Epidemiology and burden of osteoarthritis

Litwic, Anna; Edwards, Mark H.; Dennison, Elaine; Cooper, Cyrus

doi:10.1093/bmb/lds038

Cited by 943 publications

(766 citation statements)

References 46 publications

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“…Hip and knee OA causes the greatest burden to the population in terms of pain, stiffness and disability, thereby leading to the need for prosthetic joint replacement for the most severe cases (8). The disease may have various personal, social and economic consequences for patients, their environment and society: reduced productivity or premature exit from the workplace, autonomy loss, need for help, as well as increased healthcare use and sometimes institutionalization (9).…”

Section: Introductionmentioning

confidence: 99%

Economic impact of lower-limb osteoarthritis worldwide: a systematic review of cost-of-illness studies

Salmon

Rat

Sellam

et al. 2016

Osteoarthritis and Cartilage

158

111

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International audienceObjectiveAn overview of the economic consequences – overall costs as well as cost breakdown (direct and indirect) – of hip and knee osteoarthritis (OA) worldwide.MethodsA systematic literature search of EMBASE, MEDLINE, Scopus and Cochrane databases for articles was performed independently by two rheumatologists who used the same predefined eligible criteria. Papers without abstracts and in languages other than English or French were excluded. Extracted costs were converted to an annual cost and to 2013 euros (€) by using the Consumer Price Index of the relevant countries and the 2013 Purchasing Power Parities between these countries and the European Union average.ResultsA total of 45 abstracts were selected, and 32 articles were considered for the review. The studied populations were heterogeneous: administrative, hospital and national health survey data. Annual total costs per patient ranged from 0.7 to 12 k€, direct costs per patient from 0.5 to 10.9 k€ and indirect costs per patient from 0.2 to 12.3 k€. The weighted average annual costs per patient living with knee and hip OA were 11.1, 9.5 and 4.4 k€ for total, direct and indirect costs, respectively.ConclusionsThis review highlights the heterogeneity of studies and lack of methodologic consensus to obtain reliable cost-of-illness estimates for lower-limb OA. However, costs induced by the disease seem substantial and deserve to be more extensively explored

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Section: Introductionmentioning

confidence: 99%

Economic impact of lower-limb osteoarthritis worldwide: a systematic review of cost-of-illness studies

Salmon

Rat

Sellam

et al. 2016

Osteoarthritis and Cartilage

158

111

View full text Add to dashboard Cite

show abstract

“…The quality of life of these population is poor in the end-stage of OA due to joint destruction (3). Currently, joint replacement is considered as an effective treatment for end-stage OA; however, high socioeconomic cost, poor functional outcomes and the limited lifespan of prostheses influence its application and efficacy (4,5). Thus, it is imperative to search for new and effective intervention and therapy for OA.…”

Section: Introductionmentioning

confidence: 99%

miR-4262 regulates chondrocyte viability, apoptosis, autophagy by targeting SIRT1 and activating PI3K/AKT/mTOR signaling pathway in rats with osteoarthritis

Sun

Li²,

Wei³

2017

Exp Ther Med

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Abstract. The present study aimed to investigate the effect and underlying mechanism of microRNA (miR)-4262 in the development of osteoarthritis (OA) in rats. Primary chondrocytes were separated from Sprague-Dawley rats and then treated with tumor necrosis factor-α (TNF-α). The level of miR-4262 was detected in TNF-α-treated chondrocytes, and then the miR-4262 or its target gene sirtuin type 1 (SIRT1) level was overexpressed, or knocked down. Furthermore, cell viability, cell apoptosis, cell autophagy and matrix synthesis, as well as the expressions of proteins associated with the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway were detected. miR-4262 was significantly overexpressed in TNF-α-treated chondrocytes compared with untreated cells (P<0.05). TNF-α treatment or miR-4262 overexpression significantly decreased cell viability, autophagy-related proteins levels and matrix synthesis-related proteins levels, as well as increased the apoptotic rate in chondrocytes (P<0.05). Overexpression of SIRT1 significantly increased cell viability, autophagy-related proteins levels and matrix synthesis-related proteins levels, as well as decreased the apoptotic rate in TNF-α-treated chondrocytes (P<0.05). In addition, the effects of miR-4262 on cell viability, cell apoptosis, cell autophagy and matrix synthesis were inhibited by SIRT1 (P<0.05). Furthermore, upregulated miR-4262 remarkably increased the expressions of phosphorylated (p)-PI3K, p-AKT and p-mTOR (P<0.05) in TNF-α treated chondrocytes. The present study revealed that the upregulation of miR-4262 may promote the occurrence and development of OA in rats by regulating cell viability, cell apoptosis, cell autophagy, and matrix synthesis. Furthermore, these roles of miR-4262 may be associated with PI3K/AKT/mTOR signaling pathway.

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“…The prevalence of osteoarthritis varies greatly depending on the definition used, age, sex and geographical area studied. 16,17 Difference in our study could be due to more patients in age group 21-50 years. MRI is an excellent tool for diagnosis of intraarticular tumors which in our study shows 4% incidence.…”

Section: Discussionmentioning

confidence: 57%

MRI detected prevalence of abnormalities in patients of knee pain

Mehta¹,

Agrahari²,

Agarwal³

et al. 2015

Int J Res Med Sci

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Epidemiology and burden of osteoarthritis

Abstract: Further research is required to fully understand how OA affects an individual physically and psychologically, and to determine their healthcare need.

Cited by 943 publications

References 46 publications

Economic impact of lower-limb osteoarthritis worldwide: a systematic review of cost-of-illness studies

Economic impact of lower-limb osteoarthritis worldwide: a systematic review of cost-of-illness studies

miR-4262 regulates chondrocyte viability, apoptosis, autophagy by targeting SIRT1 and activating PI3K/AKT/mTOR signaling pathway in rats with osteoarthritis

MRI detected prevalence of abnormalities in patients of knee pain

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