Epidemiology and outcome of invasive pneumococcal disease among adults in Belgium, 2009–2011

Abstract

NoteVariation assessment report as adopted by the CHMP with all information of a commercially confidential nature deleted.

Anti-Pneumococcal Capsular Polysaccharide Antibody Response and CD5 B Lymphocyte Subsets

“…To These serotypes were selected because they are immunogenic (20) and have been prevalent in Belgium over the last 15 years (21,22). SCID mice reconstituted with CD19 ϩ CD5 Ϫ B cells produced significantly higher levels of IgG antibodies than did SCID mice reconstituted with CD19 ϩ CD5 ϩ B cells (Fig.…”

Pneumococcal serotype distribution: A snapshot of recent data in pediatric and adult populations around the world

“…PCV serotypes were responsible for >60% of total serotypes in IPD cases in few studies among adults aged 65 y and older 6,58 and 15-59 y. 6,57 Overall, serotypes 1, 4, 14 and 19A were among the most prevalent PCV serotypes among adults with IPD, while serotype 3 is the most common PCV serotype among adult IPD cases in North America. While the current picture suggests that the availability of PCVs may have had a great effect in targeting PCV-specific serotypes among adult IPD cases, the introduction of PCV7 previously led to an overall reduction in the incidence of all-type IPD ranging from 80% in the US to 30-40% in Europe among children aged less than 5 y.…”

“…30 Conjugate vaccine serotypes causing IPD were highly prevalent (> 60% of serotypes) in 2 studies. 6,57 Prevalence of serotypes uniquely covered by PPV23 was reported in 4 studies 6,9,24,57 2 of which reported 12F to be most prevalent. Other prevalent serotypes of note were 8 (4 studies; 4.7%), 6,9,24,57 22F (4 studies; 4.1%) 6,9,24,57 and 9N (3 studies; 3.5%).…”

“…There were 9 studies reporting serotype distribution data among adults aged 65 y and older with IPD 5,6,18,24,[55][56][57][58][59] and another 3 with similar data on non-IPD conditions (Table 2). [60][61][62] Conjugate vaccine serotypes (i.e., serotypes included in PCV13) causing IPD among older adults were highly prevalent (> 60% of serotypes) in only 2 studies, one Polish 6 and one Spanish.…”

“…6,24,57 Collective prevalence of serotypes not covered by any pneumococcal vaccines ranged from 2.8% to 13.0%.…”