereich: Aktuelle Therapie – Teil 2

Dietz

Lethaus²,

Pirlich³

et al. 2022

Laryngorhinootologie

Self Cite

View full text Add to dashboard Cite

Malignant Vascular Tumors of the Head and Neck—Which Type of Therapy Works Best?

Cited by 8 publications

References 104 publications

Combined Exposure to 33 Trace Elements and Associations With the Risk of Oral Cancer: A Large-Scale Case-Control Study

Combined Exposure to 33 Trace Elements and Associations With the Risk of Oral Cancer: A Large-Scale Case-Control Study

A Multidisciplinary Approach to Complex Dermal Sarcomas Ensures an Optimal Clinical Outcome

Weichgewebesarkome im Kopf-Hals-Bereich: Aktuelle Therapie – Teil 2

Contact Info

Product

Resources

About