Epidemiology of Allergic Rhinitis Caused by Grass Pollen or House-dust Mites in Spain

Valero, Antonio; Justicia, José L; Antón, E.; Dordal, M T; Fernández-Parra, B; Lluch, M; Montoro, J; Navarro, Ana

doi:10.2500/ajra.2011.25.3599

Cited by 23 publications

(19 citation statements)

References 26 publications

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“…32, No. 4,2015 with persistent allergic rhinitis, but our study revealed that this risk is correlated with allergic rhinitis duration and sensitization to house dust mites, similar to other studies (3,28,29). However, there is no correlation between baseline cytokine levels and the risk of asthma after 1.5 years.…”

Section: Discussionsupporting

confidence: 75%

In Vivo Anti-Inflammatory Effect of H1 Antihistamines in Allergic Rhinitis: A Randomized Clinical Trial

et al. 2015

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Background: Allergic rhinitis is characterized by a chronic inflammation of nasal mucosa and represents a risk factor for asthma occurrence. H1 antihistamines reduce the symptoms of rhinitis, but some compounds may have anti-inflammatory properties. Aims: We evaluated the plasma level of some cytokines in patients with persistent allergic rhinitis (PAR) and their evolution after a 4-week treatment with H1 antihistamines, as well as the risk of asthma after 1.5 years. Study Design: Randomized clinical trial. Methods: Eighty-five patients with PAR and 30 healthy volunteers were included in the study. The patients with PAR were randomly divided into 2 groups: 41 patients treated with 5 mg/day desloratadine and 44 patients under 5 mg/day levocetirizine for 4 weeks. The clinical and biological evaluations were performed before and after treatment and included rhinitis symptoms and total symptoms score, type of sensitization, and plasmatic levels of total IgE, IL-1β, IL-6, IL-8 and TNF-α. Results: IL-8 and TNF-α were significantly increased in patients with PAR compared to healthy volunteers (5.85 vs 3.12, p<0.001 and 2.32 vs 1.06, p<0.001, respectively). Both H1 antihistamines reduce all symptoms of allergic rhinitis, including nasal congestion and the plasmatic level of IL-1β, IL-6, IL-8 and TNF-α, after 4 weeks of treatment. The reduction of cytokine levels was not influenced by patients' age, sex, duration or severity of rhinitis, or type of sensitization. Levocetirizine has a superior effect compared to desloratadine in reducing the rhinitis symptoms and cytokines' level. Twenty eight (32.9%) of the patients presented asthma symptoms after 1.5 years. The occurrence of asthma was influenced by house dust sensitization (OR-14.6; CI 95% 1.8-116.3; p=0.01), but baseline values of cytokines were not predictive factors for its appearance. Conclusion: Levocetirizine and desloratadine as a prolonged therapy reduce plasmatic levels of some proinflammatory cytokines in patients with PAR. Levocetirizine has a better effect on decreasing the symptoms and plasmatic levels of IL-1β and IL-8. (ClinicalTrials. gov Identifier: NCT02507635) Founding: POSDRU and University of Medicine and Pharmacy, Iuliu Haţieganu, Cluj Napoca.

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Section: Discussionsupporting

confidence: 75%

In Vivo Anti-Inflammatory Effect of H1 Antihistamines in Allergic Rhinitis: A Randomized Clinical Trial

et al. 2015

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“…To our knowledge, no other pediatric study has examined similar North‐South gradients at country level in Europe and linked to markers of disease severity or comorbidities. Geographic differences of sensitization patterns in patients with respiratory allergies have been reported in Spain or France , but they focused on coast vs. continental areas rather than a North‐South gradient. Given its geographic characteristic (a country elongated from North to South), Italy can reproduce better than other countries the North‐South gradients typically observed, on a wider scale, at European level.…”

Section: Discussionmentioning

confidence: 99%

Pollen‐induced allergic rhinitis in 1360 Italian children: Comorbidities and determinants of severity

Dondi

Tripodi

Panetta

et al. 2013

Pediatric Allergy Immunology

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“…18 The discrepancy can perhaps be explained by the fact that 73% of the patients were recruited between January and May when the period of greatest severity of symptoms of allergic rhinitis due to HDM, including nasal congestion, is between October and December. 19 Pharmacologic symptomatic treatment was indicated in almost all patients included in the study and agents were used in combination. Up to 92% of the patients were prescribed oral second-generation antihistamines even though there is still some debate concerning the efficacy of these agents.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and Treatment of Allergic Rhinitis due to House-Dust Mites in Spain

Valero

Justicia

Vidal

et al. 2012

Am J Rhinol�Allergy

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When patients with HDM-induced allergic rhinitis are referred to an allergy specialist in Spain, they have moderate-to-severe persistent disease and are generally not achieving good control with symptomatic treatment. Allergen immunotherapy is prescribed in approximately one-half of patients. In this representative sample of Spanish allergy specialists, the level of adherence to clinical guidelines in these patients is encouraging.

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Epidemiology of Allergic Rhinitis Caused by Grass Pollen or House-dust Mites in Spain

Cited by 23 publications

References 26 publications

In Vivo Anti-Inflammatory Effect of H1 Antihistamines in Allergic Rhinitis: A Randomized Clinical Trial

In Vivo Anti-Inflammatory Effect of H1 Antihistamines in Allergic Rhinitis: A Randomized Clinical Trial

Pollen‐induced allergic rhinitis in 1360 Italian children: Comorbidities and determinants of severity

Diagnosis and Treatment of Allergic Rhinitis due to House-Dust Mites in Spain

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