Chlamydial infections of the heart

Odeh, Majed; Oliven, Arie

doi:10.1007/bf01962368

Cited by 67 publications

(35 citation statements)

References 100 publications

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“…However, some other studies have presented lack of occurrence of this pathogen in atherosclerosis (34)(35)(36)(37). Chlamydiasis can damage heart tissue, causing valvular and other heart infections (38) and persistence is a well-known feature of Chlamydia infections (39). Chlamydophila pneumoniae was encountered in non rheumatic calcified aortic valves between 26% to 86% (2-4, 6-9).…”

Section: Patients Withmentioning

confidence: 99%

Demonstration of Chlamydophila pneumoniae, Mycoplasma pneumoniae, Cytomegalovirus, and Epstein-Barr virus in atherosclerotic coronary arteries, nonrheumatic calcific aortic and rheumatic stenotic mitral valves by polymerase chain reaction

Bayram¹,

Erdoğan²,

Ekşi³

et al. 2011

Anadolu Kardiyol Derg

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Objective: The aim of this study was to investigate whether bacterial and viral infectious agents can be demonstrated in atherosclerotic lesions of patients with coronary artery disease (CAD) as well as in stenotic aortic and mitral valves from patients undergoing heart valve replacement. Methods: In this cross-sectional study, the presence of Chlamydophila pneumoniae, Mycoplasma pneumoniae, Cytomegalovirus (CMV), and Epstein-Barr virus (EBV) was investigated by polymerase chain reaction in atherosclerotic and non-atherosclerotic vascular samples taken from patients undergoing coronary artery bypass surgery due to CAD, and from patients undergoing aortic (AVR) and/or mitral valve replacement (MVR) secondary to valvular stenosis. For statistical analyses ANOVA, Chi-square test or Fisher's exact test were used. Results: The presence of C. pneumoniae, M. pneumoniae, and CMV in atherosclerotic versus non-atherosclerotic samples was as follows: 30% vs. 16.7% (p=0.222), 6.7% vs. 3.3% (p=0.554), and 10% vs. 0% (p=0.076), respectively. In valve group, same pathogens were present in AVR and MVR patients as follows: 24.2% vs. 21. 4% (p=0.773), 9.1% vs. 7.1% (p=0.758), and 21.2% vs. 11.9% (p=0.275). EBV DNA was not detected in any of vascular specimens, but in one (3%) patient with AVR (p=0.256). Conclusion: Our results suggest that C. pneumoniae, M. pneumoniae, and CMV are present with similar frequency both in atherosclerotic and non-atherosclerotic vessels. We conclude that although non-atherosclerotic, vascular samples of CAD patients are invaded by infectious agents as like as atherosclerotic vessels. We further conclude that C. pneumoniae, M. pneumoniae, and CMV are present in stenotic aortic and mitral valves and atherosclerotic tissues with similar frequency indicating that atherosclerosis and valvular stenosis might share a common etiology related to infection. (Anadolu Kardiyol Derg 2011; 11: 237-43)

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Section: Patients Withmentioning

confidence: 99%

Demonstration of Chlamydophila pneumoniae, Mycoplasma pneumoniae, Cytomegalovirus, and Epstein-Barr virus in atherosclerotic coronary arteries, nonrheumatic calcific aortic and rheumatic stenotic mitral valves by polymerase chain reaction

Bayram¹,

Erdoğan²,

Ekşi³

et al. 2011

Anadolu Kardiyol Derg

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“…All three of the chlamydial species that infect humans (Chlamydia trachomatis, Chlamydia psittaci, and C. pneumoniae) have been associated with endocarditis and myocarditis (9). Seroepidemiological studies have associated C. pneumoniae with coronary artery disease (10)(11)(12)(13)(14) and carotid artery disease (15).…”

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confidence: 99%

Chlamydia pneumoniae (TWAR) in coronary arteries of young adults (15-34 years old).

Kuo

Grayston

Campbell

et al. 1995

Proc. Natl. Acad. Sci. U.S.A.

335

146

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Six of the 7 (86%) atheroma, 2 of the 11 (18%) with intimal thickening, and none of the 31 normal-appearing coronary samples were positive. Four were positive by PCR for cytomegalovirus, 2 from diseased arteries and 2 from normal arteries. Examination of the adjacent left coronary artery sample with a fat stain found abnormalities in 25 of the patients, but 19 still showed no evidence of atherosclerosis as a result of either examination. Thus, C. pneumoniae is found in coronary lesions in young adults with atherosclerosis but is not found in normal-appearing coronary arteries of both persons with and without other evidence of atherosclerosis.A single cause for lesions of atherosclerosis has, thus far, not been found. A number of risk factors have been discovered that enhance the rate of progression of atherosclerotic lesions and increase the frequency of its sequellae, such as myocardial infarction. The concept that causation of atherosclerosis likely involves several factors is now considered reasonable.

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“…Infectious myocarditis was reported in an infant suffering from chlamydial pneumonitis. There have been only a few reported cases of childhood myocarditis in the literature associated with C. trachomatis infection, so heart muscle cells act as an especially rare target site (Odeh & Oliven, 1992;Ringel et al, 1983).…”

Section: Rare Organ Manifestations and Complications Of C Trachomatimentioning

confidence: 99%

Chlamydia trachomatis Infections in Neonates

Balla¹,

Petrovay²

2012

Chlamydia

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Chlamydial infections of the heart

Cited by 67 publications

References 100 publications

Demonstration of Chlamydophila pneumoniae, Mycoplasma pneumoniae, Cytomegalovirus, and Epstein-Barr virus in atherosclerotic coronary arteries, nonrheumatic calcific aortic and rheumatic stenotic mitral valves by polymerase chain reaction

Demonstration of Chlamydophila pneumoniae, Mycoplasma pneumoniae, Cytomegalovirus, and Epstein-Barr virus in atherosclerotic coronary arteries, nonrheumatic calcific aortic and rheumatic stenotic mitral valves by polymerase chain reaction

Chlamydia pneumoniae (TWAR) in coronary arteries of young adults (15-34 years old).

Chlamydia trachomatis Infections in Neonates

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