Epidemiologic data of adult native biopsy-proven renal diseases in Croatia

Abstract

PURPOSE: There is a paucity of epidemiological data on biopsy-proven renal disease in Croatia. The purpose of this report is a review of clinical and histological data, over a period of 15 years, from the single biggest adult native renal biopsy centre in Croatia.METHODS: This report includes data from 922 adult native renal biopsies in patients referred from the whole country and performed in our centre from 1996 till February 2012. Data on age, gender, serum creatinine, urine sediment, 24-hour proteinuria, clinical syndrome and histological diagnosis were collected and analyzed retrospectively. In all patients light, immunofluorescence and electron microscopic analysis was performed.RESULTS: The median age of the patients was 48 years (interquartile range 36-59 years), and the majority of patients were men (57.8%). The most common indication for renal biopsy was nephrotic syndrome (40.3%) followed by asymptomatic urinary abnormalities (31.7%). The most common biopsy-proven renal disease in total was IgA glomerulonephritis (19.3%), followed by FSGS (15.8%) and membranous glomerulonephritis (9.2%). In men similar results were found, while in women the most common were hereditary nephritis (13.4%), FSGS (12.9%) and connective tissue disease-related glomerular disorders (11.6%).CONCLUSION: The presented data are an important contribution to the better understanding of the epidemiology of biopsy-proven renal disease in Croatia and Europe throughout comparison with other registry data. This data should be the basis for the formation of Croatian Registry of Renal Biopsies.

Non‐diabetic renal disease in patients with type 2 diabetes: a single centre study

“…24 Several post studies revealed that long duration of diabetes, the presence of diabetic retinopathy and poor glycaemic control may correlate with DN. 5,10,12,[24][25][26] Combination with the results of this study, diabetic retinopathy and glycaemic control are significant predictors for the identification of NDRD and DN.…”

“…Identifying and monitoring DN relies upon assessments of kidney function, usually with an eGFR <60 mL/min/1.73 m 2 , and kidney damage, usually by estimation of albuminuria >30 mg/g creatinine . Several post studies revealed that long duration of diabetes, the presence of diabetic retinopathy and poor glycaemic control may correlate with DN . Combination with the results of this study, diabetic retinopathy and glycaemic control are significant predictors for the identification of NDRD and DN.…”

Epidemiology of biopsy‐proven glomerulonephritis in Queensland adults

“…Of note, MN was more commonly identified than FSGS for adults presenting with the nephrotic syndrome. This is also seen in Korea, Japan, China, Italy and Spain, whereas FSGS is more prominently seen in most recent studies from Malaysia, USA, Croatia and Brazil …”

“…The average patient age at biopsy was 48 ± 17 years, which is at the higher end of adult populations worldwide – 39 (±15) years in Romania and Serbia; 47–50 (±18) years in USA, Northern Ireland and Croatia; and 52 (±14) years in France . This study suggests that GN incidence increases with age, mainly attributable to the increasing incidence of CrGN, DN and MN with age.…”

Renal Biopsy in 2015 - From Epidemiology to Evidence-Based Indications

“…The most frequent histological patterns related to primary NS in adults are MN, FSGS and MCD [52,53] . However, cases of NS were also found to be due to diabetes, systemic lupus erythematosus (SLE), infections, multiple myeloma, amyloidosis or neoplasias [54] .…”