Epidemiology of HCV infection in Latin America

Méndez-Sánchez, Nahúm; Gutiérrez-Grobe, Ylse; Kobashi-Margáin, Ramón A.

doi:10.1016/s1665-2681(19)31719-3

Cited by 22 publications

(11 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our investigation is in agreement with previous work (118–121). However, our analysis was performed at the country level, rather than at the regional level, because of lack of adequate representative regional studies and the absence of surveillance programmes.…”

Section: Discussionsupporting

confidence: 94%

Trends and projections of hepatitis C virus epidemiology in Latin America

Kershenobich¹,

Razavi²,

Sánchez-Ávila³

et al. 2011

Liver International

132

View full text Add to dashboard Cite

Background and aim: The purpose of the present investigation is to provide an analysis of previous works on the epidemiology of the hepatitis C virus (HCV) infection from six countries throughout Latin America, to forecast the future HCV prevalence trends in Argentina, Brazil, Mexico and Puerto Rico, and to outline deficiencies in available data, highlighting the need for further research. Methods: Data references were identified through indexed journals and non-indexed sources. Overall, 1080 articles were reviewed and 150 were selected based on their relevance to this work. When multiple data sources were available for a key assumption, a systematic process using multi-objective decision analysis (MODA) was used to select the most appropriate sources. When data were missing, analogues were used. Data from other countries with similar risk factors and/or population compositions were used as a proxy to help predict the future trends in prevalence. Results: The review indicates that the dominant genotype is type 1. HCV prevalence in the analysed countries ranges from 1 to 2.3%. The Latin American countries have been very proactive in screening their blood supplies, thus minimizing the risk of transmission through transfusion. This suggests that other risk factors are set to play a major role in continued new infections. The number of diagnosed and treated patients is low, thereby increasing the burden of complications such as liver cirrhosis or hepatocellular carcinoma. The HCV prevalence, according to our modelling is steady or increasing and the number of infected individuals will increase. Conclusions: The results herein reported should provide a foundation for informed planning efforts to tackle hepatitis.

show abstract

Section: Discussionsupporting

confidence: 94%

Trends and projections of hepatitis C virus epidemiology in Latin America

Kershenobich¹,

Razavi²,

Sánchez-Ávila³

et al. 2011

Liver International

132

View full text Add to dashboard Cite

show abstract

“…1–3 Prevalence of hepatitis B virus (HBV) is estimated at 2–4% in the general population of the Caribbean, 4 and hepatitis C virus (HCV) prevalence is approximately 1.2% in the greater LAC region. 5 Historically, the HIV epidemic in the Dominican Republic (DR) was considered generalised, but the country has transitioned to a more concentrated epidemic that disproportionately affects GMT, 6 who contribute one-third of new infections. 7 The Eastern region of the country reports a higher than average prevalence of HIV (5%), syphilis (10%) and HBV (4.3%) in GMT persons.…”

Section: Introductionmentioning

confidence: 99%

Risk behaviours and prevalence of sexually transmitted infections and HIV in a group of Dominican gay men, other men who have sex with men and transgender women

et al. 2015

View full text Add to dashboard Cite

ObjectivesThe objectives of this study were to estimate the point prevalence of sexually transmitted infection (STI) and to investigate the sexual practices and behaviours associated with STIs in a group of gay men, other men who have sex with men and transgender women (GMT) in the province of La Romana, Dominican Republic.DesignA cross-sectional study of a convenience sample of GMT persons.SettingThe study was conducted in the province of La Romana, Dominican Republic, in June–July 2013.ParticipantsOut of 117 GMT persons screened, a total of 100 completed the study. Participants had to be at least 18 years of age, reside in La Romana and have had sex with another man in the preceding 12 months. All participants were interviewed and tested for STI.Primary outcome measureThe main outcome of interest was the detection of any STI (HIV, herpes simplex virus type 2 (HSV-2), syphilis, hepatitis B or C) by serology.ResultsAmong 100 participants, the median age was 22 years (range 18–65). One-third had consumed illicit drugs the preceding year and only 43% consistently used condoms. Prevalence was 38% for HSV-2, 5% for HIV and 13% for syphilis. There were no cases of hepatitis B or C. Factors associated with the odds of a STI were age >22 years (OR=11.1, 95% CI 3.6 to 34.5), receptive anal intercourse (OR=4.2, 95% CI 1.3 to 13.6) and having ≥2 male sexual partners during the preceding month (OR=4, 95% CI 1.3 to 12.5).ConclusionsIn this group of GMT persons, seroprevalence of STI was high, and a number of risk behaviours were associated with STI. These preliminary data will help inform policy and programmes to prevent HIV/STI in GMT persons in the region.

show abstract

“…Robust epidemiological data in Latin America is missing. In Argentina, HCV prevalence is reported to be around 2% 82. However, small samples of specific populations show higher prevalence ranging from 2% to 7%.…”

Section: Discussionmentioning

confidence: 99%

“…In Argentina, HCV prevalence is reported to be around 2%. 82 However, small samples of specific populations show higher prevalence ranging from 2% to 7%. In intravenous drug users, sexual workers, and patients on hemodialysis, prevalence is between 5% to 50%.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis C in Argentina: epidemiology and treatment

Gaite

Marciano

Galdame

et al. 2014

HMER

View full text Add to dashboard Cite

Hepatitis C is the leading cause of chronic hepatitis, cirrhosis, and liver cancer in Argentina, where from 1.5% to 2.5% of adults are infected. Most of the infections were acquired 30–50 years ago. It is estimated that more than half of infected individuals are not aware of their infection. Even though the prevalence in blood donors has decreased to 0.45% at present, many high-prevalence populations still exist, where the reported prevalence ranges from 2.2% to 7.1%. Therapy is recommended for patients with fibrosis, in order to prevent disease progression, hepatic decompensation, and hepatocellular carcinoma. Great advances were achieved in the treatment of genotype 1 infection since the development and release of boceprevir and telaprevir. When either of these protease inhibitors is associated with peginterferon plus ribavirin, the sustained virological response (SVR) rate improves from 40%–50% to 67%–75%. For genotype 2 and 3 infection, treatment with peginterferon plus ribavirin is still the standard of care, with SVR rates of 70%–90%. There are significant new antivirals in development, and some of them are close to being released. These drugs will most likely be the future standard of care for all genotypes, and will be incorporated in better-tolerated and highly effective all-oral regimes. The impact that these new therapies might have in health-related economics is unpredictable, especially in developing countries. Each country must carefully evaluate the local situation in order to implement proper screening and treatment programs. Difficult-to-treat patients, such as those with decompensated cirrhosis, patients in hemodialysis, and those with other significant comorbidities, might not be able to receive these new therapeutic approaches and their management will remain challenging.

show abstract

Epidemiology of HCV infection in Latin America

Cited by 22 publications

References 16 publications

Trends and projections of hepatitis C virus epidemiology in Latin America

Trends and projections of hepatitis C virus epidemiology in Latin America

Risk behaviours and prevalence of sexually transmitted infections and HIV in a group of Dominican gay men, other men who have sex with men and transgender women

Hepatitis C in Argentina: epidemiology and treatment

Contact Info

Product

Resources

About