1999
DOI: 10.1128/iai.67.11.6145-6151.1999
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Chlamydia trachomatis(Mouse Pneumonitis Strain) Induces Cardiovascular Pathology following Respiratory Tract Infection

Abstract: Chlamydia, especially Chlamydia pneumoniae, infection is closely associated with human cardiovascular diseases. Thus far, however, few experimental studies have been carried out to investigate whether natural C. trachomatis infection can induce cardiovascular pathological changes. In this article, we report that pulmonary infection with C. trachomatis mouse pneumonitis strain (MoPn) can induce myocardial and perivascular inflammation and fibrosis in C57BL/6 mice. The pulmonary MoPn infection appeared to be dis… Show more

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Cited by 26 publications
(11 citation statements)
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References 41 publications
(37 reference statements)
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“…Myocarditis occurs when the host fails to control the infection. Under these circumstances, the real prevalence of Chlamydia-induced myocarditis may be higher than previously documented [33]. Infection with Chlamydia trachomatis leads to production of autoantibodies to heart muscle-specific epitopes and Chlamydia-mediated heart disease is induced [34].…”
Section: Discussionmentioning
confidence: 88%
“…Myocarditis occurs when the host fails to control the infection. Under these circumstances, the real prevalence of Chlamydia-induced myocarditis may be higher than previously documented [33]. Infection with Chlamydia trachomatis leads to production of autoantibodies to heart muscle-specific epitopes and Chlamydia-mediated heart disease is induced [34].…”
Section: Discussionmentioning
confidence: 88%
“…Myocarditis occurs when the host fails to control the infection. Under these circumstances, the real prevalence of Chlamydia‐induced myocarditis may be higher than previously documented 37. It leads to the production of heart muscle‐specific epitopes autoantibodies and Chlamydia‐mediated heart disease 38…”
Section: Discussionmentioning
confidence: 94%
“…C. trachomatis, as well as infections in both male and female reproductive tracts, are the most common sexually transmitted disease. C. trachomatis infections have also been implicated in the aetiology of heart diseases (Fan et al, 1999), as well as cofactor for many microbes including viruses such as HIV (Peters et al, 1995), HPV (human papilloma virus) (Smith et al, 2002) and most recently, the lethal SARS (severe acute respiratory syndrome) virus (Hong et al, 2003).…”
Section: Introductionmentioning
confidence: 99%