Epithelial-myoepithelial carcinoma of the nasopharynx: A case report and review of the literature

Abstract

Abstract. An 80-year-old female with complaints of right-sided nose blockage and occasional epistaxis for several months was referred to Sanggye Paik Hospital (Seoul, Korea). Nasal examination revealed a hemorrhagic mass protruding towards the right posterior nasal cavity, for which the patient was subjected to excisional biopsy. The pathological diagnosis was epithelial-myoepithelial carcinoma, as immunohistochemical analysis revealed that the inner cells stained positive for cytokeratin 7, an epithelial cell marker, whereas the outer cells stained positive for smooth muscle actin and P63, consistent with a myoepithelial phenotype. The patient received concurrent chemoradiation therapy followed by systemic chemotherapy. Following the achievement of a partial response, the patient's treatment course was uneventful. Follow-up at 24 months revealed a stable status at partial response, with no subsequent progression.

A novel low‐grade nasopharyngeal adenocarcinoma characterized by a GOLGB1‐BRAF fusion gene

“…16 The gamut of salivary-type adenocarcinomas has been reported in the nasopharynx. [4][5][6][7][8][9][10][11] Unsurprisingly, the histopathologic and F I G U R E 1 Representative photomicrographs of low-grade nasopharyngeal adenocarcinoma, with GOLGB1-BRAF fusion gene (Hematoxylin and Eosin). A, Lowpower magnification showing irregularly shaped invasive glands containing micropapillary luminal projections.…”

“…Adenocarcinoma of the nasopharynx ostensibly includes nasopharyngeal papillary adenocarcinoma and salivary gland tumors. 1,[4][5][6][7][8][9][10][11][12] Herein, we report the case of an adult male who presented with a distinctive nasopharyngeal tumor. Morphologically, it did not correspond to any established subtype of nasopharyngeal adenocarcinoma, and was initially diagnosed as nasopharyngeal adenocarcinoma, not otherwise specified (NOS).…”

“…Unlike NPC, the pathogenesis of this heterogeneous group of malignancies remains poorly characterized. Adenocarcinoma of the nasopharynx ostensibly includes nasopharyngeal papillary adenocarcinoma and salivary gland tumors 1,4‐12 …”

Epithelial Myoepithelial Carcinoma of the Nasal Cavity: Clinical, Histopathological, and Immunohistochemical Distinction of a Case Report

“…They have been reported in other head and neck regions, such as the pharynx, nasal cavity, paranasal sinuses, external ear canal, lachrymal gland, and trachea. 3,4,14-22…”

Sinonasal epithelial-myoepithelial carcinoma: Report of a novel subsite and review of the literature

“…Epithelial-myoepithelial carcinoma (EMC) is an extremely rare neoplasm that typically occurs in the major salivary glands, predominantly the parotid, 1 although it has also been reported in the external auditory canal, 2,3 lacrimal gland, 4–6 nasopharynx, 7,8 palate, 9,10 floor of the mouth, 11 buccal mucosa, 12 base of the tongue, 13,14 larynx, 15 subglottis, 16,17 hypopharynx, 18 trachea, 19 lung, 20–23 liver, 24 and Bartholin gland. 25 EMC was first described in 1972 26 and is histologically a biphasic tumor that consists of clear-staining myoepithelial cells surrounding epithelial-lined ductal cells.…”