Epidemiology of Borna disease virus

Staeheli, Peter; Sauder, Christian; Hausmann, Jürgen; Ehrensperger, F; Schwemmle, Martin

doi:10.1099/0022-1317-81-9-2123

Cited by 206 publications

(210 citation statements)

References 92 publications

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“…The presence of BDV-RNA and proteins in peripheral blood mononuclear cells (PBMC) suggests possible transmission by blood. However, direct transmission of BDV from horses to horses or sheep to sheep has never been shown [62]. One should note that vertical transmission has been reported in horses [16,27].…”

Section: Transmissionmentioning

confidence: 99%

“…The experimental disease is possible for almost all of these species, including primates. Moreover, in the last ten years, specific markers for BDV infection have been detected in humans, in particular psychiatric patients, but the zoonotic aspect of the disease is still highly controversial [48,60,62].…”

Section: Host Range and Geographic Distributionmentioning

confidence: 99%

“…We still have much to learn about the route of transmission [54,61,62]. BDV is probably shed in nasal, salivary and 132 G. Dauphin et al conjunctival secretions since BDV-RNA has been detected in these secretions [31,50].…”

Section: Transmissionmentioning

confidence: 99%

“…Moreover, genome mutations identified in BDV strains isolated from horses, sheep and other domestic animals are not specific to animal species. This fact suggests a common viral source [48,62]. The natural source of infection is still unknown, but rodents are a potential reservoir and vector, even though their role in the Borna epidemiology has not yet been demonstrated.…”

Section: Transmissionmentioning

confidence: 99%

“…The viral aetiology was described at the beginning of the 20th century [68]. Borna disease was then known as a nonpurulent meningoencephalomyelitis, often fatal in horses and sheep bred in the endemic region: Germany and in the upper Rhine valley between Switzerland, Austria and the Principality of Liechtenstein [62,67]. The Borna disease virus (BDV) has now been isolated in several other countries and in many warmblooded animal species, including humans.…”

Section: Introductionmentioning

confidence: 99%

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Borna disease: current knowledge and virus detection in France

Dauphin¹,

Legay

Pitel

et al. 2002

Vet. Res.

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-For over two centuries, Borna disease (BD) has been described as a sporadically occurring infectious meningoencephalomyelitis affecting horses and sheep in Central Europe. Over the last decade, the BD epidemiology has been discussed. Firstly, its geographical distribution seems larger than what was previously thought. Secondly, the disease can affect a large number of warm-blooded animal species, including humans. The aetiological agent is the Borna disease virus (BDV), an enveloped, nonsegmented negative-stranded RNA virus classified in the new virus family Bornaviridae (Mononegavirales order). It can induce severe clinical signs of encephalitis with striking behavioural disturbances and may cause death. BDV genome has recently been detected in France in the blood and brain of several animal species (horses, bovines, foxes). meningoencephalomyelitis / Borna disease virus / epidemiology / diagnosisRésumé -La maladie de Borna : connaissances actuelles et détection du virus en France. La maladie de Borna est connue depuis plus de deux siècles en Europe centrale comme une méningoencé-phalomyélite d'origine infectieuse affectant les chevaux et les moutons. Depuis ces dix dernières années, l'épidémiologie de la maladie a été révisée puisque la répartition géographique de la maladie de Borna s'avère plus large que rapportée jusqu'alors. En outre, elle peut affecter un grand nombre d'espèces animales à sang chaud, y compris l'homme. L'agent étiologique est le BDV (virus de la maladie de Borna), virus enveloppé, à ARN simple brin, non segmenté et de polarité négative, récem-ment classifié dans la nouvelle famille des Bornaviridae, (ordre des Mononegavirales). Le BDV peut induire des signes cliniques sévères d'encéphalite virale avec des troubles comportementaux importants et il peut entraîner la mort de l'animal. Récemment, le génome du BDV a été mis en évidence en France dans le sang et le cerveau de plusieurs espèces animales (chevaux, bovins, renards). méningoencéphalomyélite / virus de la maladie de Borna / épidémiologie / diagnostic 127

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Section: Transmissionmentioning

confidence: 99%

Section: Host Range and Geographic Distributionmentioning

confidence: 99%