Epithelial–myoepithelial carcinoma arising in the nasal cavity

Yamanegi, Koji; Uwa, Nobuhiro; Hirokawa, Mitsuyoshi; Ohyama, Hideki; Hara, Masaki; Yamada, Naoko; Ogino, Kōichi; Toh, Kunichika; Terada, Tomonori; Tanaka, Akio; Sakagami, Masafumi; Terada, Nobuyuki; Nakasho, Keiji

doi:10.1016/j.anl.2007.10.001

Cited by 30 publications

(37 citation statements)

References 20 publications

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“…Immunohistochemical studies may be useful in facilitating the differentiation of EMCa from similar tumors via identification of the characteristic bi-layered epithelial-myoepithelial phenotype (1). On immunohistochemical staining, the epithelial cells are positive for epithelial markers, including cytokeratins and epithelial membrane antigen, but negative for myoepithelial cell markers, for example α-smooth muscle actin, P63 and vimentin, thus indicating their epithelial nature (2). By contrast, the cells surrounding these duct-forming cells exhibit antagonistic characteristics; they are positive for myoepithelial cell markers but negative for epithelial cell markers, demonstrating their myoepithelial nature (2,9).…”

Section: Discussionmentioning

confidence: 98%

“…Epithelial-myoepithelial carcinoma (EMCa) is a malignant biphasic salivary-type tumor, which is typically composed of large, clear myoepithelial cells surrounding variable proportions of epithelial-lined ducts that resemble intercalated ducts (1,2). EMCa predominantly arises in the parotid gland, accounting for ~1% of all salivary gland tumors (2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%

“…EMCa predominantly arises in the parotid gland, accounting for ~1% of all salivary gland tumors (2)(3)(4). Immunohistochemical studies are useful in the differentiation of EMCa from other similar tumors, highlighting their characteristic biphasic epithelial-myoepithelial phenotype (1).…”

Section: Introductionmentioning

confidence: 99%

“…However, several cases of EMCa have been reported in the mucoserous glands of the upper and lower aerodigestive tract (1,3), including the paranasal sinuses (2), nasopharynx (3), nasal cavity (2), hypopharynx (4), larynx (4), trachea (2,4), bronchus (2) and lungs (5). Additionally, the development of EMCa at unusual sites, for example the breast (2) and lacrimal glands (2,4), has been reported.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, the development of EMCa at unusual sites, for example the breast (2) and lacrimal glands (2,4), has been reported.…”

Section: Introductionmentioning

confidence: 99%

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Epithelial-myoepithelial carcinoma of the nasopharynx: A case report and review of the literature

et al. 2015

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Abstract. An 80-year-old female with complaints of right-sided nose blockage and occasional epistaxis for several months was referred to Sanggye Paik Hospital (Seoul, Korea). Nasal examination revealed a hemorrhagic mass protruding towards the right posterior nasal cavity, for which the patient was subjected to excisional biopsy. The pathological diagnosis was epithelial-myoepithelial carcinoma, as immunohistochemical analysis revealed that the inner cells stained positive for cytokeratin 7, an epithelial cell marker, whereas the outer cells stained positive for smooth muscle actin and P63, consistent with a myoepithelial phenotype. The patient received concurrent chemoradiation therapy followed by systemic chemotherapy. Following the achievement of a partial response, the patient's treatment course was uneventful. Follow-up at 24 months revealed a stable status at partial response, with no subsequent progression.

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Section: Discussionmentioning

confidence: 98%