Epidemiology of infection by serotypes D to K of chlamydia trachomatis.

Dunlop, E. M. C.; Darougar, S; Treharne, J D

doi:10.1136/sti.56.3.163

Cited by 8 publications

(7 citation statements)

References 35 publications

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“…Another very interesting finding in this study is that IFN-␥ KO mice intranasally infected with MoPn exhibited endocar-ditis and pericarditis. Endocarditis caused by C. trachomatis infection has been reported in previous clinical studies (6,7,24,33). Several individual cases of chlamydial endocarditis caused by C. pneumoniae have also been documented in clinical practice over the past decade (5,13,20).…”

Section: Discussionmentioning

confidence: 85%

“…Chlamydiae, especially Chlamydia pneumoniae, are highly associated with cardiovascular diseases including atherosclerosis (8,11,17,21,(29)(30)(31)(32). C. trachomatis, although rare, is a cause of bacterial endocardial and myocardial diseases (6,7,12,24,27,28,33). Thus far, however, few experimental studies have been carried out to directly investigate the relationship between C. trachomatis and cardiovascular pathology and to examine the protective factors involving host defense against cardiac chlamydial infection.…”

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confidence: 99%

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Chlamydia trachomatis(Mouse Pneumonitis Strain) Induces Cardiovascular Pathology following Respiratory Tract Infection

1999

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Chlamydia, especially Chlamydia pneumoniae, infection is closely associated with human cardiovascular diseases. Thus far, however, few experimental studies have been carried out to investigate whether natural C. trachomatis infection can induce cardiovascular pathological changes. In this article, we report that pulmonary infection with C. trachomatis mouse pneumonitis strain (MoPn) can induce myocardial and perivascular inflammation and fibrosis in C57BL/6 mice. The pulmonary MoPn infection appeared to be disseminated systemically, because chlamydial antigens were readily detectable in multiple organs including the cardiovascular tissues. In addition, gamma interferon gene knockout mice with a C57BL/6 genetic background showed significant endocarditis and pancarditis characterized by vegetation in aortic valves, interstitial and pericardial inflammatory cellular infiltration, and growth of the organisms in the heart following respiratory tract MoPn infection. The results indicate that C. trachomatis can induce cardiovascular diseases following respiratory tract infection and suggest that murine MoPn respiratory tract infection may be a useful experimental model for investigating cardiovascular diseases caused by chlamydial infection.

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Section: Discussionmentioning

confidence: 85%

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confidence: 99%

Chlamydia trachomatis(Mouse Pneumonitis Strain) Induces Cardiovascular Pathology following Respiratory Tract Infection

1999

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“…Persistent excretion of infectious organisms is well documented in genital chlamydial infections, particularlyin women (Dunlop, Darougar & Treharne, 1980). It is therefore interesting that ocular complications in adults are so uncommon.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies with newly developed cell culture methods for isolation of C. trachomatis have shown that there is a large reservoir of genital chlamydia in the genital tract of young, sexually promiscuous populations in Western societies (Richmond & Oriel, 1978;Dunlop, Darougar & Treharne, 1980), and prospective studies suggest that up to one in three babies born to mothers with chlamydiainfected cervices may develop a chlamydial ophthalmia in the neonatal period (Alexander et al 1977;Schachter et al 1979). Little information is available, however, on the risk of paratrachoma developing in adults with a genital chlamydial infection.…”

Section: Introductionmentioning

confidence: 99%

The presentation and incidence of paratrachoma in adults

Tullo

Richmond

Easty

1981

J. Hyg.

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Thirteen definite and 3 probable cases of chlamydial eye infection were diagnosed in young adults attending the Bristol Eye Hospital between June 1978 and May 1980, and incidence of about 1 case per 44000 per year in the 15 to 44-year-old community served by this hospital, and 1 per 100000 in the total population of this community. These patients presented with a sub-acute follicular conjunctivitis or kerato-conjunctivitis, which had usually been present for several weeks and had often failed to respond to topical chloramphenicol treatment before presentation. Sera obtained from 14 patients, all had chlamydial antibody titres of 64 or more. Over the same period of time, an estimated 2500 patients per year from the same community attended the Venereology Department at the Bristol Royal Infirmary with genital chlamydial infections. These figures suggest that chlamydial infection of the eye complicates no more than 1 in 300 chlamydial infections of the genital tract in adults.

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“…As with Chlamydia psittaci, Chlamydia trachomatis infections can involve one or more heart valves in patients with previously normal or abnormal valves (62)(63)(64)(65). In addition, a case of endocarditis associated with Chlamydia trachomatis in a patient with a congenital ventricular septal defect and no evidence of valvular disease has also been reported (66).…”

Section: Chlamydiae and Endocarditismentioning

confidence: 99%

Chlamydial infections of the heart

Odeh

Oliven

1992

Eur. J. Clin. Microbiol. Infect. Dis.

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Chlamydiae are common human pathogens, causing a broad spectrum of infectious diseases. Chlamydial infections involving the heart have been described in numerous previous reports. These organisms are documented to cause endocarditis, myocarditis and pericarditis. Furthermore, Chlamydia pneumoniae, the recently discovered respiratory pathogen, has also been implicated in coronary artery disease. For the first time the literature on involvement of the heart in chlamydial infections is reviewed. Information on the discovery of Chlamydia species is also included and the problem of the species determination of Chlamydia in interpretation of the older literature is mentioned.

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Epidemiology of infection by serotypes D to K of chlamydia trachomatis.

Abstract: Following the parallel of gonorrhoea, it seems that the use of contact tracers may be an effective method for controlling chlamydial infection.

Cited by 8 publications

References 35 publications

Chlamydia trachomatis(Mouse Pneumonitis Strain) Induces Cardiovascular Pathology following Respiratory Tract Infection

Chlamydia trachomatis(Mouse Pneumonitis Strain) Induces Cardiovascular Pathology following Respiratory Tract Infection

The presentation and incidence of paratrachoma in adults

Chlamydial infections of the heart

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