Negative-Strand RNA Virus Replication

Elliott, Richard M.

doi:10.1002/9780470688618.taw0214

Cited by 1 publication

(1 citation statement)

References 31 publications

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“…In order for this genome to be replicated, it has to be first converted into a positive-sense strand that can serve as a template for the production of viral RNA. The viral L protein cannot initiate this transcription process de novo, and therefore requires a primer (51). Mature cellular messenger RNAs (mRNAs) have a 5' methylated cap and a 3' poly (A) tail.…”

Section: Modulation Of the Host Mrna Degradation Pathways For Cap Snamentioning

confidence: 99%

How hantaviruses modulate cellular pathways for efficient replication

Hussein

Mir²

2013

Front Biosci

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Hantaviruses are zoonotic category-A pathogens that cause highly fatal diseases in humans. The hantaviral genome encodes three viral proteins: RNA-dependent RNA polymerase (RdRp or L protein), nucleocapsid protein (N), and a glycoprotein precursor (GPC), which is post-translationally cleaved into two surface glycoproteins Gn and Gc. The cytoplasmic tail of Gn interferes with interferon signaling pathways. N is a multifunctional molecule that was shown to be involved in the transcription and translation of viral proteins. N binds to the host mRNA caps and protects the degradation of mRNA 5' termini, which are later snatched and used as primers by the viral RdRp during transcription initiation. N also seems to lure the host translation machinery for the preferential translation of viral transcripts. Moreover, N was shown to delay the induction of cellular apoptosis and facilitate the transport and localization of viral ribonucleoproteins (RNPs) by exploiting the cellular cytoskeleton and SUMOlyation machinery. Therefore, with their limited protein coding capacity, hantaviruses have evolved several strategies to modulate cellular pathways for their efficient replication.

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Section: Modulation Of the Host Mrna Degradation Pathways For Cap Snamentioning

confidence: 99%