Epidemiology of Group B Streptococcus in developing countries

Johri, Atul Kumar; Lata, Hem; Yadav, P. S.; Dua, Meenakshi; Yang, Yonghong; Xu, Xiao-Ning; Homma, Akira; Barocchi, Michèle A.; Bottomley, Matthew J.; Saul, Allan; Klugman, Keith P.; Black, Steven

doi:10.1016/j.vaccine.2013.05.094

Cited by 43 publications

(45 citation statements)

References 25 publications

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“…In this study, we found that neonatal GBS infections were most commonly caused by serotypes III and Ia, and these findings concur with a previous report from the US [12]. However, our data differ from the results of a previous study comprising 1,500 pregnant Chinese women that was performed in the 1990s, wherein the reported Page 11 of 20 A c c e p t e d M a n u s c r i p t 11 serotype distribution was serotype II (36%)III( 26%) and Ia (18%), and neonates born from this cohort were colonized with a serotype distribution of Ia (13.5%), II( 9.5%), III(11.5%), and NT(57%) [13][14][15][16].…”

Section: Discussionsupporting

confidence: 93%

Serotype distribution, antimicrobial resistance, and molecular characterization of invasive group B Streptococcus isolates recovered from Chinese neonates

Wang

Tong

et al. 2015

International Journal of Infectious Diseases

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Section: Discussionsupporting

confidence: 93%

Serotype distribution, antimicrobial resistance, and molecular characterization of invasive group B Streptococcus isolates recovered from Chinese neonates

Wang

Tong

et al. 2015

International Journal of Infectious Diseases

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“…3,10,11 Such characterization is still at a very preliminary stage in most of the developing countries. 12 GBS serotyping is conventionally performed by the latex agglutination method, with a high rate of untypable strains or erroneous classifications. 3,11,13,14 In this context, the use of more sensitive and specific methods of GBS identification, such as molecular approaches based on the amplification of the nucleotide sequences of genes responsible for the expression of GBS capsular components, allow the recognition of strains not detected by conventional methods.…”

Section: ■ Resultsmentioning

confidence: 99%

Molecular Characterization of Group B Streptococcus Serotypes By Multiplex Polymerase Chain Reaction

Andrade¹,

Russo²,

Gouveia³

et al. 2017

Medical Express

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OBJECTIVE: Group B Streptococcus (GBS) serotypes (Ia, Ib and II to IX) are classified based on variations in their capsular polysaccharide; their prevalence differs between different geographic areas. We examined the prevalence of all GBS serotypes in rectal and vaginal swab samples obtained from 363 pregnant women followed at a Brazilian referral center (Hospital da Mulher Professor Doutor José Aristodemo Pinotti); bacterial susceptibility to antibiotics was further determined. METHOD: Prevalence of positive GBS was evaluated by latex agglutination and by multiplex PCR analysis; bacterial susceptibility to antibiotics, such as clindamycin, erythromycin, levofloxacin, linezolid, penicillin and tetracycline was determined by the disk diffusion method. RESULTS: (a) standard GBS culture and the multiplex PCR analysis tested positive for 83 swabs, collected from 72 women (prevalence of GBS colonization: 72/363; 20%); the most prevalent Serotype was Ia (n=43/83; 52%), followed by serotype V (n=14/83; 17%); according to anatomical origin, serotype Ia accounted for 27/59 (46%) and 16/24 (67%) of the vaginal and rectal samples, respectively; PCR also identified serotypes Ib, II, III and VI. Serotype VI is rarely described and had not been previously reported in Brazil or in Latin America. (b) The latex agglutination test only identified 44 positive samples, all of which were serotyped: 34 of these samples (77%) had serotypes matching those identified by multiplex PCR. (c) Only one sample (serotype Ia) showed resistance to erythromycin and clindamycin. CONCLUSION: Regional studies on GBS serotypes prevalence are essential to guide immunoprophylactic interventions (vaccines) and the implementation of adequate antibiotic prophylaxis or treatment. In this study, the incidence of the serotype VI, a new and rare serotype of GBS was described for the first time in a Brazilian population.

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“…Es por esto, que además de un buen tamizaje, se requieren métodos profilácticos costo efectivos y seguros para la gestante y su hijo, que garanticen el control de la colonización por SGB y consecuentemente lleven a una disminución de la morbimortalidad por secundaria a infecciones por este microorganismo. (52,53).…”

Section: Conclusionesunclassified

Prevención de la infección por Streptococcus del grupo B en gestantes

Sánchez

Arango

Díaz

et al. 2017

MedUNAB

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ResumenIntroducción: La infección neonatal por Streptococcus del Grupo B en mujeres gestantes es un problema creciente a nivel mundial y tiene múltiples consecuencias para el recién nacido, su prevención impacta directamente la morbimortalidad neonatal. Objetivo: Brindar al lector información relevante sobre la importancia clínica, nuevos métodos de tamizaje y formas de prevención de la infección por Streptococcus del Grupo B en gestantes, que será de utilidad para evitar complicaciones del binomio materno-fetal. Metodología: En esta revisión de la literatura, se estudiaron 53 artículos, abordando evidencia tanto en el ámbito local e internacional, utilizando las bases de datos PubMed, ScienceDirect y Google Scholar, dentro los criterios de búsqueda se tuvo en cuenta el año de publicación, incluyendo artículos que fueron publicados a partir del año 2011. Resultados: La comunidad internacional ha desarrollado guías y planes de prevención; en la actualidad, para una profilaxis y prevención adecuada se proponen diversos métodos, partiendo del tamizaje para las maternas, uso de antibióticos durante el embarazo y parto, además del desarrollo de vacunas maternas para prevenir infecciones. Conclusiones: La colonización por Streptococcus del Grupo B en gestantes y el riesgo que conlleva para el recién nacido y su madre, exige una constante actualización en técnicas de tamizaje, prevención y manejo. Numerosos avances en estos campos vienen llevándose a cabo en los últimos años y su fortalecimiento y desarrollo será clave para impactar positivamente la morbi-mortalidad materno-fetal. Abstract Introduction:The neonatal infection by Group B Streptococcus in pregnant women is a growing problem worldwide and has multiple consequences for the newborn, so its prevention directly impacts neonatal morbimortality. Objective: To provide the reader with relevant information about the clinical importance, new screening methods and ways to prevent Group B Streptococcus infection in pregnant women which will be useful to avoid complications in the pairing of maternal-fetal. Methodology: In this review of literature, 53 articles were studied addressing local and international evidence by using PubMed, ScienceDirect and Google Scholar databases; within the search criteria the year of publication was taken into account to do so, thus articles published from 2011 were included. Results: The international community has developed guidelines and prevention plans for this infection. Currently, for an adequate prophylaxis and prevention, various methods are proposed such as the screening for expectant mothers, the use of antibiotics during pregnancy and childbirth, and the development of maternal immunization to prevent infections as well. Conclusions: The colonization by Group B Streptococcus in pregnant women and the risk that this entails to the newborn and his/her mother requires constant updating in techniques for screening, prevention and management of it. Numerous advances in these fields of study have been carried out in recent years, ...

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Epidemiology of Group B Streptococcus in developing countries

Cited by 43 publications

References 25 publications

Serotype distribution, antimicrobial resistance, and molecular characterization of invasive group B Streptococcus isolates recovered from Chinese neonates

Serotype distribution, antimicrobial resistance, and molecular characterization of invasive group B Streptococcus isolates recovered from Chinese neonates

Molecular Characterization of Group B Streptococcus Serotypes By Multiplex Polymerase Chain Reaction

Prevención de la infección por Streptococcus del grupo B en gestantes

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