Epidemiology of renal disease in Romania: a 10 year review of two regional renal biopsy databases

Covic, Adrian; Schiller, Adalbert; Volovat, Carmen; Gluhovschi, Gheorghe; Gusbeth‐Tatomir, Paul; Petrică, Ligia; Căruntu, Irina-Draga; Bozdog, Gheorghe; Velciov, Silvia; Trandafirescu, Virginia; Bob, Flaviu; Gluhovschi, Cristina

doi:10.1093/ndt/gfi207

Cited by 131 publications

(168 citation statements)

References 12 publications

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“…This finding was in accordance with the studies including large series of biopsies. [2][3][4] Similar with the studies in the literature including large series of biopsies, this study as well showed that the glomerular diseases were more frequent among males. 2,3,6,7 No significant difference was found between the patients with primary and secondary GN in terms of gender and age.…”

Section: Discussionsupporting

confidence: 82%

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Comparison of the Clinical and Laboratory Presentations of Primary and Secondary Glomerular Diseases

et al. 2011

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Objective: To investigate the clinicopathologic correlation of the glomerular diseases and to compare the presentations of primary and secondary glomerular diseases. Methods: Two hundred and sixty adult patients (men = 56.2%, mean age = 39.9 ± 16.0 years) who had undergone renal biopsy and been diagnosed with glomerular disease were retrospectively investigated. The information about the demographic and clinical characteristics of the patients, the indications for biopsy, the laboratory parameters, and the pathological results of the biopsies were obtained from the medical records. Primary and secondary glomerulonephritis (GN) groups were compared in terms of their demographic characteristics, indications for biopsy, and laboratory parameters. Results: Percent of patients with primary and secondary GN were 63.5% and 36.5%, respectively. The most common indication for biopsy was nephrotic syndrome (53.8%) in all patients. It was found that presentation with impaired renal function was more prevalent in the secondary GN group when compared with the primary GN group (54.7% vs. 35.8%, p < 0.05). Among the inflammation parameters, the levels of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were found to be significantly higher in the secondary GN group when compared with the primary GN group (ESR = 85.2 ± 30.4 mm/h vs. 56.3 ± 30.7 mm/h, p < 0.001; CRP = 42.1 ± 39.6 mg/L vs. 21.7 ± 40.2 mg/L, p < 0.001). Conclusions: The clinicopathologic correlation of GN was found similar with the larger studies in the literature. This study also indicated that the rate of patients with secondary GN was not low, and the inflammation parameters were higher in the secondary GN groups.

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Section: Discussionsupporting

confidence: 82%

“…Primary GNs are more common than secondary GNs. [2][3][4] The presence of an underlying secondary reason that would change the therapy approach should be investigated in each glomerular disease independent from its investigated. All of the biopsy samples were obtained from to the native kidneys.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Clinical and Laboratory Presentations of Primary and Secondary Glomerular Diseases

et al. 2011

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“…Since 128,057,352 people resided in Japan in 2010, the estimated rate of renal biopsy was 140.6 to 164.0 per million population. This rate was higher than that in Romania [24], Spain [25], the Czech Republic [10], Denmark [26], and Scotland [27], was similar to that in France [28], and was lower than that in USA, Finland [29], and Australia [30].…”

Section: Discussion and Commentsmentioning

confidence: 58%

Japan Renal Biopsy Registry and Japan Kidney Disease Registry: Committee Report for 2009 and 2010

et al. 2013

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123Clin Exp Nephrol (2013) 17:155-173 DOI 10.1007 nephritic syndrome (55.4 % and 50.0 % in 2009 and 2010, respectively), followed by nephrotic syndrome (22.4 % and 27.0 %); the most frequent pathological diagnosis as classified by the pathogenesis was IgA nephropathy (31.6 % and 30.4 %), followed by primary glomerular diseases (except IgA nephropathy) (27.2 % and 28.1 %). Among the primary glomerular diseases (except IgA nephropathy) in the patients with nephrotic syndrome, membranous nephropathy was the most common histopathology in 2009 (40.3 %) and minor glomerular abnormalities (50.0 %) were the most common in 2010 in native kidneys in the J-RBR. Five new secondary and longitudinal research studies by the J-KDR were started in 2009 and one was started in 2010.

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“…In addition, data from local or limited national registries of renal biopsy have been reported from South Korea [10,11], Bahrain [12,13], Brazil [14], Romania [15], China [16], Finland [17], Serbia [18], Pakistan [19] and Belgium [20]. Finally, there are also reports that include epidemiological data only on glomerular diseases from Australia [21], Macedonia [22], France [23], USA [24], Iran [25], Germany [26], Lebanon [27], Peru [28] and Poland [29].…”

Section: Introductionmentioning

confidence: 99%

Epidemiologic data of adult native biopsy-proven renal diseases in Croatia

et al. 2013

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PURPOSE: There is a paucity of epidemiological data on biopsy-proven renal disease in Croatia. The purpose of this report is a review of clinical and histological data, over a period of 15 years, from the single biggest adult native renal biopsy centre in Croatia.METHODS: This report includes data from 922 adult native renal biopsies in patients referred from the whole country and performed in our centre from 1996 till February 2012. Data on age, gender, serum creatinine, urine sediment, 24-hour proteinuria, clinical syndrome and histological diagnosis were collected and analyzed retrospectively. In all patients light, immunofluorescence and electron microscopic analysis was performed.RESULTS: The median age of the patients was 48 years (interquartile range 36-59 years), and the majority of patients were men (57.8%). The most common indication for renal biopsy was nephrotic syndrome (40.3%) followed by asymptomatic urinary abnormalities (31.7%). The most common biopsy-proven renal disease in total was IgA glomerulonephritis (19.3%), followed by FSGS (15.8%) and membranous glomerulonephritis (9.2%). In men similar results were found, while in women the most common were hereditary nephritis (13.4%), FSGS (12.9%) and connective tissue disease-related glomerular disorders (11.6%).CONCLUSION: The presented data are an important contribution to the better understanding of the epidemiology of biopsy-proven renal disease in Croatia and Europe throughout comparison with other registry data. This data should be the basis for the formation of Croatian Registry of Renal Biopsies.

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Epidemiology of renal disease in Romania: a 10 year review of two regional renal biopsy databases

Cited by 131 publications

References 12 publications

Comparison of the Clinical and Laboratory Presentations of Primary and Secondary Glomerular Diseases

Comparison of the Clinical and Laboratory Presentations of Primary and Secondary Glomerular Diseases

Japan Renal Biopsy Registry and Japan Kidney Disease Registry: Committee Report for 2009 and 2010

Epidemiologic data of adult native biopsy-proven renal diseases in Croatia

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