Epimedium elatum (Morr &amp; Decne): A Therapeutic Medicinal Plant from Northwestern Himalayas of India

Lone, Sajad Ahmad; Gupta, Ajai Prakash; Manzoor, Malik Muzafar; Goyal, Pooja; Hassan, Qazi P.; Gupta, Suphla

doi:10.1007/978-3-319-93997-1_17

Cited by 7 publications

(7 citation statements)

References 119 publications

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“…Moreover, flavonoids are powerful antioxidants with anti-inflammatory, anti-neoplastic, anti-cancer, anti-allergic, anti-viral and hepatoprotective properties (Lewis et al 1999 ; Xi et al 2014 ; Xie et al 2015 ; Ogbonna et al 2016 ). According to data from in vitro and in vivo investigations, epimedin compounds have strong anticancer effect against a wide spectrum of cancer cells via a variety of pathways including apoptosis, cell cycle regulation, anti-angiogenesis, anti-metastasis, and immunological modulation (Tan et al 2016 ; Lone et al 2018 ). In another investigation on E. koreanum , all four Epimedium species markers, epimedin A, epimedin B, epimedin C and icariin showed high anticancer potential (Yasukawa et al 2016 ).…”

Section: Discussionmentioning

confidence: 99%

In vitro evaluation of bioactive properties of banana sap

et al. 2022

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Banana sap is currently designated as a waste subsequent to utilization of pseudo stem in pulp and paper industry as well as other applications which is contributing to the environmental pollution. In the present study, banana sap and its crude extracts were evaluated for antimicrobial, antioxidant and anticancer properties. The role of oxidized and un-oxidized banana sap for its antimicrobial potential against a microbial test panel comprising gram positive as well as gram negative bacteria and Candida albicans using in vitro micro broth dilution assay. The un-oxidized banana sap exhibited a significantly higher antibacterial potential as evident by a lower minimal inhibitory concentration (MIC) ranging between 15.625 to 62.5 mg/mL. In vitro radical scavenging activity of dichloromethane (DCM) extract of banana sap by DPPH method exhibited 54.62 ± 1.09 (µg/mL) IC 50 value at the concentration of 1 mg/mL. Dichloromethane extract of banana sap showed maximum cytotoxic effect with human breast cancer (MCF-7) cell proliferation at the concentration of 100 µg/mL which was 78.37 ± 0.05% and the cytotoxic effect significantly increased with increasing concentration of banana sap extract. Furthermore, LCMS studies revealed the presence of bioactive compounds in dichloromethane extract of banana sap, such as rescinnamine derivative, dihydrorescinnamine and epimedin A. The present study suggested that banana sap is a promising source of bioactive compounds with relevant antimicrobial, antioxidant and anticancer properties.

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Section: Discussionmentioning

confidence: 99%

In vitro evaluation of bioactive properties of banana sap

et al. 2022

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“…In addition, they are used in the treatment of osteoporosis, rheuma, hepatitis, leukopenia, car-diovascular problems, infertility in Europe, Korea, Japan and China. [4,5] Many dietary supplement prepared from Epimedium plants are commercially available for aphrodisiac, tonic and antirheumatic effects. [6] More than 260 chemically active components have been identified in Epimedium species.…”

Section: Introductionmentioning

confidence: 99%

“…Aerial parts and roots of plants belonging to the Epimedium genus are traditionally employed in the treatment of respiratory system disease such as asthma and lung cancer, as well as being used as a diaphoretic. In addition, they are used in the treatment of osteoporosis, rheuma, hepatitis, leukopenia, cardiovascular problems, infertility in Europe, Korea, Japan and China [4,5] . Many dietary supplement prepared from Epimedium plants are commercially available for aphrodisiac, tonic and antirheumatic effects [6] .…”

Section: Introductionmentioning

confidence: 99%

Insights into the Biological Activity and Cytotoxic Mechanism of Epimedium pubigerum

Seyhan,

Akkaya,

Kolci

et al. 2023

Chemistry & Biodiversity

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In this work, the phytochemical characterization, biological activity, and cytotoxic mechanism of aerial and rhizome methanol extracts (SME and RME) of Epimedium pubigerum were investigated to demonstrate its potential usage in the treatment of lung cancer. LC‐HRMS analysis, total phenolic/flavonoid content assay, DPPH radical scavenging assay, DNA interaction, cytotoxicity, and western blotting were investigated using different methods. Fumaric acid was found to be the most abundant compound in both extracts. SME and RME were cytotoxic on A549 cells concentration‐dependently. Also, in vitro scratch assay showed that SME and RME led to a significant anti‐migratory effect at 1 mg/mL. Cytochrome c, p53, and caspase 3 expression significantly increased in the presence of RME compared to the control. All of these results claimed that RME might be suggested as a theoretically more effective phytotherapeutic agent for lung cancer compared to the effect seen with the SME.

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“…Due to their special nourishing effects on kidney and bones, the leaves and rhizomes of Epimedium plants have long been used in traditional Chinese medicine (GMP, 2019;CP, 2020). Meanwhile, bearing beautiful evergreen heart-shaped leaves, and magnificent "spiderlike" flowers, Epimedium plants are popular as garden plants for groundcover and ornamental decoration in Europe, North America and Japan (usually known as barrenworts) (Ma et al, 2011;Lone et al, 2018). Among Epimedium species, the leaves and rhizomes of attractive purplish red flowers have endowed it with great cultivation prospects, and therefore was selected for current study.…”

Section: Introductionmentioning

confidence: 99%

New 8-prenylated quercetin glycosides from the flowers of Epimedium acuminatum and their testosterone production-promoting activities

Zhang

Zeng

et al. 2022

Front. Chem.

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Phytochemical investigation was carried out for the flowers of Epimedium acuminatum Franchet. by first conducting LC-MS analysis, leading to the identification of 32 compounds. Furthermore, guided by LC-MS profiling, three new 8-prenylated quercetin glycosides (3′-hydroxylikarisoside C, 3′-hydroxylepimedoside E, 3′-hydroxyldiphylloside B), one new anthocyanin (delphinidin-3-O-p-coumaroyl-sophoroside) and six known compounds were isolated from the flowers of E. acuminatum for the first time, and their structures were characterized based on spectroscopic methods including 1D and 2D NMR, and HRESIMS. Combining our discoveries and literature survey, a revised classification of Epimedium flavonols was proposed as Type A (8-prenylated kaempferol based), which was further subdivided into subtype icaritin and subtype demethylicaritin, and Type B (8-prenylated quercetin based), which was further subdivided into subtype 3′-hydroxylicaritin and subtype 3′-hydroxyldemethylicaritin. The structure-activity relationship (SAR) study was carried out by comparing testosterone production-promoting activities of all the new compounds along with nine related Epimedium flavonols, revealing that the new 8-prenylated quercetin glycosides (subtype 3′-hydroxyldemethylicaritin in Type B) exhibited lower testosterone production-promoting activities in rat primary Leydig cells than Epimedium flavonols of subtype demethylicaritin in Type A, but possessed higher activities than the Epimedium flavonols of subtype icaritin in Type A. These results suggested that either methylation at C-4′ position or hydroxylation at C-3′ position of ring B could significantly reduce the testosterone production-promoting activities of Epimedium flavonols.

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Epimedium elatum (Morr & Decne): A Therapeutic Medicinal Plant from Northwestern Himalayas of India

Cited by 7 publications

References 119 publications

In vitro evaluation of bioactive properties of banana sap

In vitro evaluation of bioactive properties of banana sap

Insights into the Biological Activity and Cytotoxic Mechanism of Epimedium pubigerum

New 8-prenylated quercetin glycosides from the flowers of Epimedium acuminatum and their testosterone production-promoting activities

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