Epidural spinal cord compression as initial clinical presentation of an acute myeloid leukaemia: case report and literature review

Oka, Dominique N’Dri; Bah, Abdellah; Tokpa, André; Derou, Louis

doi:10.1186/s41016-015-0020-5

Cited by 7 publications

(6 citation statements)

References 14 publications

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“…21,22 The most frequent spinal localization of myeloid sarcoma is in the thoracic region, followed by the lumbar and sacral area. 3 Our patient had lesions both in the thoracic as well as lumbosacral areas.…”

Section: Myeloid Sarcomasmentioning

confidence: 67%

“…22 Though adequately treated with chemotherapy, radiotherapy or even surgical decompression, some neurologic symptoms do not resolve probably secondary to the damage already imparted on the neurons. 3,22 Some patients succumb to complications such as in the case of our patient who developed catheter-related urinary tract infection. 3 In past studies, myeloid sarcomas are encountered in around 15% of patients presenting with an AML associated with t(8;21).…”

Section: Myeloid Sarcomasmentioning

confidence: 85%

“…dISCuSSIon AML is the most common acute leukemia in adults and accounts for approximately 80% of cases in the patient's age group. 2,3 In contrast, AML accounts for less than 10 percent of acute leukemias in children less than 10 years of age. In adults, the median age at diagnosis is approximately 65 years.…”

Section: Case Presentationmentioning

confidence: 99%

“…It may also be the initial presentation of relapse. 3 Myeloid sarcomas in patients with AML are usually found in the bone, skin, soft tissue and lymph nodes. 4 Central nervous system (CNS) involvement is rare, present in only around 3-9% of AML patients.…”

Section: Introductionmentioning

confidence: 99%

“…[5][6][7] Spinal cord compression due to myeloid sarcoma as an initial manifestation of AML is very rare with only few reported cases. 3 The predominantly neurologic presentation can mislead the diagnosis and delay the subsequent appropriate management of these patients. We present a case of a Filipino male with intradural extramedullary myeloid sarcoma causing compression of the thoracic and lumbar spinal cord as the initial presentation of AML.…”

Section: Introductionmentioning

confidence: 99%

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Intradural Extramedullary Tumor Causing Compression of the Thoracic and Lumbar Vertebrae in a 22-year-old Male with Acute Myeloid Leukemia

Leon¹,

Tanchanco²,

Mirasol³

et al. 2020

Acta Med Philipp

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Myeloid sarcoma, characterized by the presence of immature myeloid cells occurring at an extramedullary site, is a rare manifestation of acute myelogenous leukemia (AML). Spinal cord compression as an initial presentation of AML is very rare with only a few reported cases. We discuss a case of a 22-year-old male who presented with bicytopenia and paraplegia. Workups were consistent with AML with monocytic differentiation. Chromosomal analysis revealed loss of Y and t (8;21). Spinal cord MRI showed intradural extramedullary-enhancing soft tissue lesions at levels T2 to T7 and L5 to S1, suspected to be myeloid sarcoma. Patient, however, succumbed to severe nosocomial infection prior to initiation of chemotherapy and radiotherapy.

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Section: Myeloid Sarcomasmentioning

confidence: 67%

Section: Myeloid Sarcomasmentioning

confidence: 85%

Section: Case Presentationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Intradural Extramedullary Tumor Causing Compression of the Thoracic and Lumbar Vertebrae in a 22-year-old Male with Acute Myeloid Leukemia

Leon¹,

Tanchanco²,

Mirasol³

et al. 2020

Acta Med Philipp

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Neurosurgical simulator for training aneurysm microsurgery—a user suitability study involving neurosurgeons and residents

et al. 2020

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Background Due to its complexity and to existing treatment alternatives, exposure to intracranial aneurysm microsurgery at the time of neurosurgical residency is limited. The current state of the art includes training methods like assisting in surgeries, operating under supervision, and video training. These approaches are labor-intensive and difficult to fit into a timetable limited by the new work regulations. Existing virtual reality (VR)–based training modules lack patient-specific exercises and haptic properties and are thus inferior to hands-on training sessions and exposure to real surgical procedures. Materials and methods We developed a physical simulator able to reproduce the experience of clipping an intracranial aneurysm based on a patient-specific 3D-printed model of the skull, brain, and arteries. The simulator is made of materials that not only imitate tissue properties including arterial wall patency, thickness, and elasticity but also able to recreate a pulsatile blood flow. A sample group of 25 neurosurgeons and residents (n = 16: early residency with less than 4 years of neurosurgical exposure; n = 9: late residency and board-certified neurosurgeons, 4–15 years of neurosurgical exposure) took part to the study. Participants evaluated the simulator and were asked to answer questions about surgical simulation anatomy, realism, haptics, tactility, and general usage, scored on a 5-point Likert scale. In order to evaluate the feasibility of a future validation study on the role of the simulator in neurosurgical postgraduate training, an expert neurosurgeon assessed participants’ clipping performance and a comparison between groups was done. Results The proposed simulator is reliable and potentially useful for training neurosurgical residents and board-certified neurosurgeons. A large majority of participants (84%) found it a better alternative than conventional neurosurgical training methods. Conclusion The integration of a new surgical simulator including blood circulation and pulsatility should be considered as part of the future armamentarium of postgraduate education aimed to ensure high training standards for current and future generations of neurosurgeons involved in intracranial aneurysm surgery.

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Downregulatory effect of miR-342-3p on epileptogenesis in the PTZ-kindling model

et al. 2022

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Epidural spinal cord compression as initial clinical presentation of an acute myeloid leukaemia: case report and literature review

Cited by 7 publications

References 14 publications

Intradural Extramedullary Tumor Causing Compression of the Thoracic and Lumbar Vertebrae in a 22-year-old Male with Acute Myeloid Leukemia

Intradural Extramedullary Tumor Causing Compression of the Thoracic and Lumbar Vertebrae in a 22-year-old Male with Acute Myeloid Leukemia

Neurosurgical simulator for training aneurysm microsurgery—a user suitability study involving neurosurgeons and residents

Downregulatory effect of miR-342-3p on epileptogenesis in the PTZ-kindling model

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