Borna disease: current knowledge and virus detection in France

Dauphin, Gwenae͏̈lle; Legay, Vincent; Pitel, Pierre‐Hugues; Zientara, Stéphan

doi:10.1051/vetres:2002002

Cited by 17 publications

(7 citation statements)

References 61 publications

(91 reference statements)

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“…The virus is mainly found as a causative factor of borna disease in horses, birds, rodents, and primates (34). BDV may also play a role in human neurological and psychiatric conditions.…”

Section: Borna Disease Virus (Bdv)mentioning

confidence: 99%

Infectobesity: a New Area for Microbiological and Virological Research

Nam

2011

J Bacteriol Virol

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Obesity is connected with numerous diseases, such as type 2 diabetes, atherosclerosis, cancer, and nervous system dysfunctions. Obesity is affected by genetic, environmental, and cultural factors. However, numerous studies indicate that several pathogens might cause obesity. This review discusses recent data and the characteristics of pathogens that are implicated in obesity. In particular, human adenovirus 36 (Ad36) is the most clearly implicated virus in human obesity. It was recently shown that obese groups from the USA, Korea, and Italy have a higher prevalence of serum antibodies against Ad36. The mechanisms of Ad36-induced obesity remain unclear. However, glucose uptake and inflammation are possible mechanisms of Ad36-induced obesity. Overall, this new understanding of causes of obesity has developed into the concept of 'infectobesity' and the possibility of developing a 'vaccine' or 'therapeutic agents' for obesity. million women were considered to be obese (Fig. 1A and 1B). Thus, more than one in ten of the world's adult population was obese. Close to 35 million overweight children live in developing countries and eight million in developed countries, which means that overweight children are a problem in all countries. Overweight and obesity also account for 44% of the diabetes burden, 23% of the ischemic heart disease burden, and between 7% and 41% of certain cancer burdens. Recently, the obesity rate among Koreans has increased drastically (Fig. 1C). In 1995, 11.7% of women and 18% of men were considered to be obese.However, 29.4% of women and 32.6% of men were considered obese in 2001 and the obese ratio recently increased further. There was also a noticeable increase in the ratio of obese children and adolescents (1).The costs of treating obesity and obesity-related metabolic disease account for 40% of total health expenditure in the USA and this recent trend is dramatically increasing (2).The social and economic cost of obesity therapy is more than 1 billion dollar and diabetes treatments account for 19.2% of the national medical insurance premium in Korea (3). Thus, obesity-related diseases are a severe loss to the national economy.There are many causes for obesity, such as genetics, medical problems, or psychiatric illness. Simply put, obesity is a result of an energy imbalance, where the energy intake is greater than energy expenditure (4) and excess energy accumulates in adipose tissue. Increasing rates of obesity at the societal level are attributed to easy access to a palatable diet, increased dependence on cars, and mechanized manufacturing. However, the recent increase in obesity might be

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“…The virus is mainly found as a causative factor of borna disease in horses, birds, rodents, and primates (34). BDV may also play a role in human neurological and psychiatric conditions.…”

Section: Borna Disease Virus (Bdv)mentioning

confidence: 99%

Infectobesity: a New Area for Microbiological and Virological Research

Nam

2011

J Bacteriol Virol

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“…The clinical manifestations in Lewis rats infected with BDV range from obesity and fertility problems to behavioural, neurological changes and even paralysis. 32,36 Herden et al 37 compared the alterations in the brains of Lewis rats experimentally infected with two BDV strains. When the animals where infected with the isolate BDV-biphasic (BDV-bi) they developed a persistent infection of the CNS with a characteristic biphasic course of the disease.…”

Section: Rous-associated Virus Typementioning

confidence: 99%

Could a virus contribute to weight gain?

Vasilakopoulou

Roux

2007

Int J Obes

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“…Experimentally, BDV can also be transmitted to birds, rodents, and monkeys, and it is likely that the host range includes all warm-blooded animals and birds [52,58,60,61]. The exact geographic distribution of the virus is uncertain, but serologic evidence has documented infection in Europe, the United States, and Asia [62][63][64][65][66][67][68][69][70].…”

Section: Epizootiologymentioning

confidence: 99%