Epithelial Myoepithelial Carcinoma of the Nasal Cavity: Clinical, Histopathological, and Immunohistochemical Distinction of a Case Report

Nguyen, Sally; Perron, Marjorie; Nadeau, Sylvie; Odashiro, Alexandre Nakao; Corriveau, Marie-Noëlle

doi:10.1177/1066896917747732

Cited by 11 publications

(3 citation statements)

References 23 publications

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“…However, such data are more applicable to classic quiescent EMC than higher grade or RT-associated EMC. RT has been included in treatment plans since WHO inclusion in 1991, and some authors advocate for a refined incorporation of adjuvant RT in the setting of recurrent or high risk EMC[22,23]. Metastatic cases, while uncommon, have a poor prognosis when observed without chemoradiotherapy[24].…”

Section: Discussionmentioning

confidence: 99%

Radiation-associated epithelial-myoepithelial carcinoma among five secondary malignancies: A case report and review of literature

Khattab

Sherry

Ahlers

et al. 2018

WJCO

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BACKGROUNDEpithelial-myoepithelial carcinoma (EMC) is a rare, low-grade, malignant tumor that constitutes less than one percent of all salivary gland tumors. To date, only one other case report has described radiation-associated EMC in the English language medical literature.CASE SUMMARYIn this report, we describe the case of a 56-year-old male patient who presented with a neck mass diagnosed as EMC of the left submandibular gland approximately 30 years after mantle field radiation and chemotherapy for Hodgkin lymphoma. Treatment included resection, re-resection with nodal dissection, and adjuvant chemoradiotherapy. This patient was also diagnosed with 4 other secondary malignancies, including stage IV diffuse large B cell lymphoma in the abdomen with subsequent brain metastases, low-grade neuroendocrine carcinoma of the lung, Hurthle cell adenoma, and small B cell lymphoma before the patient expired. This case provides important information regarding the pathology, clinical sequelae, and management of a patient diagnosed with radiation-associated EMC amidst four concurrent malignancies.CONCLUSIONFurther investigation is needed on the efficacy of adjuvant radiotherapy in EMC, especially atypical EMC.

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Section: Discussionmentioning

confidence: 99%

Radiation-associated epithelial-myoepithelial carcinoma among five secondary malignancies: A case report and review of literature

Khattab

Sherry

Ahlers

et al. 2018

WJCO

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“…Of all the types of nasopharyngeal malignancies treated at our center, the incidence of EMCa is 1/315 (0.3%) as of 2021. This tumor can occur in unusual sites, such as the breast (13)(14)(15), pituitary gland (16), paranasal sinus (9,17,18), lacrimal gland (19)(20)(21)(22), nasal cavity (1,3,6,(23)(24)(25), trachea and bronchus (26,27), lung (28)(29)(30)(31)(32)(33)(34), nasopharynx (4,5), and even the pleura mediastinalis (35). EMCa was first reported by Donath in 1972, and 8 patients have been reported with a salivary gland tumor that was termed EMCa (36).…”

Section: Introductionmentioning

confidence: 99%

Epithelial–myoepithelial carcinoma of the nasopharynx: A case report and review of the literature

Zhang

Wang

et al. 2022

Front. Oncol.

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BackgroundEpithelial–myoepithelial carcinoma (EMCa) is a rare low-grade malignant tumor that most commonly occurs in the salivary glands, with approximately 320 cases having been reported worldwide. Here, we report the third case of EMCa occurring in the nasopharynx. Rare cases in the breast, pituitary gland, lacrimal gland, nose, paranasal sinus, nasal cavity, trachea and bronchus, lung, and even the pleura mediastinalis have also been reported. Histopathology and immunohistochemistry are useful for confirming the diagnosis of EMCa, which is characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells and stains for different markers in each layer. However, because of the rarity of EMCa, the clinicopathological characteristics and treatment of these patients remain unclear.Case presentationWe report a rare case of EMCa of the nasopharynx. A 51-year-old man presented with a 5-month history of pain while swallowing and aggravation accompanied by right ear tinnitus lasting for 1 month. Nasopharyngoscopy and magnetic resonance imaging (MRI) of the nasopharynx and neck revealed a 5.6 cm × 3.4 cm × 3.1 cm mass in the nasopharyngeal space, invasion of the right cavernous sinus, and lymph node enlargement in the right retropharyngeal space. On 17 April 2019, based on the histopathological and immunohistochemical features, a final diagnosis of EMCa of the right nasopharynx was made. The patient underwent concurrent chemoradiotherapy (CCRT), and his symptoms were relieved after treatment. On 10 January 2022, nasopharynx MRI and biopsy revealed local recurrence, but chest and abdominal computed tomography (CT) showed no obvious signs of metastasis. The local recurrence-free survival (LRFS) period was 33 months.ConclusionTo the best of our knowledge, this is the third reported case of EMCa in the nasopharynx and the only case of EMCa in the nasopharynx treated with CCRT, and a partial response was achieved. Therefore, to improve the quality of life and prognosis of patients with unresectable tumors, we believe that CCRT is a suitable option. Further clinical observations are required to elucidate the pathophysiology and prognosis of EMCa.

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“…Epithelial-Myoepthial Carcinoma (EMC) is locally aggressive, lowgrade tumor of duct -like structures composed of two cell type: small, inner duct lining cells and larger, peripheral myoepithelial cells.it represent 1% of all salivary gland neoplasm and over 75% occur in the parotid gland. Epithelial-myoepthial carcinoma EMC is histopathological term used to describe the biphasic pattern of clear staining of the myoepithelial cells surrounding variable proportions of the ducts with an epithelial lining [1]. EMC is a rare neoplasm, first described in 1972 by Donath et al [7].…”

Section: Introductionmentioning

confidence: 99%

Primary Salivary Gland Neoplasms (Malignant) Epithelial Myoepthial Carcinoma: A Case Report

saeed¹,

Yeslam²

2022

CCRS

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Epithelial myoepthial carcinoma (EMEC) is rare, low grad tumor with epithelial and myoepithelial components and frequent local recurrence, also called glycogen rich adenoma (clear cell pattern), myoepithelioma (spindle and plamocytiod patterns), myoepithelial carcinoma (if only myoepithelial differentiation and marked cytologic atypia). Occurs most frequently in the major salivary glands and accounts for approximately 1% of all salivary gland neoplasms that usually occurs in parotid gland but can be occur in variety of sites such as the nasal cavity, paranasal sinus and base of the tong. In fact, due to the rarity of the epithelial myoepithelial carcinoma,there is no uniformity of data in the literature band vary different therapeutic strategies have been suggested.

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Epithelial Myoepithelial Carcinoma of the Nasal Cavity: Clinical, Histopathological, and Immunohistochemical Distinction of a Case Report

Abstract: Different variants of EMCs exist, such as oncocytic EMC. EMCs should be treated aggressively because they can be locally invasive, recur, and give rise to distant metastases.

Cited by 11 publications

References 23 publications

Radiation-associated epithelial-myoepithelial carcinoma among five secondary malignancies: A case report and review of literature

Radiation-associated epithelial-myoepithelial carcinoma among five secondary malignancies: A case report and review of literature

Epithelial–myoepithelial carcinoma of the nasopharynx: A case report and review of the literature

Primary Salivary Gland Neoplasms (Malignant) Epithelial Myoepthial Carcinoma: A Case Report

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